Matthew Blakeley

Counter-diffusion studies of human transthyretin: the growth of high-quality crystals for X-ray and neutron crystallography X-ray and neutron diffraction studies of human transthyretin crystallized using the non-convective counter-diffusion method provide important insights into crystallization quality relevant for the gro...

Link to the publication journals.iucr.org/j/issues/202...

Counter diffusion crystallization of human transthyretin: a pipeline toproduce high-quality crystals for neutron studies - PSB Human transthyretin (TTR), a thyroxine and retinol-binding protein transporter in the blood and cerebrospinal fluid, can become amyloidogenic with age or by single point mutations causing hereditary a...

PSB Scientific Highlights - Counter diffusion crystallization of human transthyretin: a pipeline toproduce high-quality crystals for neutron studies www.psb-grenoble.eu/2025/10/31/c...

The first neutron diffraction pattern using the new detector installed on the DALI instrument at ILL, and what a beautiful pattern it is! This has been a huge effort and great work by all involved - Un grand merci à Olivier, Benjamin, Lukas, Juliette et Théodore! @illneutrons.bsky.social

Neutrons are the best ... look at this histidine-galactose contact !! Our new neutron structure of lectin/gal is available as preprint in ChemRXiv chemrxiv.org/engage/chemr.... Thanks to @drmpblakeley.bsky.social @sebvidalchem.bsky.social and all colleagues for very fine collaboration

Thanks Stefano! 😀

Here is one of the #neutron quasi-Laue diffraction patterns collected from SHMT using the LADI-DALI beamline at Institut #Laue-Langevin

FEBS Press Room-temperature neutron crystallography revealed protonation states in pyridoxal-5′-phosphate (PLP)-dependent TthSHMT enzyme in the apo-form and in complex with glycine external aldimine (PLP–Gly) a....

febs.onlinelibrary.wiley.com/doi/10.1111/...

Current and future perspectives for structural biology at the Grenoble EPN campus: a comprehensive overview Details on the current status of the experimental techniques available at the ESRF–EBS and ILL research infrastructures are provided. Major contributions made by the EMBL, ESRF, ILL and IBS to the str...

Current and future perspectives for structural biology at the Grenoble EPN campus: a comprehensive overview journals.iucr.org/s/issues/202...