Amir Argoetti

ואז הוא/היא חוזרת לגן ואחרי יומיים חוזרת
שוב חולה והבית שוב משותק לשבוע 😟

Pls. share widely

Calling all transposon fans & lovers of genetic innovation

MOBILE GENOME welcomes you in Heidelberg, Nov. 4–7 2025

→ Vibrant & friendly community
→ Cutting-edge talks from mechanisms to physiology
→ Plenty of surprises (TEs never stop innovating)

submit abstract by July 29

🚨Our post is now live! Apply and join us!

my.corehr.com/pls/uoxrecru...

Unique genetic mechanism that protects cells against viruses discovered Researchers at the Technion-Israel Institute of Technology have discovered a unique genetic mechanism that provides cells with rapid and efficient protection against viruses.

A unique genetic mechanism has been identified that enables cells to rapidly and efficiently counteract viral infections, potentially paving the way for novel therapeutic strategies. doi.org/g82vd4

Unique genetic mechanism that protects cells against viruses discovered Researchers at the Technion-Israel Institute of Technology have discovered a unique genetic mechanism that provides cells with rapid and efficient protection against viruses. The findings could lead t...

Unique genetic mechanism that protects cells against viruses discovered #STAT3 #MECFS #LongCovid

phys.org/news/2025-01...

Any recommendations for a membrane dye compatible with HCR/smFISH?

שפעת B זה גם נדיר, אז בכלל מעניין 😄

שתרגיש טוב!

אתה גם אבא עכשיו!! 😍😍😍
מזל טוב!

lncRNA NORAD modulates STAT3/STAT1 balance and innate immune responses in human cells via interaction with STAT3 - Nature Communications Long non-coding RNA (lncRNA) has diverse functions. Here the authors show that a lncRNA, NORAD, interacts with an immune transcription factor, STAT3, to facilitate STAT3 nuclear import and thereby mod...

lncRNA NORAD modulates STAT3/STAT1 balance and innate immune responses in human cells via interaction with STAT3
www.nature.com/articles/s41...
@naturecomms.bsky.social
@aargoetti.bsky.social

תודה רבה! ☺️

תודה ענר! ☺️
טוב לשמוע ממך שוב

Thanks Oded! 🙏🏻☺️

Thank you Gal! 🙏🏻

lncRNA NORAD modulates STAT3/STAT1 balance and innate immune responses in human cells via interaction with STAT3 - Nature Communications Long non-coding RNA (lncRNA) has diverse functions. Here the authors show that a lncRNA, NORAD, interacts with an immune transcription factor, STAT3, to facilitate STAT3 nuclear import and thereby mod...

7/7 I’d like to thank my mentor, Yael, and all my friends who worked with me—Galia, Noa, Dor, Hadas, Tami, and Tamar. This work wouldn’t have been possible without their incredible support!

@biologytechnion.bsky.social

www.nature.com/articles/s41...

6/7 The STAT3 binding site in NORAD is located near an Alu element, which is conserved only in primates that have Alu in NORAD.
We propose that the introduction of an Alu into NORAD enabled its ability to bind STAT3, granting it a novel function in antiviral defense.

5/7 Interestingly, while the other functions of NORAD are conserved, we found no interaction between NORAD and STAT3 in mouse cells and no immune response upon NORAD knockdown in mice.

4/7 We discovered that NORAD levels decrease upon viral infection (SINV, SARS-CoV-2, HSV1, and IAV) in cell culture and in COVID-19 patients, and NORAD shows an inverse relation with the activation of the Interferon pathway.

3/7 STAT3 binds to the promoters of interferon-stimulated genes (ISGs) and inhibits their transcription.
In the absence of NORAD, STAT3 exits the nucleus, allowing STAT1 to bind in its place and activate the antiviral response.

2/7 In our previous paper, we found that the STAT3 interacts with RNA in hESCs and directly binds NORAD lncRNA, already known for its role in genome stability.
In this paper, we further investigate this interaction and reveal that NORAD is required for STAT3 nuclear localization.

1/7 I’m excited to share our paper, describing the majority of my PhD, now published in
@naturecomms.bsky.social
!
We present how the lncRNA NORAD interacts with STAT3 to regulate the antiviral response in human cells. A 🧵

www.nature.com/articles/s41...

Does anyone know of a gorilla cell line?
And if so, does anyone in Israel have one and is willing to give us a vial?

The link is broken 😅