Rahul K

Congratulations @ivaskalab.bsky.social team for this study on the role of vibration in vocal cord cancer! Was a fun collaboration 🎤🎤

Hey Chromatin Friends!
Long time no chromatin question...
For many of you, CUT&x (RUN/Tag) works really well but some of you have had their frustrations with CUT and "gone back" to ChIP-Seq. Can you share your experiences in the comments!?
Would love to hear from you!
Sharing is appreciated : )

📢📢📢Lectureships at Bristol!📢📢📢

We're hiring 3 x lecturers (=assistant professor) in Biological Sciences, across the discipline.

Great department, great colleagues, great building, great city

Details here:
www.bristol.ac.uk/jobs/find/de...

So proud this multi-year effort is finally out. Led by my exceptional collaborator Joanna Buchthal, who put her blood, sweat, and literal tears into making a real impact for communities impacted by Lyme disease. bit.ly/MAT-tracking

More papers soon.

Learn more & support: miceagainstticks.com

Rapid directed evolution guided by protein language models and epistatic interactions Protein engineering is limited by the inefficient search through a high-dimensional sequence space to find combinations of synergistic mutations. Traditional approaches use stepwise mutation stacking,...

www.science.org/doi/10.1126/...

I can't take any credit, but I love this paper, which I believe coins the term xeno-learning.

Good impact narratives must connect to our everyday lives - LSE Impact Research impact is often communicated in abstract and bureaucratic language. To be meaningful it needs to connect to peoples' everyday lives.

👀ICYMI: "despite the emphasis on impact, its meaning remains abstract for non-specialist audiences."

#Impact #SciComm #PublicEngagement

I used Claude Opus 4.5/4.6 (and a bit of Codex GPT-5.3) to port edgeR to Python. See edgePython github.com/pachterlab/e...
This allowed me to develop a single-cell DE method that extends NEBULA with edgeR Empirical Bayes. All in one week. Details in doi.org/10.64898/202...

Thrilled to share our latest work "Recessive PPTC7 deficiency triggers excessive mitophagy to cause a severe inborn error of metabolism with hypomyelinating leukodystrophy" - a collaborative effort documenting the first cases of PPTC7 mutations in humans. 1/n
www.researchsquare.com/article/rs-8...

Lovely feature on the spectacular theoretical research led by my brilliant friend and colleague Anna Erzberger 🤩

Really excited to share the first preprint of my postdoc!! A huge thank you to our collaborators, the Niemi Lab powerhouse crew who were incredible helpful, and of course @nieminm.bsky.social who has been an AMAZING mentor through all the unexpected surprises and interesting discoveries we made!

Super cool paper on ephys in organoids out yesterday in nBME from the Rogers lab.

A CRISPR-based mitochondrial gene therapy tool derived by engineering guide RNAs Wang et al. systematically analyzed mitochondria-localized lncRNAs to reveal that RBP-motif recognition drives RNA mitochondrial translocation, leading to the engineering of an RNA mitochondrial targe...

A CRISPR-based mitochondrial gene therapy tool derived by engineering guide RNAs

www.cell.com/cell-reports...

Dominik S. Schmidt et al published about "Conductive emulsions with selective filler distribution as volume exclusion strategy in electrofluids" Find full text in Journal of Physics: Materials 9 (2026) 015019 doi.org/10.1088/2515...

Bettina Zimmer et al published about Carbon black (CB)-elastomer composites. Find full text and more information in Carbon Trends 23 (2026) 100623 doi.org/10.1016/j.ca...

There's an art to representing MS-based bioinformatics, and these authors have done an amazing job.

Glutamine metabolism tunes myeloid responses to drive resolution of inflammation during skin repair Xu et al. uncover how metabolites regulate cellular communication during inflammatory resolution and tissue repair in vivo. They find that glutamine metabolism alters chromatin accessibility and suppr...

Glutamine metabolism gives the immune system precision—quieting inflammation while rebuilding tissue!
Proud of my lab team for this exciting work as we venture into immunometabolism to learn how wound cells are fed!

www.cell.com/cell-reports...

I’m thrilled to share that I will join @gustaveroussy.fr as a Group Leader!

Our objective: to understand how mechanochemical feedbacks regulate tumor dynamics and plasticity, with the overarching goal of bridging tissue mechanobiology and tumor pathophysiology using human organoids.

Reflections on my 30+ years in mitochondrial research,
in @cp-trendsbiochem.bsky.social

linkinghub.elsevier.com/retrieve/pii...

Generative AI for synthetic biology: Designing biological parts, circuits, and genomes The convergence of generative AI and synthetic biology is transforming biological design, enabling the de novo creation of biological parts and systems with predictable, programmable function. Kim et ...

*Very* interested to see this, for all sorts of reasons.
www.cell.com/cell-systems...

Ancient co-option of LTR retrotransposons as yeast centromeres - Nature Evolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with re...

Our paper is now out in Nature:

“Ancient co-option of LTR retrotransposons as yeast centromeres”

www.nature.com/articles/s41...

A short thread on how retrotransposons helped give rise to yeast point centromeres.

1/14

New preprint from @kutseikin.bsky.social showing how pharmacologic inhibition of SLC33A1 activates IRE1/XBP1s signaling. w/ @enriquesaez.bsky.social @chrisgparker.bsky.social @landerlab.bsky.social @forlilab.bsky.social & the Birsoy lab (Rockefeller) Check it out👇

www.biorxiv.org/content/10.6...

Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now?
www.nature.com/articles/s41...

More functional data, many thousands of words removed, and a few other updates from last year's preprint.

Looking forward to this!

Experienced Post-Doc in Skeletal Muscle Molecular Physiology and Epigenetics (296037) | The Norwegian School of Sport Sciences Job title: Experienced Post-Doc in Skeletal Muscle Molecular Physiology and Epigenetics (296037), Employer: The Norwegian School of Sport Sciences , Deadline: Wednesday, March 11, 2026

Now recruiting an experienced Post‑Doc in Skeletal Muscle Molecular Physiology @nih-sport-sciences.bsky.social Oslo, Norway

Join our multi‑omics EMMA project on mitochondrial epigenetic memory in human muscle aging

4‑year position

Start May

Apply at Jobbnorge: www.jobbnorge.no/en/available...

Researchers insist….

Universität Basel: PhD position in systems biology (Zampieri Lab) The Department of Biomedicine is a joint effort between the University of Basel and the University Hospitals Basel. It unites basic and clinical scientists to advance our understanding of health and d...

The Zampieri Lab at the University of Basel is recruiting a highly motivated PhD candidate to investigate how metabolic programs drive cancer metastasis.
📩 Only applications submitted through the official recruiting system of the University of Basel will be considered.
jobs.unibas.ch/offene-stell...

To kickstart this new Bluesky account: We're hiring!
The Bertolin Lab @dundee.ac.uk is looking for a postdoc to work on DNA-end homeostasis & genome stability, funded by Wellcome Trust Award. Exciting science, fantastic environment, founding role in the lab.
Details in the flyer — get in touch! 👇

Histone variant H2A.Z mutant suppresses the senescence-associated secretory phenotype https://www.biorxiv.org/content/10.64898/2026.02.16.706244v1

De novo design of GPCR exoframe modulators - Nature De novo designed proteins that target the transmembrane domain of G-protein-coupled receptors, created using iterative structural predictions, are able to act as agonist-positive, negative or biased a...

De novo designed GPCR exoframe modulators restore the activity of various dopamine receptor loss of function mutants #NBThighlight www.nature.com/articles/s41...