Attacking Estrogen-Receptor-Positive Breast Cancer
This one is mostly about the title subject (featuring a very interesting compound from academia) but itβs also about attacking the NIH:
24.01.2025 19:16 β π 47 π 18 π¬ 4 π 4
"On a molecular level, our structural studies reveal that interdictors bind in a linkerless heterobifunctional manner to both the rRNA and the nascent peptide chain ... much the way a PROTAC can be modularly designed and constructed"
10.01.2025 20:00 β π 12 π 3 π¬ 0 π 0
Context-dependent translation inhibition as a novel oncology therapeutic modality
Inhibitors of protein synthesis, including anisomycin, homoharringtonine, and other natural products bind in the peptidyl-transferase center (PTC) of the eukaryotic ribosome to inhibit translation. Re...
Excited to share the 1st preprint from our incredible team at Interdict Bio as we progress novel, small-molecule sequence-selective inhibitors of translation toward the clinic to address difficult to treat cancers!Β #ribosome #interdictor
Check out the preprint here: www.biorxiv.org/content/10.1...
22.01.2025 04:09 β π 19 π 10 π¬ 1 π 3
(bio)physicist, fascinated by cell and single molecule mechanics
Cancer researcher, RNA biologist, and all round science geek, based at the University of Bristol. Ribosomes FTW.
Group leader at the Francis Crick institute and head of the Protein Biogenesis lab. Interested in protein folding, ribosomes and molecular chaperones.
Mostly #cryoEM-related tweets. Group leader at a biotech company in the Bay Area. Views are my own.
https://github.com/warpem/warp
Metabolic neurochemist investigating the impact of HIV infection on brain lipids |Postdoc at Emory University in Dionna Williams, Ph.D. Lab | Hopkins BCMB Alum
Biochemistry & instrumentation reporter at Chemical & Engineering News. Signal: Laurel_Oldach.07
www.thebarneslab.com
Assistant Professor of Biology, Stanford University
Full Prof @BZH, Heidelberg Uni π©πͺ, before in π³π± andπ¨π, orig. fromπ΅πΉ| #FirstGen, Passion for #MembraneProteins, #cryoEM, #StructuralBiology, #Biochemistry. Mentor & Mother | she/her
ππΌ www.paulinolab.com
grigoriefflab.umassmed.edu/
Structural biologist, professor, NYU School of Medicine. Alum of: Skirball Institute, EMBL, Univ Stockholm, Acad Sin, NEU. Personal account. https://scholar.google.com/citations?user=lX2sB0sAAAAJ&hl=en
Associate Professor of Biochemistry at Washington University in St. Louis #WashU.
#CryoEM studies of native #microtubules and #cilia related complexes
lab website: http://zhangrui.wustl.edu
RNA biochemistry | Translational control | Single-molecule approaches | Dogs | Cycling. Assistant Professor, Basic Sciences Division, Fred Hutch
Postdocking in Helmholtz Zentrum Munich researching pancreas biology.
Interests: developmental biology, endocrinology, diabetes research, teaching and learning in higher education
Alexander von Humboldt and MSCA fellow
PhD student in @balikovalab.bsky.social at @czechacademy.bsky.social of Sciences, BIOCEV, @charlesuni.cuni.cz in Prague
π antibiotics π ribosome
𧫠resistance 𧬠ABC-Fs
π¦ staph βοΈ cryo-em
@mbuavcr.bsky.social
@sciencecharles.bsky.social
Professor and Chair @UCSF/@UCSF_BTS - dynamic structural biology and open science - (he/him) - fraserlab.com
Medicinal chemist / chemical biologist, author of βIn the Pipelineβ at http://science.org/blogs/pipeline. derekb.lowe@gmail.com and on Signal at Dblowe.18
All opinions are mine; I donβt speak for my employer in any way.
Professor of Chemical Biology and Molecular Therapeutics at UC Berkeley
Reporting from the frontiers of health & medicine.
We're where the business of medicine gets answers. An independent news media organization covering biotech, pharma, science, policy, finance, venture capital and markets, and how they drive the life sciences industry. Read us at www.endpts.com.