Kit(ryiel)

Nation Can't Believe It On Harvard's Side

I talk a lot about how damaging our current rampant use of concrete is to the environment and no one ever seems to know what I’m talking about but I’m SUPER glad to hear of this. Let’s make it the standard within a decade!

a silhouette of a person with the words "what is the dumbest thing i could say". a speech bubble emanates from the person with a bluesky "reply" button

i am releasing the schematics for my account

The era we were in of "it's not that deep, and it's cringe to care about things you like" has done considerable damage to the way we talk to each other, empathize, etc.

Talk about the things you care about. What's truly 'cringe' is people minimizing you and telling you it's not important. It is.

me reading national security secrets bc i've been accidentally added to a group chat

Republicans will pass laws saying that teachers are mandated to out their queer kids to their parents and you people will go on saying that teachers are all the most decent and selfless and underappreciated people in the world and would surely never actually obey the law making them do that shit

"despite" is one way to say "in violation of," I guess

Young Veronica

TATTOO DAY TATTO DAY TATTOO DAY

A poster for the economic blackout on February 28. It is a big red Jack rabbit on an aqua blue back ground. It says economic blackout in hand done black type. There are two black speech bubbles. One says “don’t buy stuff Friday February 28th. The other says we have power. Below it says No Amazon, Walmart, target, gas food, gas. Below that it says OK small business, use cash. Designed by Martha Rich.

I made this the other night while procrastinating, mainly because I thought all the posts about the blackout were boring. It feels like there is momentum bringing people together!

This is huge and monstrous. The nasal vaccines are our only hope of getting back to a world where you don't have to fear getting covid indoors. I would like to stop masking some day, and they're going to make it impossible.

IMPORTANT THINGS TO NOTE !! • KEEP IN MIND THESE ARE RESULTS THAT HAVE HELD UP APPROXIMATELY THREE YEARS showing that benefits demonstrated years ago have held up over time. That is ASTOUNDING. • Researchers say the results of a Phase I trial of an therapeutic cancer vaccine aimed at preventing kidney cancer show promise. • This new study found that ALL patients with ADVANCED stage kidney cancer had successful anti-cancer immune responses AND have remained CANCER-FREE approximately THREE years after treatment. • The study, demonstrates the potential of personalized vaccines to change the course of certain cancer types, but larger, longer trials are needed to confirm this approach. • Cancer vaccines developed with different molecular recipes are still in their early stages, before strong conclusions can be made. • While the findings are encouraging, the vaccine is still in early testing and will likely take years before it becomes widely available.

How personalized peptide cancer vaccines work Scientists identify neoantigens, abnormal proteins produced by cancer cells. They take a sample of the patient's mutated cancer cells. The neoantigens are used to create a vaccine tailored to the patient's tumor. The vaccine is administered, prompting the immune system to target the cancer cells with those proteins. The immune system's T-cells attack and destroy the tumor cells, shrinking the cancer.

ABSTRACT Personalized cancer vaccines (PCVs) can generate circulating immune responses against predicted neoantigens. However, whether such responses can target cancer driver mutations, lead to immune recognition of a patient's tumour and result in clinical activity are largely unknown. These questions are of particular interest for patients who have tumours with a low mutational burden. Here we conducted a phase l trial (ClinicalTrials.gov identifier NCTO2950766) to test a neoantigen-targeting PCV in patients with high-risk, fully resected clear cell renal cell carcinoma (RCC; stage Ill or IV) with or without ipilimumab administered adjacent to the vaccine. At a median follow-up of 40.2 months after surgery, none of the 9 participants enrolled in the study had a recurrence of RCC. No dose-limiting toxicities were observed. All patients generated T-cell immune responses against the PCV antigens, including to RCC driver mutations in VHL, PBRM1, BAP1, KDM5C and PIK. Following vaccination, there was a durable expansion of peripheral T-cell clones. Moreover, T-cell reactivity against autologous tumours was detected in seven out of nine patients. Our results demonstrate that neoantigen-targeting PCVs in high-risk RCC are highly immunogenic, capable of targeting key driver mutations and can induce antitumour immunity. These observations, in conjunction with the absence of recurrence in all nine vaccinated patients, highlights the promise of PCVs as effective adjuvant therapy in RCC.

This study involved a large and collaborative team across multiple institutions, with key leadership from co-senior authors Toni Choueiri, Derin Keskin, Patrick Ott, and Catherine Wu from DFCI. Research reported in this release was supported by the National Institutes of Health under award numbers 1R37CA279822-01 and P30CA016359. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The research was also funded by the Gateway for Cancer Research, U.S. Department of Defense, Louis Goodman and Alfred Gilman Yale Scholar Fund, Yale Cancer Center, Dana-Farber/ Harvard Cancer Center, Harvard Medical School, Trust Family Foundation, Michael Brigham, Pan Mass Challenge, Hinda L. and Arthur Marcus Foundation, The Loker Pinard Fund for Kidney Cancer Research at Dana-Farber Cancer Institute, and Conquer Cancer Foundation/Sontag Foundation.

The study has been published in Nature. YES, it is PEER-REVIEWED.
• www.nature.com/articles/s41...

IMPORTANT THINGS TO NOTE ‼️

THIS IS HUGE! A cancer vaccine developed by Yale University and DFCI shows MAJOR promise. Results of an early-phase trial reveal ALL patients with ADVANCED stage kidney cancer had successful anti-cancer immune responses AND have remained CANCER-FREE approximately THREE years after treatment. 🧪🧵⬇️

“Porn” is a public good.

“Porn” is the sign of a healthy, open society.

“Porn” is record of the diversity of sexual expression.

“Porn” brings people joy, access to parts of themselves that they may not have another way to express.

It’s worth defending on its own.

PUT YOUR MONEY WHERE YOUR MOUTH IS!
SPREAD THE WORD!
2/2

HIT EM WHERE IT HURTS
1/2

what IS severance?

#severance

Something that’s very clear is that Trump is old and checked out. He wants to play the role of president but has zero interest in doing the job and is happy to outsource the real work to Musk, Vought and a crew of feral zealots.

Absolutely

same hat meme but it is edited to say ‘same pronouns’

whenever I see a she/they here, I do a gay little wave like this

He’s not making up: news.bloomberglaw.com/banking-law/...

Is this really what y’all voted for? 🫤 💰

hello cis friends
this is what people mean by trans genocide

if a type of person does not officially exist, then any harm against them cannot be measured or reported

this headline change isn't even being caused by an executive order

it's simply the NYT editors deciding we don't deserve to exist

TURN HIS TV OFF

They really want to force young white women out of the workforce. And it is wild to watch conservative white women stump for their own subjugation. Because when they are not longer useful they will find out the cage isn't even gilded

My least favorite part about what I've begun to call the "popular artist paradox"

is that there's now enough culture here that if the remaining artists just bit the bullet, I think they'd drive a lot of culture here and away from rich, apartheid, nazi boys.

Artists have more pull than they think.

Two figures walk along a corridor lined with complex machinery. The worker says "Congratulations, sir! The most intelligent machine ever created is ready to change the world. Ten billion dollars well spent... What shall we ask it to do? " The billionaire replies "That's my business, not yours. Close the door on your way out." Now alone with the machine, the billionaire asteps closer and asks quietly "Can you Make people like me?" it says "No"

My latest cartoon for @newscientist.com

I love my new daughter