Keith Matthews

doi.org/10.7554/eLif...

A further great collaboration with @allshire-lab.bsky.social !

The Matthews Lab | Biology The Matthews Lab

We have a 3+ year post doc available in our lab to study trypanosome transmission and virulence. Combined wet lab and bioinformatics expertise preferred. Please apply via the HR link (elxw.fa.em3.oraclecloud.com/hcmUI/Candid...). Find out more about us in the link below.

Update: contract duration extended to 2029 (i.e. now a ~almost 4 year contract duration). Please apply by 6th June!

You know the answer….

Please consider applying for a post doc in our lab if you have bioinformatics and wet lab skills, and are interested in parasites!

elxw.fa.em3.oraclecloud.com/hcmUI/Candid...

Defining the chromatin-associated protein landscapes on Trypanosoma brucei repetitive elements using synthetic TALE proteins Kinetoplastids, such as Trypansoma brucei, are eukaryotes that likely separated from the main lineage at an exceptionally early point in evolution. Consequently, many aspects of kinetoplastid biology ...

Exploring the chromatin proteome of Trypanosoma brucei repetitive elements (telomeres, centromeres, 70bp repeats, 177bp repeats) using TALEs. Another great collaboration with @allshire-lab.bsky.social

www.biorxiv.org/cgi/content/...

We're based in the Ashworth Laboratories, King's Buildings, University of Edinburgh. Photo shows the main staircase in the entrance to the Ashworth, stone steps from the 1920s, decorated with a series of bright, colurful banners depicting the science that's tackled in the building.

I'm very pleased to have two lab positions open this week, to join our team looking at immune regulation in infection and co-infection. We're especially interested in tissue-based immunity, cytokine regulation and immune metabolism. Join us! Postdoc (3y) and research technician (12mo) posts open.

Not the Oscars, but super proud of daughter #1s video editing for the Glasgow fashion show

Trypanosoma brucei cattle infections contain cryptic transmission-adapted bloodstream forms at low parasitaemia Tsetse-transmitted Trypanosoma parasites infect a wide host range and cause Human African Trypanosomiasis and Animal African Trypanosomosis in sub-Saharan Africa. The primary hosts of Trypanosoma bruc...

We've previously looked at the developmental biology of trypanosome infections in mice, but parastaemias are unnaturally high in mice compared to cattle. Read what happens in cattle when blood parasitaemias are low and so quorum sensing may be limited...

www.biorxiv.org/content/10.1...

Really interesting day discussing impacts of climate change on vector borne diseases workshop today. Lots of great science and discussion about exciting projects to take forwards. @keithrmatthews.bsky.social #reecelab @roslininstitute.bsky.social @amypedersen.bsky.social

CABIOS EDITORIAL R.J. Beynon; CABIOS EDITORIAL, Bioinformatics, Volume 1, Issue 1, 1 January 1985, Pages 1, https://doi.org/10.1093/bioinformatics/1.1.1

Having played a small part in a manuscript to be published in the journal 'Bioinformatics' I was interested to read the inaugural article about the journal from founding editor Rob Beynon in 1985. Worth a read (I hope OA) to see how things move on.
academic.oup.com/bioinformati...

At the top right is one featuring the esteemed Derrick Robinson…doesn’t get better than that!

Amplifying affected voices: neglected tropical diseases | Free exhibition A powerful exhibition to mark World Neglected Tropical Disease Day.

As the world marks Neglected Tropical Diseases Day, researchers from @edinburgh-uni.bsky.social are collaborating with the #RoyalSocietyofEdinburgh and #UnitingtoCombatNeglectedTropicalDiseases to host a free, public exhibition 31 Jan - 4 Feb. Get tickets now!

www.eventbrite.co.uk/e/amplifying...

Breakfast with colleagues at a conference when you’ve just received mixed reviews on your latest paper

The Institute kindly provided us with a new board to display our papers. Only a selection, but each one of them brought back such strong memories of the people involved, their effort, the setbacks, the battles with referees and final celebration. Important not to forget the stories behind any paper!

I’ve been enjoying the Apple Intelligence summaries of iMessages. But it gave me a fright when we were planning a trip to my mother-in-law’s and not sure whether to take some lunch as she hadn’t phoned to confirm. The AI message from my wife flashed up as “mum unresponsive, not taking food”

How SPPIRIT is transforming early career profiles in Parasitology in Scotland

www.cell.com/action/showP...

Same here! Strangely a critique from another customer in the gents bathroom afterward was “it wasnt very realistic” 🤯

Many thanks to the @siegel-lab.bsky.social, to our collaborators @allshire-lab.bsky.social and @keithrmatthews.bsky.social,and to the funding agencies that supported this project.

(And a lovely stocking filler for the Allshire/Matthews lab collaboration)

Inter-chromosomal transcription hubs shape the 3D genome architecture of African trypanosomes - Nature Communications Decoding the role of inter-chromosomal DNA-DNA interactions remains challenging. Here, the authors use Micro-C to study the T. brucei genome architecture at high resolution and reveal an intricate net...

Congratulations to all at the Siegel group - Christmas comes (a little) early!

www.nature.com/articles/s41...

Genes linked to deadly parasites’ spread beyond Africa identified.

Parasites that cause the deadly illness known as sleeping sickness can spread beyond their native Africa as a result of mutations to key genes.

@keithrmatthews.bsky.social
@goldrieve.bsky.social

Full article: shorturl.at/9jlGS

Mechanisms of life cycle simplification in African trypanosomes - Nature Communications African trypanosomes can reduce their requirement for tsetse fly transmission, allowing an expanded geographical range. Here, molecular analyses of field and laboratory selected lines has identified a...

Excited to share our work on life cycle simplification (monomorphism) in Trypanosoma brucei in Nature Comms @natureportfolio.bsky.social
www.nature.com/articles/s41...

Mechanisms of life cycle simplification in African trypanosomes Nature Communications - African trypanosomes can reduce their requirement for tsetse fly transmission, allowing an expanded geographical range. Here, molecular analyses of field and laboratory...

What good way to start with Bluesky!

Delighted to share our paper on how non-tsetse transmitted trypanosomes lose the ability to make stumpy forms (and adapt to the monomorphic life style) and so can spread outside Africa. A great reward after years of hard work from Guy Oldrieve !

rdcu.be/d13YK

Not sure I can carry off the Jack Sparrow persona but willing to try for the next School meeting….

@mjafreeman.bsky.social's BlueSky starter packs for 'mechanistic' biologists

Here’s my spreadsheet of starter packs (>80!) related to broadly ‘mechanistic biology’ plus some intriguing extras

Complete with collective nouns

I’ve been tracking these but now can’t keep up

Hope it’s helpful

2/2

docs.google.com/spreadsheets...