Dr Jolet Mimpen

My condolences. Sending you all much love and strength.

24.07.2025 18:23 — 👍 4    🔁 0    💬 0    📌 0

Exploring cellular changes in ruptured human quadriceps tendons at single‐cell resolution Abstract figure legend This study explores the cellular landscape of healthy and ruptured quadriceps tendons using single nucleus RNA sequencing. While a range of stromal and immune cell types and su...

Link to our paper "Exploring cellular changes in ruptured human quadriceps tendons at single-cell resolution":
physoc.onlinelibrary.wiley.com/doi/10.1113/...

21.07.2025 16:58 — 👍 1    🔁 0    💬 0    📌 0

Finally, a big thank you to Asst Prof @mvfranchi.bsky.social, Dr Christopher Fry, and Prof Michael Kjaer for writing this wonderful piece highlighting our work!

21.07.2025 16:55 — 👍 2    🔁 0    💬 1    📌 0

Cellxgene Data Portal Find, download, and visually explore curated and standardized single cell datasets.

This study was a big team effort as part of the @cziscience.bsky.social-funded "Tendon Seed Network" led by @sarahsnelling.bsky.social, Dr Mathew Baldwin, @adamcribbs.bsky.social & many others @ndorms.bsky.social.

All the data can be viewed & downloaded:
cellxgene.cziscience.com/collections/...

21.07.2025 16:55 — 👍 1    🔁 0    💬 1    📌 0

This Graphical abstract depicts healthy and acutely ruptured human quadriceps tendons. Using single nucleus RNA sequencing, the analysis shows that stromal cells change in ruptured quadriceps tendons, including increase of activated phenotype of fibroblasts, vascular endothelial cells, and macrophages, as well as increase in cell-cell interactions between fibroblasts and vascular endothelial cells.

The transcriptomics analysis of our paper "Exploring cellular changes in ruptured human quadriceps tendons at single-cell resolution" suggests that fibroblasts and endothelial cells are key orchestrators of the early injury response within ruptured quadriceps tendon.

21.07.2025 16:55 — 👍 2    🔁 0    💬 1    📌 0

Very excited to see this Translational Perspective by Asst Prof @mvfranchi.bsky.social, Dr Christopher Fry, and Prof Michael Kjaer discussing our recent transcriptomics study on the early injury response in human quadriceps tendons in @jphysiol.bsky.social.

21.07.2025 16:55 — 👍 7    🔁 2    💬 1    📌 0

Congratulations! 👏🏻

07.03.2025 23:52 — 👍 2    🔁 0    💬 0    📌 0

Happy New Year! Could you add me as well, please?

02.01.2025 20:15 — 👍 1    🔁 0    💬 0    📌 0

If you're interested in the extracellular matrix of soft tissues and the role ECM plays in osteoarthritis then this systematic review is for you!

boneandjoint.org.uk/Article/10.1...

03.12.2024 13:15 — 👍 10    🔁 5    💬 0    📌 0

Interested? Do take a look at Supplementary Tables i and ii!

These tables provide an overview of the data on ECM features by tissue type in humans (Table i) and animal models of OA (Table ii), including the direction of change in OA, measurement method, and references.

03.12.2024 11:36 — 👍 1    🔁 0    💬 0    📌 0

Defining the extracellular matrix in non-cartilage soft-tissues in osteoarthritis: a systematic review | Bone & Joint Defining the extracellular matrix in non-cartilage soft-tissues in osteoarthritis: a systematic review

It is great to finally share our systematic review on structural extracellular matrix components in soft tissues in osteoarthritis!

Congratulations to my co-authors Iwan Raza and @sarahsnelling.bsky.social.

boneandjoint.org.uk/Article/10.1...

03.12.2024 11:36 — 👍 6    🔁 1    💬 1    📌 1

Wonder what it is like to study at @ndorms.bsky.social at the University of Oxford? Here we share some of our experiences from working in an interdisciplinary team with the wonderful @sarahsnelling.bsky.social.

Please feel free to get in touch if you have any questions!

27.11.2024 11:44 — 👍 2    🔁 0    💬 0    📌 0