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Donate Weghorn

@weghornlab.bsky.social

Group leader at the Centre for Genomic Regulation (CRG), Barcelona, Spain. Interested in cancer evolution and human population genetics.

91 Followers  |  86 Following  |  2 Posts  |  Joined: 01.02.2025  |  1.6927

Latest posts by weghornlab.bsky.social on Bluesky

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πŸ¦ πŸ§«πŸ‘©β€βš•οΈ "Sin la microbiota no podrΓ­amos vivir, es esencial para nuestra salud". Puedes recuperar la charla completa con la investigadora y microbiΓ³loga @mireiavallesc.bsky.social, y la cirujana Lola de la Puerta en πŸ‘‰ www.ondacero.es/programas/ju...

18.02.2025 12:09 β€” πŸ‘ 52    πŸ” 13    πŸ’¬ 1    πŸ“Œ 1
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Dissecting DNA-mismatch-repair-driven mutational processes in human cells Mismatch repair (MMR) is a crucial DNA repair pathway that maintains genomic integrity by correcting replication errors and various forms of DNA damage. MMR deficiency (MMRd) leads to increased mutati...

Very happy to announce our paper on mutational signatures caused by mismatch repair knockouts. We find SBS57 is driven by alignment errors in MMR-deficient cells, experimentally confirm the association of MMR with SBS1 & expose differences between in vitro and in vivo MMR loss: tinyurl.com/ycyprxme

18.02.2025 09:26 β€” πŸ‘ 11    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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Transcription start sites experience a high influx of heritable variants fuelled by early development Mutations drive evolution and genetic diversity, but the impact of transcription on germline mutagenesis remains poorly understood. Here, we identify a hypermutation phenomenon at transcription start ...

Did you know that transcription start sites harbor a huge excess of germline variants? Turns out this is driven by (divergent) transcription, mitotic, but not meiotic(!), double-strand breaks and early mosaic variants. Read the full story here: www.biorxiv.org/content/10.1...

06.02.2025 09:22 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 0    πŸ“Œ 1
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🐦 Calling all Early Birds! ​
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Hurry up and seize the opportunity to participate in the upcoming ESEB Congress, set in the vibrant city of Barcelona πŸŒŸβ€‹
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🎟️ Secure now your place at the best possible price πŸ‘‰πŸ» eseb2025.com/registration...
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#ESEB2025 #Biology #Evolution #Genomics

04.02.2025 11:22 β€” πŸ‘ 26    πŸ” 36    πŸ’¬ 0    πŸ“Œ 1

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