Joshua Fein

Interestingly we’ve seen some (single digit) examples of what seems like the opposite as well—relapse shortly after vaccine or worsening of stable aplastic anemia on CsA. Fascinating immunobiology here.

Still can’t believe this isn’t the world’s most elaborate April fools joke… in October. Can’t wait to try it, and put in an order for a tshirt 🙃 thanks for all you do for the community to keep us sane: both the memes and the tools/wisdom!

Congrats to the authors on this huge accomplishment. Fascinating and so much to build on here.

Has anyone had success 3D printing storage boxes for -80s? What fiber have you used? any special settings to reinforce?
I'm thinking of making either custom inserts or entire boxes to better keep track of which sample goes where...

Industry friends, now is the time for MUCH more speaking out on behalf of academic colleagues under duress. Here are core open source methods that many of your products doubtlessly depend on either directly or indirectly (see en.wikipedia.org/wiki/HMMER) being abruptly defunded. Make noise.

The ‘Profound’ Experience of Seeing a New Color The ecstasy of “olo”

Reminds me of Oliver Sacks’ musings on seeing azure.
This will surely be commercialised and available as an “experience” (hopefully safely) around the world soon, but absolutely sign me up.

I think the reason I like #systemsimmunology #cshlsysimm is because network diagrams are so pretty.

This is simply insanity.

Congrats!

Bach: Keyboard Concertos, BWV 1052, 1053, 1054 & 1056 by Beatrice Rana - Apple Music Classical Listen to Bach: Keyboard Concertos, BWV 1052, 1053, 1054 & 1056 by Beatrice Rana. 2025. 12 tracks. 1 hour, 2 minutes.

This disc is a revelation.
I thought I knew these pieces-the D minor concerto was one of the first pieces I fell in love with as a kid.
Beatrice Rana’s playing is simply enchanting.

Does anyone have experience with momelotinib for AGvHD in MF patients?

Minnie Lab - Junior, Assistant, or Associate Specialist University of California, San Francisco is hiring. Apply now!

I’m very specifically looking for a tech with mouse experience for my new lab! Message me or apply through the link if you’re interested!

aprecruit.ucsf.edu/JPF05438

Excited to attend #cshlsysimm next week. I am just starting to find my way in this fascinating field and look forward to learning from the extraordinary lineup of speakers! Please reach out if you’ll be there—looking forward to connecting. @cshlnews.bsky.social

mad scientist wearing a bowtie fishing and catches a beaker of orange bubbling liquid

I remain strongly in favor of fishing expeditions.

Oof. So much for my theory that the more you can identify a cartoon character in your UMAP the better your results.
If there is a publicly shared video of the talk please post the link!

Neolithic people working with mortar and pestle on an ATAC-seq analysis. An older man holds a bottle labeled Tn5 Transposase

In light of recent news regarding funding, I have asked ChatGPT to help figure out how to do ATAC-Seq with only an abacus and stone tools.

An aging bone marrow exacerbates lung fibrosis by fueling profibrotic macrophage persistence Hematopoietic aging drives lung fibrosis and profibrotic macrophage influx, stalling their maturation via reduced Treg-derived IL-10.

1/ Excited to share my first-ever first-author paper out now in Science Immunology! from @knapplab.bsky.social and co-supervised by @miershawig.bsky.social
We show that hematopoietic aging, independent of lung tissue aging, is sufficient to exacerbate fibrosis.
🔗 www.science.org/doi/10.1126/...

It dawned on me today that I really should’ve named one of my kids Luke, so that I could legitimately say “Luke, I am your father.”

Oh well.

Shame on me for living in the US Northeast and only visiting our neighbors twice in my life (and not in the last 20 years!) Québec City looks like a stunning place to live, though it'll take me some time to acclimate to the arctic.

Piano Sonata No. 3 in B Minor, Op. 58: II. Scherzo (Molto vivace) by Maurizio Pollini on Apple Music Song · 2019 · Duration 2:31

Today is another Chopin day.
Thank you, Maurizio Pollini.
music.apple.com/us/album/pia...

...O Canada, my future home and to-be-native land?

The Road to 1066: Anglo-Saxon Apocalypse (Part 1) Podcast Episode · The Rest Is History · 03/17/2025 · 55m

Highly recommended escape from these dark times.

Transcriptomic plasticity is a hallmark of metastatic pancreatic cancer Metastasis is the leading cause of cancer deaths; nonetheless, how tumor cells adapt to vastly different organ contexts is largely unknown. To investigate this question, we generated a transcriptomic ...

1) I am delighted to share a manuscript long in the making (7 years), elucidating the forces that shape metastatic adaptation PDAC using scRNA-seq across multiple organs from a rapid autopsy combined with a powerful new clonal phylogeny inference algorithm www.biorxiv.org/content/10.1...

Having determined that the transplant immunology community is shamefully lacking for pompously named journals, I propose the establishment of Acta Transplantiana A (solid organs) and B (haematopoietic tissues).
Paper distribution only, on heavy cream-coloured paper stock. Figures hand-drawn.

This looks fantastic. Have the perfect dataset to test it in, too.

Goya - Saturn Devouring His Son

I am struck by the aptness of Fareed Zakaria’s description of the United States in this conversation with @ezraklein.bsky.social

We are determined to devour the world that we created.

podcasts.apple.com/us/podcast/t...

Tragic Childhood Death from Measles Reminds Us That Some Don't Understand Either the Medical Significance or the Human Heart My ID colleague Dr. Adam Ratner, Chief of Pediatric ID at NYU Medical Center, just published an insightful and remarkably timely book called Booster Shots:  The Urgent Lessons of Measles and the Uncer...

If someone thinks the measles outbreak and childhood death in Texas are "not unusual" or "happens all the time", they are deeply misinformed. h/t @adamratnermd.bsky.social for the inspiration.

blogs.jwatch.org/hiv-id-obser...

A compendium of human gene functions derived from evolutionary modelling - Nature Evolutionary modelling and expert review are applied to integrate experimentally supported knowledge accumulated in the Gene Ontology knowledgebase to create a draft human gene ‘functionome’.

A compendium of human gene functions derived from evolutionary modelling @nature.com
www.nature.com/articles/s41...

Anyone have a nice public dataset of shotgun gut microbiome data specifically in GU malignancies treated with checkpoint inhibitors? Looking for something with published OS or PFS data for a little validation. Much obliged!