Matthew Hahn

Rapid compensatory evolution within a multiprotein complex preserves telomere integrity Intragenomic conflict with selfish genetic elements spurs adaptive changes in subunits of essential multiprotein complexes. Whether and how these adaptive changes disrupt interactions within such comp...

How to keep in step when your (protein) partner speeds up…

Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection.

Congrats to whole team!

www.science.org/doi/10.1126/...

Sonoran Desert landscape looking west across Avra Valley from Tucson Mountain Park. In the foreground, a desert trail winds through cholla cacti, saguaros, ocotillo, and native shrubs. The valley stretches to distant mountain ranges on the horizon under a dramatic sky of blue patches and white cumulus clouds with rays of light breaking through.

Please pass along - We've extended the CAMBIUM fellowship deadline to December 15! Our NSF NRT supports new grad students to harness biodiversity big data to adapt to & mitigate climate change impacts. Great fit for evolutionary genomics, bioinformatics, ecology & more. cambium.arizona.edu 🧬🌐🌎

OMG

Hertha Berlin!

Adversarial Poetry as a Universal Single-Turn Jailbreak Mechanism in Large Language Models We present evidence that adversarial poetry functions as a universal single-turn jailbreak technique for Large Language Models (LLMs). Across 25 frontier proprietary and open-weight models, curated po...

absolutely LOVE this preprint on tricking LLMs using poetry:
arxiv.org/abs/2511.15304
Like magic spells, you need to use the correct pentameter or the demon won't listen

"Releasing the Epstein files causes autism" claims Trump

Read this story in The Chaser Annual 2025, available now: chasershop.com/products/the...

BARISTA — Bioinformatics AggregatoR something something …

"Our paper describes 10.111/jez3471, which is much more powerful and accurate than either 10.124/uje569.1 or 10.193/genetics/10025"

must be!

Look-up your software name before publishing it!

I'm pretty sure there's another one, too, but I couldn't find it immediately. But 5 is enough!

CAFE: an integrated web app for high-dimensional analysis and visualization in spectral flow cytometry AbstractMotivation. Spectral flow cytometry provides greater insights into cellular heterogeneity by simultaneous measurement of up to 50 markers. However,

and CAFE #5:

academic.oup.com/bioinformati...

CAFE: a software suite for analysis of paired-sample transposon insertion sequencing data AbstractSummary. Sequencing of transposon insertion libraries is used to determine the relative fitness of individual mutants at a large scale. However, th

CAFE #4:

academic.oup.com/bioinformati...

CAFE: aCcelerated Alignment-FrEe sequence analysis Abstract. Alignment-free genome and metagenome comparisons are increasingly important with the development of next generation sequencing (NGS) technologies

CAFE #3 (in NAR, but still):

academic.oup.com/nar/article/...

CaFE: a tool for binding affinity prediction using end-point free energy methods Abstract. Summary: Accurate prediction of binding free energy is of particular importance to computational biology and structure-based drug design. Among t

CAFE #2:

academic.oup.com/bioinformati...

(Not finding the link to it, but of course we also published an updated version in Bioinformatics, too.)

Now for the fun part:

CAFE: a computational tool for the study of gene family evolution Abstract. Summary: We present CAFE (Computational Analysis of gene Family Evolution), a tool for the statistical analysis of the evolution of the size of g

JJ, stopping subtweeting me!

All joking aside, this is a favorite topic of mine, because of our software, CAFE:

academic.oup.com/bioinformati...

twin fox kits, grunewald berlin

Photo of my flat white

Kaffeehaus

Gus absolutely ascended. Volume up.

The Onion: DHS: ‘Daycare Workers Have Walked Freely in This Country For Far Too Long’

How to apply Learn how to apply to the Common Themes in Reproductive Diversity graduate program at Indiana University with detailed steps, requirements, and deadlines.

If you're looking for a #postdoc but aren't quite a fit for my lab, check out this exciting opportunity via IU's Common Themes in Reproductive Diversity group! 2-year NIH traineeship to work on one of the group's core themes. Details here! ctrd.indiana.edu/how-to-apply/

Now in Evolution: academic.oup.com/evolut/artic...

This paper started when @3rdreviewer.bsky.social, Mike, and I had a lunch at which there was a lot of, "What do you mean when you say X?" Fun to spend time thinking about when terms get too muddy, and great work by Drew to pull it all together!

Low tide, Normandy

La digue

Just now realizing that most of the French I know comes from “Three Feet High and Rising”…

Simons Postdoctoral Fellowships in Plant Biology Simons Postdoctoral Fellowships in Plant Biology on Simons Foundation

Great new postdoc fellowship for foundational plant research.
If you’re into genetics and genomics of plant reproductive evolution or adaptive convergence (incl in the cool and charismatic nightshades!) I’d be happy to talk about possible projects!
www.simonsfoundation.org/grant/simons...

That’s why I’m having a wheat beer :)

Biergarten nummer acht

Total solar eclipse triggers dawn behavior in birds: Insights from acoustic recordings and community science On 8 April 2024, a total solar eclipse disrupted light-dark cycles for North American birds during the lead-up to spring reproduction. Compiling more than 10,000 community observations and artificial ...

I have to fan-girl for a minute here. My friend @rosvall-lab.bsky.social built an app to gather data on bird behavior during the 2024 solar eclipse. 10,000+ citizen scientists contributed (including my kids), and the resulting paper was published in Science today!

www.science.org/doi/10.1126/...