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Anthony Schuller

@aschuller17.bsky.social

Director of Biology @ Interdict Bio | Previously @ Nogales Lab (Berkeley), Schwartz Lab (MIT), Green Lab (Johns Hopkins) | Drug discovery, ribosomes, protein & RNA biochemistry, cryo-EM, cryo-ET.

103 Followers  |  156 Following  |  1 Posts  |  Joined: 22.01.2025  |  1.3706

Latest posts by aschuller17.bsky.social on Bluesky

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Attacking Estrogen-Receptor-Positive Breast Cancer

This one is mostly about the title subject (featuring a very interesting compound from academia) but it’s also about attacking the NIH:

24.01.2025 19:16 β€” πŸ‘ 47    πŸ” 18    πŸ’¬ 4    πŸ“Œ 4

"On a molecular level, our structural studies reveal that interdictors bind in a linkerless heterobifunctional manner to both the rRNA and the nascent peptide chain ... much the way a PROTAC can be modularly designed and constructed"

10.01.2025 20:00 β€” πŸ‘ 12    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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Context-dependent translation inhibition as a novel oncology therapeutic modality Inhibitors of protein synthesis, including anisomycin, homoharringtonine, and other natural products bind in the peptidyl-transferase center (PTC) of the eukaryotic ribosome to inhibit translation. Re...

Selective translational stalling is coming of age...

doi.org/10.1101/2025...

17.01.2025 12:56 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 1
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Context-dependent translation inhibition as a novel oncology therapeutic modality Inhibitors of protein synthesis, including anisomycin, homoharringtonine, and other natural products bind in the peptidyl-transferase center (PTC) of the eukaryotic ribosome to inhibit translation. Re...

Excited to share the 1st preprint from our incredible team at Interdict Bio as we progress novel, small-molecule sequence-selective inhibitors of translation toward the clinic to address difficult to treat cancers!Β #ribosome #interdictor
Check out the preprint here: www.biorxiv.org/content/10.1...

22.01.2025 04:09 β€” πŸ‘ 19    πŸ” 10    πŸ’¬ 1    πŸ“Œ 3

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