David Peeler

Excited for #BMES2025! Come find me at poster U41 on Thursday 10-11am/3:30-4:30pm to hear about our recent work or swing by the UO/OSU booth to learn about our opportunities through our PhD program and faculty search @uoknightcampus.bsky.social

This post has now been filled but I always welcome fellowship applications and look forward to future hiring opportunities!

Intranasal delivery of mRNA expressing newly identified Acinetobacter baumannii antigens protects against bacterial lung disease - npj Vaccines npj Vaccines - Intranasal delivery of mRNA expressing newly identified Acinetobacter baumannii antigens protects against bacterial lung disease

Just to flag some papers from the lab
First up - we identified novel antigens from Acinetobacter baumannii and demonstrated greater protection when delivered intranasally
www.nature.com/articles/s41...

Just touched down in Philly for #CRS2025! Come hear about STING-adjuvanted saRNA on Wednesday and chat to me any time about openings in my lab -- looking forward to an inspiring week :)

Please do share and drop me a note about any all-star candidates you might know!

Beginning in January 2026, my lab will study interfaces in drug delivery between nanomaterial chemistry and innate immunology -- candidates from both disciplines are encouraged to apply.

Check out our building on @uoknightcampus.bsky.social !
knightcampus.uoregon.edu/building-2

I'm on the [🦆] hunt for an immunoengineering postdoc to join my growing lab as we launch in the Department of Bioengineering at the University of Oregon!
careers.uoregon.edu/en-us/job/53...

www.mdpi.com/2076-393X/13...
Great to see the first steps in utilising saRNA vaccines in Africa led by an African team

Baby Is Healed With World’s First Personalized Gene-Editing Treatment

Huge news for next generation nucleic acid medicines!! Maybe we should keep funding them?

Baby Is Healed With World’s First Personalized Gene-Editing Treatment www.nytimes.com/2025/05/15/h...

headshots of Dr. Sara Keller and Dr. David Peeler

We are very excited to welcome Dr. Sara Keller (@sarabkeller.bsky.social) and Dr. David Peeler (@djpeeler.bsky.social) to the Department of Bioengineering. Both will launch their labs in early 2026.

My allstar wife @sarabkeller.bsky.social will also be opening a therapeutic ultrasound group in the same department :) We can't wait to link up with the immunology, drug delivery, and acoustics communities in Oregon and across the States after ~5 years away. For now--stay tuned for more!

My linkedin post has the key details
www.linkedin.com/posts/djpeel... but you can also read about the lab's focus on nucleic acid delivery-driven vaccines and immunotherapies at my website: www.davidpeeler.com

I'm thrilled to announce that I'm launching the Biomaterial Research for Immunomodulation, Drug delivery, and Genetic Engineering (BRIDGE) lab in January 2026 as an Assistant Professor in the Department of Bioengineering at the University of Oregon! @uoknightcampus.bsky.social

@cerenkutahya.bsky.social @rifaiegrahamlab.bsky.social @prof-tregoning.bsky.social

The Bill & Melinda Gates Foundation funding for this hugely collaborative project brought together polymer chemistry and microfabrication expertise in the Stevens group with the immunology insight of the @robinshattock.bsky.social group, most of whom are not on Bluesky (yet)!

We found that SCRIBE-mediated sustained OVA release profiles correlated with higher antibody titers and subtype class switching. By delivering model vaccine boosters with delayed first order kinetics, we induced equivalent titers to those of a double injection formulation.

Inspired by the osmotic pump, the porthole in our hollow microparticle allowed for a precise investigation of how resin thickness and chemistry control protein release kinetics. We were also able to maximize injectability with spherical designs that are inaccessible to other microfab strategies.

To the best of our knowledge, we achieved the highest resolution printing with PLGA yet (500 nm XY, 1 μm Z) with printing error < 150 nm. The key breakthrough for me was realizing that we could blend various comonomers with the PLGA-TA to tune the print properties without compromising resolution.

We introduce a new family of PLGA-based resins for two-photon polymerization (2PP) 3D printing, Spatiotemporal Controlled Release Inks of Biocompatible polyEsters (SCRIBE), and show how top-down microparticle design can tune immune responses to model subunit vaccines.

Nanoscale Biodegradable Printing for Designed Tuneability of Vaccine Delivery Kinetics Spatiotemporal Controlled Release Inks of Biocompatible polyEsters (SCRIBE) is a novel 2PP resin family with sub-micron resolution and tuneable hydrolysis. SCRIBE enables direct printing of hollow mi...

Our article "Nanoscale Biodegradable Printing for Designed Tuneability of Vaccine Delivery Kinetics" is open-access at Advanced Materials!
advanced.onlinelibrary.wiley.com/doi/10.1002/...

Major shout to my co-first author Rujie Sun and all our wonderful collaborators who helped realize this dream!

Would love to join!