Rosana Collepardo

We found that charge asymmetry along chromatin drives centromeres to the chromosome surface during cell division 🔥🔥🔥

If you want to know more, check our latest work in collaboration with the labs of Daniel Gerlich, Mike Rosen, and Sy Redding

Simulations by superstar @juliamaristany.bsky.social

It was a huge treat for me personally, and the Chemistry Department more generally, to host you. Thank you for examining Pin Yu, and the inspiring talk and discussions ⭐️⭐️⭐️⭐️⭐️

So excited to finally see our CTPR-condensate work published! Well done Chris, Mateo, Julia et al. ❤️ @chemicalscience.rsc.org @phar.cam.ac.uk @rcollepardo.bsky.social @juliamaristany.bsky.social
doi.org/10.1039/D5SC...

In this wonderful collaboration with K Maeshima and M Shimazoe we show that H1 in living cells acts as a liquid-like glue not a driver of stiff zigzag fibers 🔥🔥🔥 Each H1 bridges multiple nucleosomes and exchanges nucleosomes frequently: boosting both compaction and dynamical behaviour of chromatin

Looks amazing!! Congratulations 🔥🔥🔥

We are excited to announce a new faculty position here in Cambridge, for researchers in computational and/or theoretical biology, based jointly in Genetics and Mathematics. Come and join us! Happy to answer questions about research, teaching and working here. www.jobs.cam.ac.uk/job/50414/

To close, we have Jan Huertas from Cambridge University @janhuemar.bsky.social presenting our work in collaboration with the Rosen lab on the structure of chromatin inside condensates and the role of histone tails #BPS2025 @mgo-bps.bsky.social

María Aristizabal from Queen’s University in Canada tells us how combining experiments and simulations informs on why histone modifications are involved in cancer #BPS2025 @mgo-bps.bsky.social

Shoji Takada from Kyoto University in Japan describes his impressive multiscale simulations of transcription regulation #BPS2025 @mgo-bps.bsky.social

Serena Sanulli from Stanford University @serenasanulli.bsky.social discusses HP1 condensates and chromatin structure #BPS2025 @mgo-bps.bsky.social

Now is the turn of Paul Meneses from Taekjip Ha lab at Johns Hopkins and Harvard Medical School discussing single molecule measurements on native chromatin #BPS2025 @mgo-bps.bsky.social

Rob McGinty from University of North Carolina discusses structural mechanisms of nucleosome demethylation #BPS2025 @mgo-bps.bsky.social

Now we have Marcus Woodworth from University if Pennsylvania telling us about chromatin states in native chromatin visualised with expansion microscopy #BPS2025 @mgo-bps.bsky.social

First is Michael Poirier from Ohio State, discussing the pathways by which H1 loads into nucleosomes #BPS2025 @mgo-bps.bsky.social

Starting now #BPS2025 @mgo-bps.bsky.social

Do you like chromatin, condensates, single-molecule imaging? Then you’ll love our #BPS2025 MGO symposium.

TODAY at 1:30 pm

Disrupting droplets Mutations in certain protein regions have predictable effects on the stability of cellular droplets and the risk of harmful protein clumps forming inside them.

Proud to have the final version of our paper on mutations + condensates + scaling laws published in @elife.bsky.social! Work led by @juliamaristany.bsky.social w/ @rcollepardo.bsky.social ! Read the digest here: elifesciences.org/digests/9906...

Are you in #BPS2025?

Come to join us at the MGO Symposium this afternoon!

Thanks to the support of HECBIOSIM for enabling all our simulations www.hecbiosim.ac.uk 🙌🙌🙌

Chemically Informed Coarse-Graining of Electrostatic Forces in Charge-Rich Biomolecular Condensates Biomolecular condensates composed of highly charged biomolecules, such as DNA, RNA, chromatin, and nucleic-acid binding proteins, are ubiquitous in the cell nucleus. The biophysical properties of thes...

Introducing Mpipi-Recharged🔥🔥🔥

Our Mpipi coarse-grained model for biomolecular condensates now includes a pair-specific electrostatic potential that improves its predictions, including for challenging charged systems—all while still treating solvent and ions implicitly

pubs.acs.org/doi/10.1021/...

Who's going to #BPS2025?

Please join us at the MGO Symposium @mgo-bps.bsky.social on Saturday 1:30 pm Room 511ABC

Featuring experiments, simulations, and all the scales by
@serenasanulli.bsky.social @melikel.bsky.social
@maristizabal.bsky.social @janhuemar.bsky.social and more

Please repost! 🚀✨

It should've been #BPS2025

Don't miss these two super exciting talks on chromatin tomorrow at 5pm UK time!

Zoom link below

This is part of the Multiscale Genome Organisation subgroup of the 2025 Biophysical Society Meeting (BPS)

📢 Join us! We are recruiting an Associate Professor/Professor of Molecular and Cellular Biology to join our innovative research community!

Find out more about the position and apply: https://buff.ly/4iYDBjv

we are recruiting a postdoc to work on a collaborative project with the lab of Nynke Dekker in Oxford @nynkedekkerlab.bsky.social. Please RT www.hubrecht.eu/job/postdoc-...

We’re hiring! 🚨

We’re looking for motivated postdocs to join our team and help us advance the frontiers of chromatin simulations

Learn more and apply here: www.jobs.cam.ac.uk/job/50052/

Women and underrepresented profiles in STEM are encouraged to apply

Please repost to help us spread the word!

These large-scale simulations were only possible thanks to the incredible continuous support of HECBIOSIM www.hecbiosim.ac.uk ⭐⭐⭐⭐⭐

New super-efficient multiscale chromatin model by @kieran-russell.bsky.social

Thanks ⭐