Liz Wellberg

Cell populations in human breast cancers are molecularly and biologically distinct with age - Nature Aging Parsons and colleagues characterize age-associated changes in the tumor microenvironment of triple-negative and estrogen receptor-positive breast cancer using computational analysis of transcriptomic ...

Cell populations in human breast cancers are molecularly and biologically distinct with age

"how age affects cells in the breast tumor microenvironment or how they contribute to age-related pathology."

www.nature.com/articles/s43...

Elizabeth Wellberg @lwellberg.bsky.social & colleagues present a Review in the JCI series on Clinical innovation and Scientific Progress in GLP-1 Medicine:
GLP1 receptor agonists & cancer: current clinical evidence & translational opportunities for preclinical research: www.jci.org/articles/vie...

Many clinical studies have shown reduced cancer risk in people with diabetes of obesity taking GLP-1 family of drugs. A new JCI piece makes the case these drugs should be studied to reduce cancer in people without metabolic disease jci.org/articles/vie...

Will GLP-1 medicines modify the rates and/or outcomes of one or more #cancers A review on the biology, limitations of the data and the road ahead from @lwellberg.bsky.social and colleagues in JCI www.jci.org/articles/vie...

💰ECR grants for #FGF26 now available to help defray the meeting costs for those in junior faculty.

Details on how to apply - click here ➡️https://bit.ly/47ivjOf

⌛️Don't forget talk submission closes soon, submit your abstract now and join us in sunny Malta next May. 🌞
#FusionCellBio

📢🗓️SAVE THE DATE

We are very excited to announce that registration for #FGF26 is now open!!

Join our fantastic chairs and their incredible speaker line up in sunny Malta next May 🌞

🗓️ 07-10 May 26
📍 St Julian's, Malta
✍️ Sign up for updates: bit.ly/3IXaYFB
⌛️ Next deadline: 05 Nov 25
#FusionDevBio

Does anyone want to collaborate on a #breastcancer #obesity #immune project who has a PhenoCycler or can analyze more than 7 protein markers per slide at once? I ran into a road block. #Science

Thank you for submitting your Letter of Intent (LOI) to CZI. We appreciate your interest in our work. CZI has decided not to continue with the second round of its Science Diversity Leadership Awards. We are committed to supporting groundbreaking research that advances the frontiers of scientific knowledge in pursuit of our mission to cure, prevent, or manage all diseases by the end of the century. We will provide information on future funding opportunities. We look forward to staying in touch. Bil Clemons, Program Officer, CZI

Pretty sad. Just got the email that CZI is canceling the second round of Diversity Leadership Awards. Private industry will definitely not fill the hole that NIH and NSF are leaving. 😢💔

A few days ago my neighbor said she was furious but wasn't sure yet what to do. I told her there have to be lines or waves of resistance and when the group ahead of her needed a break, she can take over and will have learned more by then. A relay is the perfect analogy.

I'm in a red state (I'm not a republican) and it is terrifying here now. We feel helpless but some are speaking out as best we can. I wake up crying at night worried about my family's future but also about our country. It's gutting to see these men destroy our global relationships, all for power 😔

Despite the current uncertainty of being a scientist, I am excited to share our manuscript demonstrating an interesting mechanism of how swirling motion of breast cancer cells align collagen fibers radially at the tumor-stroma interface to enable their invasion (1/11) @thechaudhurilab.bsky.social

Centering myself in the kitchen today. I'll give sauerkraut another shot after something went very wrong last time. Science at home!

Matrix mechano-sensing at the invasive front induces a cytoskeletal and transcriptional memory supporting metastasis - Nature Communications Interactions with the extracellular matrix (ECM) control tumor proliferation, invasion and metastasis. Here, authors provide spatial information on ECM organization and how it influences tumor cell in...

🔔🧪 Super interesting paper from the Sanz-Moreno group showing that the #ECMatrix influences #tumour #dissemination, with distinct #structure in different tumour regions that then affect #invasion patterns.

#cancer #metastasis #mechanosensing
#mechanoregulation

www.nature.com/articles/s41...

Thanks friend 🩷

Science question... does anyone know what fraction (in general) of cholesterol is converted to steroid hormones in humans, vs other downstream cholesterol products? My husband says it's negligible... 😐 Does cholesterol go up after menopause in women?

Are you a senior PhD student or postdoc? Do you have a cool science story to tell? Do you want to visit Buffalo when the weather is perfect? Then apply for the Emerging Leaders Seminar Series at Roswell Park! DM or email me with questions. (RT please!)

www.roswellpark.org/education/pr...

I made a starter pack for mammary developmental and cancer biologists.

Tell me if you want to be added or suggest colleagues.

go.bsky.app/8ZbyV6c

Very proud of our 2 summer researchers, who worked in the lab between 1st and 2nd yr of med school. Great job at the symposium today, Michaela and Tom, and thank you for your hard work! Also thanks to Nisha and Jumana for volunteering to judge presentations 😎 #ProudPI

An estrogen receptor signaling transcriptional program linked to immune evasion in human hormone receptor-positive breast cancer https://www.biorxiv.org/content/10.1101/2024.11.23.619172v1 T cells are generally sparse in hormone receptor-positive (HR+) breast cancer, potentially due to li

An estrogen receptor signaling transcriptional program linked to immune evasion in human hormone receptor-positive breast cancer https://www.biorxiv.org/content/10.1101/2024.11.23.619172v1

Comprehensive single-cell aging atlas of healthy mammary tissues reveals shared epigenomic and transcriptomic signatures of aging and Cancer. #NatureAging #Aging #scisky #Medsky #News #Cancer

Open Access
www.nature.com/articles/s43...

Cancers adapt to their mutational load by buffering protein misfolding stress High mutational load tumors mitigate effects from protein-damaging mutations by up-regulating complexes that buffer against misfolding stress, revealing therapeutic vulnerabilities and suggesting disr...

Cancers adapt to their mutational load by buffering protein misfolding stress 🧪
doi.org/10.7554/eLif...

With holidays approaching I found this amazing person who makes #Pathology related art and gifts and wanted to share. Some of you make incredible images for your research. I'm always impressed with the art+science combo 🩷

lamellipodiumart.com

This is Ayla, named after my favorite book character (The Clan of the Cave Bear). She swims every day, no matter what. It's 57 degrees now, and the pool is frigid, but she just swam. Fitting, because Ayla in the book was famous for her daily swims, even breaking ice to get in #samandayla

In addition to science and gardening, I post about #samandayla and Ginger (no final # yet!) Front yard Paw Patrol reporting for duty, ready to alert about squirrels and falling leaves 🩷

First post. I'm working on a new strategy for setting and meeting goals. One personal goal is to read more books. To this end, I organized one of my bookshelves. Do you see one of your favorites? Stacks on the counter and what to put in the middle are in progress, but feeling centered now 😊