Matthew Hackling

Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity Obesity is a major disease risk factor due to obesity-associated hyperinflammation. We found that obesity induced Nod-like receptor pyrin domain–containing 3 (NLRP3) inflammasome hyperactivation and e...

#NatMetabPicks | In @science.org led by @zhenyuzhong.bsky.social (UT Southwestern)

Obesity rewires nucleotide metabolism in macrophages which leads to inflammasome hyperactivation.

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www.science.org/doi/10.1126/...

Not many people realise that Islam Judaism and Christianity are all monotheistic abrahamic religions from the same geography (they worship the same god in similar ways with prayer and fasting, recognise Jesus as a historical figure, have same holy figures and have the same core ethical rules)

Arguments to begin in landmark social media addiction trial set in Los Angeles The world’s biggest social media companies face several landmark trials this year that seek to hold them responsible for harms to children who use their platforms.

“Borrowing heavily from the behavioral and neurobiological techniques used by slot machines and exploited by the cigarette industry, Defendants deliberately embedded in their products an array of design features aimed at maximizing youth engagement to drive advertising revenue,” the lawsuit says.

woodyguthrie.org/Lyrics/This_...

Screenshot of Elon Musk post on Ex: “Elon Musk y X @elonmusk For those unaware, Space has already shifted focus to building a self-growing city on the Moon, as we can potentially achieve that in less than 10 years, whereas Mars would take 20+ years. The mission of SpaceX remains the same: extend consciousness and life as we know it to the stars. It is only possible to travel to Mars when the planets align every 26 months (six month trip time), whereas we can launch to the Moon every 10 days (2 day trip time). This means we can iterate much faster to complete a Moon city than a Mars city. That said, SpaceX will also strive to build a Mars city and begin doing so in about 5 to 7 years, but the overriding priority is securing the future of civilization and the Moon is faster.”

BREAKING: “in my 24th year of my quest to settle the planet Mars, I have just been informed of a basic fact of celestial mechanics.”

Sea and subsea military Autonomous vehicles

The most horrible revelation from the trump presidency is that there is a massive white supremacist voting bloc out there in the USA. You have to make voting mandatory to bring some sense to your country.

why we stop making computers look fresh

Saw a video of Ukrainians trying to evacuate some grandmas under attack from Russian FPV drones one flew into the front of the van and blew up and they shot down another with a rifle of some sort as it was hunting them. Dystopian.

So uh Ring just up and said they've got a huge centralized private surveillance network they can leverage all at once huh

Bad Bunny holds a football that says Together, we are America.

Unidos somos América.

That art on the wall is amazing btw

Bad Bunny’s closing messages during his Super Bowl performance:

“The only thing more powerful than hate is love”
“Together, we are America”

BREAKING: A statement announcing Jeffrey Epstein's death has been found in the recent Epstein files, but it's dated a day before he killed himself in his cell, per the DM

accidentally took a photo and it whatevered it

BREAKING: Representative Massie says he will start reading Epstein’s client names publicly if Pam Bondi’s Department of Justice does not release them.

So in a clumsy way I can talk to my Mac now and it does stuff #openclaw on #rabbitr1

So my rabbitr1 now does openclaw somehow with a web browser ?

Wow the mainstream media isn’t spinning this one for a change

I think car door handles should still work when the car is on fire

🤘

They looked for “Don T” in the Epstein files and redacted all instances, which means they also redacted a lot of “don’t”

Without naming your job, tell me something you say over and over again at work.

"We should reduce the blast radius."

will usa be able to build a rare earth supply chain before they run out of components for TLAMs? time will tell.

Donald Trump Jr, who has exactly zero experience or competence in manufacturing or defense, has received more than $600,000,000 in contracts from Pete Hegseth's "Department of War."

Enjoying a nice distraction with starfleet academy - some post scarcity liberal democratic socialism with civil rights is refreshing

epic handshake meme. left arm: infosec. right arm: musical theatre. handshake: we're gonna need a key change

No one tells you about all the meetings and follow up email chains where you are just trying to help people understand/describe/properly document the craziness they are trying to do and politely try and influence them to do the common sense things and help them execute