Giovanni Rabuffo

With deep gratitude to my extraordinary co-authors @MariannaAngiolelli, @FukaiTomoki, @GustavoDeco, @pierpasorre.bsky.social, and @davemomi.bsky.social
—this work would not have been possible without them.
Supported by the MSCA grant @ec.europa.eu and @upf.edu—more to come!

GitHub - grabuffo/State_Dependent_Brain_Stimulation: This repository includes the code required to reproduce the results in: "Targeting pre-stimulus brain states predicts and controls variability in s... This repository includes the code required to reproduce the results in: "Targeting pre-stimulus brain states predicts and controls variability in stimulation responses" - grabuffo/State_D...

Key message: variability is not just noise—it reflects structured brain dynamics that can be harnessed for more reliable, state-aware stimulation protocols.

Preprint: doi.org/10.1101/2025...
Code: github.com/grabuffo/Sta...

7/n

Not all networks behave the same. Sensorimotor regions showed stronger state-dependence than higher-order association areas, revealing a hierarchy—especially in SEEG analyses. 6/n

Conditioning stimulation on favorable pre-stimulus states reduced response variability by over 20%. This shows that brain-state monitoring can make interventions more reproducible, offering a concrete step toward refined closed-loop and precision neuromodulation. 5/n

Whole-brain context matters. When predictions are based only on activity close to the stimulation site, accuracy is limited. Expanding to include wider pre-stimulus dynamics across the whole brain consistently improves predictability of outcomes. 4/n

Across 125 candidate metrics, measures of synchronization, connectivity, and spatiotemporal signal diversity consistently predicted responses—sometimes explaining up to 80% of the variability within a session. 3/n

We analyzed a rare dataset: 36 patients, ~320 sessions, and more than >10,000 stimulations, combining intracranial and high-density EEG recordings. We asked: which pre-stimulus features are most reliable in predicting stimulation outcomes? 2/n

Pre-stimulus Brain States Predict and Control Variability in Stimulation Responses Does the ongoing brain state determine how it responds to localized electrical stimulation? This fundamental question has major implications for neuroscience and medicine, as stimulation outcomes rema...

🧠⚡️Brain stimulation is powerful, yet its effects are notoriously variable: identical parameters can produce very different outcomes. In our new preprint, we show how the brain’s state before stimulation helps explain and reduce this variability. 🧵1/n

doi.org/10.1101/2025...

Sis investigadors postdoctorals aportaran el seu talent a la UPF gràcies als ajuts Marie Curie 2024 Els seus projectes estan vinculats als departaments de Ciències Polítiques i Socials (Ona Valls i Cecilia Gebruers), Enginyeria (David Dalmazzo i Giovanni Rabuffo) i Medicina i Ciències de la Vida (Au...

Comença la #MSCA CAERUS, finançada per @horizoneu.bsky.social.
Amb supervisió de Gustavo Deco (@cbc-upf.bsky.social), G. Rabuffo @grabuffo.bsky.social millorarà les teràpies d'estimulació cerebral per pacients en coma o d’altres trastorns de la consciència.
➡️ www.upf.edu/web/focus/w/...

#RecercaUPF

Thrilled to finally share a huge piece of my PhD project!
Our paper “The Topological Architecture of Brain Identity” is now out on bioRxiv: biorxiv.org/content/10.1... 🧵 1/n

Rise in higher frequency oscillations in brain of a person in a disorder of consciousness given magic mushrooms 🍄✨

Find the full research “Psilocybin for disorders of consciousness: A case-report study” with the link in my bio ☝️ #psychedelics #neuroscience #researchpaper

🙏 Armelle Lokossou, Zengmin Li, Abolfazl Ziaee-Mehr, Meysam Hashemi, Pascale Quilichini, A. Ghestem, O. Arab, M. Esclapez, Parul Verma, Ashish Raj, @gozziale.bsky.social , @pierpasorre.bsky.social , Kai-Hsiang Chuang, Adriana Perles-Barbacaru, Angèle Viola, Viktor Jirsa, Christophe Bernard 🔥

Mapping global brain reconfigurations following local targeted manipulations | PNAS Understanding how localized brain interventions influence whole-brain dynamics is essential for deciphering neural function and designing therapeut...

After a long journey, our paper is officially out in PNAS! 🚀 Huge thanks to the team — excited to finally share it with the world. Check it out: www.pnas.org/doi/10.1073/...

I'll never stop being in awe of the brain. Raster of a single neuron in medial geniculate body responding to auditory tones.