Daniyal Jafree

I'll soon be advertising for a 3 year postdoc to join our lab at @edinuni-irr.bsky.social exploring #macrophages in salivary gland #development. Candidates should have a strong background in immunology/macrophage biology and/or developmental biology & key skills as below. Informal enquiries welcome!

And last (but definitely not least) thanks to the amazing scientists at David Long’s lab at UCL, who worked hard to wrap up this work whilst I stumble through clinical training (4/4)

Thanks to our collaborators, especially the Ruhrberg Lab at UCL, the Riley Lab at Oxford, @siegenthalerlab.bsky.social and others for providing the support to make this work a reality. We are generous for funding from @goshcharity.bsky.social, @wellcometrust.bsky.social & @kidneyresearchuk.org (3/4)

A UCL Bogue Fellowship enabled me to travel to the Rosenblum Lab @uoftpress.bsky.social in Canada to complete these experiments, which opened up a new collaboration between two internationally recognised centres in childhood kidney disease, @greatormondst.bsky.social & @sickkidsto.bsky.social (2/4)

Genetic lineage tracing identifies intermediate mesoderm as a novel contributor to mammalian kidney lymphatics The lymphatic vasculature is essential for fluid homeostasis, immune regulation and possesses diverse organ-specific functions. During development, lymphatic endothelial cells (LEC) arise from multipl...

Excited to share our new collaborative preprint between @uclnews.bsky.social and @sickkidsto.bsky.social 🥳

We found that kidney lymphatic vessels, an emerging target in kidney diseases, partly arises from the same group of cells that give rise to the kidney

www.biorxiv.org/content/10.1...

(1/4)

🧪 Job alert 🔊 we are hiring a Research Assistant - join the Simões Group at DPAG-IDRM @ox.ac.uk supporting #cardiovascular development and regeneration research, working with #zebrafish and #human stem cell systems: my.corehr.com/pls/uoxrecru... @oxforddpag.bsky.social @idrm.ox.ac.uk (1/4)

PhD position available in our team @dublincityuni.bsky.social from September. Please share/ contact me for informal enquiries.

Image captured by a light-sheet microscope showing the arterial tree of an adult mouse kidney in magenta

For #FluorescenceFriday I'm sharing the fantastic work of postdoc Sarah McLarnon! A follow up to our '23 Development paper where we asked: Does precise vascular patterning matter for function and what happens after ischemic injury? The results were surprising! journals.physiology.org/doi/full/10....

An RNA transmethylation pathway governs kidney nephrogenic potential - Nature Communications The mechanisms governing kidney nephrogenic capacity are incompletely understood. Here, the authors reveal that METTL3-dependent RNA transmethylation is both necessary and sufficient to promote nephro...

Thrilled to share our new work in Nature Communications!

We discovered how methionine → SAM → METTL3 → RNA methylation axis guides kidney development, especially nephron progenitor differentiation. #Nephrology #Epitranscriptomics

Here’s a quick breakdown

www.nature.com/articles/s41...

I’m grateful for the mentors and colleagues (many who aren’t yet on this platform 👀), who have all collectively given me the support, guidance and motivation I needed to get here

Always looking for new collaborations and ideas, if you’re interested in teaming up then please reach out! 🙌🏽
(4/4)

I’m so grateful for this opportunity - it supports building a research agenda and, in parallel, allows me to continue clinical and leadership training

There are very few such opportunities for those who want to integrate post-doc research w. very early clinical training. I hope this changes!
(3/4)

I am also linking up with the MBPhD programme, from which I graduated, to support and mentor current students and recent grads

Ultimately, I want to find ways to amplify MBPhD students in the UK and help them navigate the barriers to becoming clinician- / surgeon-scientists. Watch this space!
(2/4)

Delighted to be a Accelerator Award recipient @wellcometrust.bsky.social 🥳

I’ll work at @uclnews.bsky.social + @sangerinstitute.bsky.social, diving into how lymphatic vessels regulate immunity, whilst building clinical experience at @greatormondst.bsky.social

wellcome.org/grant-fundin...
(1/4)

These findings reveal a window for interventions to restore the microvasculature

Thanks to our many collaborators, our funders (@kidneyresearchuk.org, the UK PKD Charity, @wellcometrust.bsky.social, The Rosetrees Trust, The Foulkes Foundation) & to the patients and relatives who motivate us (5/5)

We found that the kidney microvasculature in humans with PKD has a unique molecular fingerprint. In mice, abnormalities of the kidney microvasculature occurred early (like the striking results in this image). Importantly, these changes occurred before irreversible damage set in (4/5)

To address this, we used various cool techniques, including:

i) Single-cell genomics to profile kidney microvasculature in patients with PKD 🧬 🫘
ii) A mouse model to explore early disease stages 🐭
iii) 3D imaging and MRI to assess vascular structure and function 🔬 (3/5)

Though vascular issues are well documented in patients with PKD, we know surprisingly little about what happens to the kidney’s microvasculature. These are tiny, specialised vessels crucial for normal kidney function (2/5)

Thrilled to share a new paper from my PhD in David Long’s lab at UCL, published in the Disease Models & Mechanisms journal!

doi.org/10.1242/dmm....

We studied kidney microvasculature in polycystic kidney disease (PKD), the most common genetic cause of kidney failure (1/5)