Xi-Han Zhang

Congratulations!!!

🧩New study: "Network Constraints on 𝘪𝘯 𝘷𝘪𝘷𝘰 Synaptic Alterations in Schizophrenia"

medrxiv.org/content/10.1...

We map a prominent brain-wide pattern of synaptic defects in people with Schizophrenia using PET, then model the molecular, cellular & connectomic features shaping this pattern 🧵1/3👇

The molecular and cellular underpinnings of human brain lateralization Hemispheric specialization is a fundamental characteristic of human brain organization, where most individuals exhibit left-hemisphere dominance for language and right-hemisphere dominance for visuosp...

🚨 New #preprint: The molecular and cellular underpinnings of human brain lateralization

🔗 doi.org/10.1101/2025...

🧠 We identify an acetylcholine-norepinephrine axis underlying functional lateralization, along with mitochondrial and cellular correlates. 🧵1/9👇

#neuroskyence

I'm a huge fan of surfplot now!

Converging cortical axes - Nature Neuroscience The cerebral cortex shows complex organization across diverse biological scales, from regional chemical and cellular specializations to macroscale functional networks. Zhang et al. report that macrosc...

6/6 Wondering what this means for the field? Review article by
@bogglerapture.bsky.social and @konradwagstyl.bsky.social discusses how my paper adds to converging evidence for the organization of the cortex along the sensory-association axis.
www.nature.com/articles/s41...

5/6 Functional network assignment can be predicted by cell-type abundances in post-mortem tissue. Motor, visual, and limbic networks, ventral attention/salient networks can be well-predicted. Default, frontoparietal/control, and dorsal attention networks are easier to be predicted as each other.

4/6: Large-scale networks possess distinct cellular profiles, hinting at computing motifs for specialized functions. For example, dorsal attention network is enriched by layer 2/3 and layer 5 ITs, whereas ventral attention/salient network is enriched by layer 6 neurons.

3/6: Multivariate cellular profiles track the functional gradient architecture of cortex. Permutational canonical correlation analysis, reveals linear combinations of cell type distributions that maximally correlate to each functional gradient.

2/6: Univariate cell type distributions align with gradient topographies: SNCG and SST interneurons and excitatory L5 IT are preferably localized at transmodal, and the L4 IT at the unimodal end. Cell types are imputed from gene expression in bulk tissue samples and single-nucleus data.

1/6: Here, we examine associations between the spatial abundance of cell-types with functional gradients and networks across the cortical sheet.

w/ @avramholmes.bsky.social @sidchop.bsky.social @elvisha.bsky.social KevinAnderson, Hao-Ming Dong, Prashant Emani, Mark Gerstein, Daniel Margulies.

The cell-type underpinnings of the human functional cortical connectome - Nature Neuroscience Here Zhang et al. establish multiscale relationships that link postmortem cell-type distributions with the in vivo functional organization of the human cerebral cortex, as assessed through functional ...

Excited to share my work revealing that functional organization of human cortex is reflected in the spatial variability of different cell types!
nature.com/articles/s41...
PDF rdcu.be/d0ZAc

Thank you!!

Thank you for writing such great views for our work!

Converging cortical axes - Nature Neuroscience The cerebral cortex shows complex organization across diverse biological scales, from regional chemical and cellular specializations to macroscale functional networks. Zhang et al. report that macrosc...

Had a lot of fun writing this news & views article on Converging Cortical Axes with @bogglerapture.bsky.social
shorturl.at/LsB5p

The cell-type underpinnings of the human functional cortical connectome - Nature Neuroscience Here Zhang et al. establish multiscale relationships that link postmortem cell-type distributions with the in vivo functional organization of the human cerebral cortex, as assessed through functional ...

Latest work led by Xihan Zhang looking at the cell-type underpinnings of the human functional cortical connectome is out now in Nature Neuro! 🧠

www.nature.com/articles/s41...