Khansa Saadallah

On cell extrusion in the #intestine!
After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report:

3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look!
www.biorxiv.org/content/10.1...

AML patient blasts exhibit polarization defects upon interaction with bone marrow stromal cells.

www.embopress.org/doi/full/10....

Work by Manuel Thery @manuelthery.bsky.social @institut-leucemie.bsky.social and co-workers.

AML patient blasts exhibit polarization defects upon interaction with bone marrow stromal cells | EMBO reports imageimageHSPCs polarize in contact with bone marrow stromal cells constituting their niche. This study analyses the polarity of hematopoietic cells from AML patients using artificial micro-niches and...

Our latest study about the polarization capacities of leukemic blasts was published today in #EMBOReports. www.embopress.org/doi/full/10.... @manuelthery.bsky.social @el-khansa.bsky.social LinaBenajiba @lobrylab.bsky.social

⭐️ Please Fwd. Are you in Paris on 16th May? See👇 poster of symposium on « Information processing in biological systems » @collegedefrance.bsky.social Fantastic line of speakers 🤩.
It is free, w/o registration, and it will be exciting.m!
Follows from my series of lectures at CdF last fall.

Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.

Mitochondria with mtDNA mutations can be transferred from cancer cells to tumour infiltrating lymphocytes so they don't undergo mitophagy. @Ikeda
www.nature.com/articles/s41...

N-cadherin crosstalk with integrin weakens the molecular clutch in response to surface viscosity - Nature Communications The crosstalk between cell-cell and cell-matrix adhesions regulates stem cell fate. Here, the authors reveal a critical role for matrix viscosity in controlling this crosstalk, which they explain via ...

Interested in how #stemcells sense their environment? Check out our work showing how #ECMatrix viscosity regulates #mechanosensing and #differentiation 🧪 Led by @theglasgowcemi.bsky.social @uofglasgow.bsky.social in collaboration with IBEC @natureportfolio.bsky.social
www.nature.com/articles/s41...