Tom Lau

Job alert! Looking for a mass spectrometry expert to come join our team. Please share and let me know if you have any personal recommendations. #teammassspec www.linkedin.com/jobs/view/43...

Can't say i'm not a little tempted to try to come home :) I'll be back at the dept for the 20 year reunion at Xmas at least!

Silly take for a vacation day. Those couples that are smiling while sharing a slice and a hot dog at Costco, you just know they're gonna be together forever.

@thewoolab.bsky.social @brianliau.bsky.social @milkakostic.bsky.social @liron1bar-peled.bsky.social @katherinedonovan.bsky.social @danetteldaniels.bsky.social @craftycarbene.bsky.social @laurakiessling.bsky.social @piefuchs.bsky.social @doc-jlmeier.bsky.social @amandalsmythers.bsky.social

ChemBio in the PUB 2025 Chemical Biology in the PUB

Chembio in the Pub! The tastier, chattier version of the popular Boston conference. Jun 12th is pretty close to the GRC too so whether you're a local or visiting it would be great to hang out www.eventbrite.com/e/chembio-in... #chembio #chemicalbiology #bostonbiotech

The One Book That Explains Our Current Era Was Written 40 Years Ago NYT pundits and NBA coaches alike can't stop recommending this four-decade-old book.

#NeilPostman #Trump #MAGA #Musk #ElonMusk #Project2025 #TheFourthReich #BadFaith #Fascism archive.is/6TBfY

Still Amusing Ourselves
Why does this 40-year-old book by a career academic still hit so hard?

⏬ Bluesky 'bite-sized' article thread (12 min) with added links 📖🍿🔊

Paddy, Not Patty | For The Love Of Saint Patrick, Stop Calling It St. Patty's Day Listen here: It's Paddy's Day, not Patty's Day. A friendly guide to properly abbreviating St. Patrick's Day, because your Irish friends are tired of crying into their pints.

paddynotpatty.com

Gotta ridewithgps or Strava route?

Multi-locus CRISPRi targeting with a single truncated guide RNA - Nature Communications A critical goal in functional genomics is evaluating which non-coding elements contribute to gene expression, cellular function, and disease. Here the authors present a CRISPRi-based method using trun...

Truncated gRNA sequences to target Cas9 fusions to hundreds of sites with similar sequences: www.nature.com/articles/s41...

This should address a question I commonly get for GLoPro (PMID: 29735997), about targeting TF binding sites throughout the genome, rather than a single locus.

Cool work.

@kusterlab.bsky.social Still happening, is it just me?

Whom would you like to hear at our next event?

The planning for the 5th Virtual ChemBioTalks is starting. We are excited for talks by @oconnorlab.bsky.social, @craigmcrews.bsky.social and Kelly Chibale.

Let us know in reply to this post, whom you would additionally like to hear!

Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets - Nature Communications Autophagosome tethering compounds (ATTECs) are small molecule degraders hijacking the autophagy system. Here, the authors show that current ATTEC ligands did not bind to their designated targets but e...

There are no shortcuts in drug discovery. And it takes incredible efforts to make sense of what you can find in the scientific literature. This is an excellent piece of work to quality check what has been claimed as a new avenue in targeted protein degradation (TPD). www.nature.com/articles/s41...

Thoughts for the future Nature Chemical Biology - As Nature Chemical Biology approaches its third decade we asked a collection of chemical biologists, “What do you think are the most exciting frontiers or the most...

We asked a collection of chemical biologists, “What do you think are the most exciting frontiers or the most needed developments in your main field of research?”

You can read that they said in our Feature “Thoughts for the future” – Free to read in January. rdcu.be/d5Ksw

Turns out the best seat on the plane is the one not next to your own family!

Ogdenville vibes

1/ In two back-to-back papers, we present our de novo TRACeR platform for targeting MHC-I and MHC-II antigens

TRACeR for MHC-I: go.nature.com/4gcLzn5
TRACeR for MHC-II: go.nature.com/4gj5OQk

Come with me as I troubleshoot this very high GC PCR toward clonable homology arms in an actinobacteria. Testing DMSO, Betaine 1M, and Propylene Glycol to see if we get amplification. Arms are 1000bp. Full length with arms and gene is 2800bp. Let's go!

🧵 1/n

This was glorious. I will never complain about a 2 hour toddler flight to Detroit ever again.

Very neat system from Alice's team. I love the name too!

Link?

Molecular and genetic characterization of sex-linked orange coat color in the domestic cat The Sex-linked orange mutation in domestic cats causes variegated patches of reddish/yellow hair and is a defining signature of random X-inactivation in female tortoiseshell and calico cats. Unlike th...

Fellow Genetics professors - rejoice! This is pedagogy heaven: the paradigmatic epiallele in calico cats … is built on a cis-regulatory deletion, not a coding mutation!
We can teach it all off 1 paper!
1. Woo
2. Hoooo!!!
H/t @lianafaye.bsky.social

www.biorxiv.org/content/10.1...

Delighted these fun explainers have made it to bluesky

The Chemical Probes Portal – 2024: update on this public resource to support best-practice selection and use of small molecules in biomedical research Abstract. The Chemical Probes Portal (www.chemicalprobes.org) is a free, public resource, based on expert-reviews, that supports the assessment, selection

Assume all small molecules are unselective for their protein target until proven otherwise. Even if the vendor tells you it’s a selective inhibitor for X, there’s a decent chance it isn’t selective! So how do we find quality molecules for scientific experiments? academic.oup.com/nar/advance-...

Large-scale characterization of drug mechanism of action using proteome-wide thermal shift assays An approachable framework for the scalable implementation of proteome-wide thermal shift assays to assess drug mechanisms of action.

Nice new large proteomics dataset on drug MoA applying proteome integral solubility alteration (PISA) from @dschweppe.bsky.social and Gygi lab #TeamMassSpec

Article: doi.org/10.7554/eLif...
Blog post by @dereklowe.bsky.social: www.science.org/content/blog...

Is ProteomicsDb dead? Even a single protein search just infinitely loads for me

Chemical biologists with proximal activity

In a wonderful intersection of my science and local policy bluesky worlds, Somerville City Councilor @benforward3.bsky.social created a better split-Gal4 system

Yes! My soccer analytics Twitter list was one of things keeping me from fully migrating, would love to see more folks here

Interesting @biorxivpreprint.bsky.social preprint by a team around Jason Thomas and Andrea Byrnes of Novartis. They developed a photoaffinity probe based on the RNA-splicing modulator branaplam for the transcriptome-wide identification of RNA binding events in native cells. doi.org/10.1101/2024...