Rosana Collepardo

A vision of chromosome organization Cryogenic electron tomography of condensed chromatin enables multiscale analysis of its structure

Cryogenic electron tomography of condensed chromatin enables multiscale analysis of its structure.

Learn more in a new #SciencePerspective: https://scim.ag/3Yfn1T3

Want to learn about how we use computational approaches at different scales to study biomolecular condensates?
Check out our latest review, out in Advances in Physics X
@juliamaristany.bsky.social @alinaemelianova.bsky.social
@rcollepardo.bsky.social

www.tandfonline.com/doi/epdf/10....

Huge congratulations, Daniel!!

Our Science paper is out!

Huge congratulations to @huabin-zhou.bsky.social, Mike Rosen, and the brilliant @janhuemar.bsky.social @juliamaristany.bsky.social and @kieran-russell.bsky.social from our group

News: bit.ly/4avnkAr and bit.ly/3XBGVHS

Great perspective by @vram142.bsky.social +K Zhang

An electrostatic repulsion model of centromere organisation During cell division, chromosomes reorganise into compact bodies in which centromeres localise precisely at the chromatin surface[1][1]–[4][2] to enable kinetochore-microtubule interactions essential ...

These ones yes, as they are single component and the fibers are regular. But they can be heterogeneous too, one of many possible examples here: www.biorxiv.org/content/10.1...

Thank you♥️♥️♥️

In collaboration also with @huabin-zhou.bsky.social, Jorge R Espinosa and David Farré-Gil

with contributions from super talented @yifangccc.bsky.social @juliamaristany.bsky.social @janhuemar.bsky.social and @nachper.bsky.social from our group

Very excited to present OpenCGChromatin🔥🔥🔥

A new coarse-grained model that probes full chromatin condensates at near-atomistic resolution to reveal the molecular regulation of chromatin structure and phase separation

Brilliantly led by @kieran-russell.bsky.social, with the Rosen and Orozco groups

Many thanks to @jojdavies.bsky.social for inviting us to take part in this exciting study, combining MCC ultra with simulations to explore how the biophysical properties of chromatin govern its structure in living cells.

Simulations by @janhuemar.bsky.social and @juliamaristany.bsky.social

Check out our new work, led by talented @janhuemar.bsky.social, where we uncover that pioneer factor Oct4 remodels chromatin for DNA access not by opening it but by exploiting nucleosome breathing and forming clusters 🔥🔥🔥

We found that charge asymmetry along chromatin drives centromeres to the chromosome surface during cell division 🔥🔥🔥

If you want to know more, check our latest work in collaboration with the labs of Daniel Gerlich, Mike Rosen, and Sy Redding

Simulations by superstar @juliamaristany.bsky.social

It was a huge treat for me personally, and the Chemistry Department more generally, to host you. Thank you for examining Pin Yu, and the inspiring talk and discussions ⭐️⭐️⭐️⭐️⭐️

So excited to finally see our CTPR-condensate work published! Well done Chris, Mateo, Julia et al. ❤️ @chemicalscience.rsc.org @phar.cam.ac.uk @rcollepardo.bsky.social @juliamaristany.bsky.social
doi.org/10.1039/D5SC...

In this wonderful collaboration with K Maeshima and M Shimazoe we show that H1 in living cells acts as a liquid-like glue not a driver of stiff zigzag fibers 🔥🔥🔥 Each H1 bridges multiple nucleosomes and exchanges nucleosomes frequently: boosting both compaction and dynamical behaviour of chromatin

Looks amazing!! Congratulations 🔥🔥🔥

We are excited to announce a new faculty position here in Cambridge, for researchers in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Come and join us! Happy to answer questions about research, teaching and working here. www.jobs.cam.ac.uk/job/50414/

To close, we have Jan Huertas from Cambridge University @janhuemar.bsky.social presenting our work in collaboration with the Rosen lab on the structure of chromatin inside condensates and the role of histone tails #BPS2025 @mgo-bps.bsky.social

María Aristizabal from Queen’s University in Canada tells us how combining experiments and simulations informs on why histone modifications are involved in cancer #BPS2025 @mgo-bps.bsky.social

Shoji Takada from Kyoto University in Japan describes his impressive multiscale simulations of transcription regulation #BPS2025 @mgo-bps.bsky.social

Serena Sanulli from Stanford University @serenasanulli.bsky.social discusses HP1 condensates and chromatin structure #BPS2025 @mgo-bps.bsky.social

Now is the turn of Paul Meneses from Taekjip Ha lab at Johns Hopkins and Harvard Medical School discussing single molecule measurements on native chromatin #BPS2025 @mgo-bps.bsky.social

Rob McGinty from University of North Carolina discusses structural mechanisms of nucleosome demethylation #BPS2025 @mgo-bps.bsky.social

Now we have Marcus Woodworth from University if Pennsylvania telling us about chromatin states in native chromatin visualised with expansion microscopy #BPS2025 @mgo-bps.bsky.social

First is Michael Poirier from Ohio State, discussing the pathways by which H1 loads into nucleosomes #BPS2025 @mgo-bps.bsky.social

Starting now #BPS2025 @mgo-bps.bsky.social

Do you like chromatin, condensates, single-molecule imaging? Then you’ll love our #BPS2025 MGO symposium.

TODAY at 1:30 pm

Disrupting droplets Mutations in certain protein regions have predictable effects on the stability of cellular droplets and the risk of harmful protein clumps forming inside them.

Proud to have the final version of our paper on mutations + condensates + scaling laws published in @elife.bsky.social! Work led by @juliamaristany.bsky.social w/ @rcollepardo.bsky.social ! Read the digest here: elifesciences.org/digests/9906...

Are you in #BPS2025?

Come to join us at the MGO Symposium this afternoon!