Dr. Jake P. Mann

I am excited to have arrived in Helsinki for @espghansociety.bsky.social Annual Meeting.

I’ll be presenting some more of our biliary atresia data and recording a very exciting in-person version of the ESPGHAN podcast.

Genes that cause severe liver disease in children also influence risk and severity of common liver conditions in adults Background and aims Rare, pathogenic variants in multiple genes can cause severe liver disease, requiring transplantation in childhood, but it is unclear whether common variants in the same genes conf...

Here's a preprint of our work where we found that most genes which cause monogenic, severe liver disease also affect the onset and/or severity of liver-related traits in adults.
[Not yet peer reviewed.]
doi.org/10.1101/2025...

Thanks! I suggest annotating the axis on the figure next time.

Important stuff, but what is the x-axis here? It’s hard to interpret the graph otherwise.

I’m at @easlnews.bsky.social Congress in Amsterdam this week and sharing some of our biliary atresia data tomorrow

Working ‘on’ and ‘in’ the lab [Blog 021] – Dr. Jake P. Mann Failing to keep up with the workload as an early career clinical academic

jakepmann.com/working-on-a...

In 2024, Jasmin Paris made history by becoming the first woman to finish the Barkley Marathons, widely known as one of the hardest races in the world and a d... The Finisher: Jasmin Paris and the Barkley Marathons (Full Documentary)

The Finisher: Jasmin Paris and the Barkley Marathons. A wonderful film about wonderful people, and an incredibly inspiring Jasmin.

Here we are in Spanish talking liver health. #WorldLiverDay

I would define inflammation to encompass fibroblast activation so the two are intimately linked. Precisely what flavour of inflammation is a different question, and whether it can be detected with our standard histopathological assessment.

Paediatric Liver Transplantation: A new perspective💡

How common is graft fibrosis in young recipients - and what does it mean long term?💭

Join Dr Steffen Hartleif on the latest #ESPGHAN podcast as he explores future strategies in immunosuppression.🔍

Listen now🎧 ow.ly/LWkE50Vlk1T

I remember seeing this work presented last year and it’s stunning.

2nd run of Visium HD complete 🫡

Love this ...

The downside of being totally focused on functional experiments for my fellowship application is that I have become a '40 unread emails' person

And here I am thinking that my multicolour immunofluorescence is pretty

The real question is ‘will I ever find a paper that Alex (Knisley) thinks is free of major flaws?’

I’m back up in Edinburgh this week learning new spatial techniques and using some very rare paediatric samples.

All round quite exciting.

I _think_ we needed to dilute our samples a bit more

Anyone interested in working with me at Institute of Metabolic Science - Metabolic Research Laboratories, University of Cambridge, on how AMGEN's new obesity drug MariTide works? I have a 3 year postdoc position available! Deadline March 31st! please share www.jobs.cam.ac.uk/job/50529/

True. I feel bad about the volume of steroids some of these kids have.

I know the nephrologists have some evidence to use one-off ritux in nephrotic syndrome so I would be interested to see the effect.

(Hopefully not devastating sepsis.)

The study I want to see is a one-off dose of rituximab as induction then low dose pred + aza vs standard of care.

We give a lot more in kids. Usually 1mg/kg up to a maximum of 40mg/day at induction, then taper weekly as the enzymes improve.

I know I'm biased, but I'd say this is a particularly good one.

Keep sending me your feedback and requests!

Cancer Research UK Clinical PhDs at the University of Birmingham A prestigious Cancer Research UK-funded doctoral training programme offering fully funded non-clinical and clinical PhD fellowships based at the CRUK Birmingham Cancer Centre.

The CRUK Clinical PhD Programme at @unibirmingham.bsky.social is open for applications. This is an amazing opportunity.

If you're interested in applying, then I have project around the immunology of hepatocellular carcinoma (and also some HCC GWAS hits to follow-up) so get in touch!

Human-correlated genetic models identify precision therapy for liver cancer - Nature As proof of principle, an analysis using a suite of human-aligned immunocompetent mouse models of hepatocellular carcinoma identifies a promising therapeutic candidate, cladribine, which acts in a highly effective subtype-specific manner in combination with standard-of-care therapy.

Nature research paper: Human-correlated genetic models identify precision therapy for liver cancer

https://go.nature.com/41qNkbs

I’m enjoying Tim Urban’s book and I’m doing my best to follow his advice

“What if I’m wrong about some of what I think?”

🚨🚨Job Alert🚨🚨
Do you have skills in computational biology? Do you want to work on somatic mutations in #hcc?? Do you want to work in an international collaboration with @s-j-aitken.bsky.social? Come and join us in Cambridge!
🗓️ Closing date 31/Mar/2025
www.jobs.cam.ac.uk/job/50461/

I’m coming to conclusion of a GWAS project and only now truly starting to understand what pruning and fine-mapping means.

And LocusZoom is wonderful.

This is very different to the serious experiments needed to actually test a hypothesis: blinded, randomised, multiple exactly identical replicates.

I find that making a distinction helps make the work more fun.

I like to differentiate between the ‘messing around’ experiments and the ‘proper’ ones.

Much of the time in the lab I’m trying new stuff, testing meddling around with the protocol and seeing if there’s any hint it works. It’s low risk and really fun.