Daniel Graham

Thanks Jonathan, that means a lot to me.

03.04.2025 22:26 — 👍 0    🔁 0    💬 0    📌 0

🙏 (Finally, the perfect use of that emoji)

03.04.2025 22:24 — 👍 1    🔁 0    💬 0    📌 0

Indeed. Biology is merciless to our strengths and weaknesses.

03.04.2025 21:29 — 👍 1    🔁 0    💬 0    📌 0

Dx: PD chordoma w/ SMARCB1 loss. I felt so bad I offered to see the patient to apologize but my ortho onc wouldn’t let me lol. Did CK on bx and sure enough, little histiocytoid fragments w/ TINs +. I was humbled, big time. It still haunts me yrs later as I put chordoma in the ddx when I shouldn’t

20.03.2025 05:49 — 👍 2    🔁 0    💬 4    📌 0

Knee replacement done. Low power. had melting wax look peripherally, w/sheets and large islands of histiocytoid cells with tt necrosis & TINs. CK, EMA +, S100 -, INI1 loss. I called ES. Sent to you guys. Judith emails me it’s brachyury + and my head is spinning.

20.03.2025 05:49 — 👍 1    🔁 0    💬 1    📌 0

Thanks for bringing up. One of my cases was in that paper. I failed twice. Pt was 60s F. Initially, was clinically portrayed as knee TGCT w/ bone erosion. Bx showed synovitis w/ heme, mixed inflam, foam cells and small bits of what looked like histiocytes a/w neuts. I called TGCT.

20.03.2025 05:49 — 👍 1    🔁 0    💬 1    📌 0

TTF1

#PathSky 84M with lung nodule, signed out as “adenocarcinoma, favor pulmonary origin”. There is supposed to be a bit of TTF1 expression, but it is subtle to say the least.

18.03.2025 18:40 — 👍 14    🔁 8    💬 1    📌 0

I was excited to add ‘modulated’ to my descriptors repertoire 😅

08.03.2025 02:47 — 👍 1    🔁 0    💬 0    📌 0

But what if you miss a cool looking neutrophil on slide 133? Can’t let that happen 😂

07.03.2025 23:01 — 👍 0    🔁 0    💬 0    📌 0

What a saga, I love it!

07.03.2025 22:32 — 👍 0    🔁 0    💬 0    📌 0

Very good to know, thank you.

07.03.2025 21:34 — 👍 0    🔁 0    💬 0    📌 0

Tricky one!

07.03.2025 20:11 — 👍 0    🔁 0    💬 0    📌 0

Okay then, let’s look closer. That material is odd. Spherical ones remind me of tyrosine crystals a bit. The intervening cells are giant cells closely apposed to material, and non descript fibro/myofibro type cells. I’m thinking about pseudogout. Not sure if crystal morph matches though.

07.03.2025 07:37 — 👍 1    🔁 0    💬 1    📌 0

I’m with you, my mistakes are vivid. Some will never be forgotten.

07.03.2025 07:28 — 👍 0    🔁 0    💬 0    📌 0

Calcifying aponeurotic fibroma, schwannoma, pmt? Any stains?

07.03.2025 02:37 — 👍 0    🔁 0    💬 1    📌 0

Excellent case! Never seen one with that pattern

07.03.2025 02:32 — 👍 0    🔁 0    💬 1    📌 0

3rd image made me want STAT6. Then I got instant gratification! Great case, thank you.

14.01.2025 20:30 — 👍 3    🔁 0    💬 1    📌 0

Kal-sp, favor KA. P53, p16, ki67?

14.01.2025 20:27 — 👍 0    🔁 0    💬 2    📌 0

www.sciencedirect.com/science/arti...
Link to the paper that should help everyone diagnose keratoacanthoma with greater confidence.

14.01.2025 08:35 — 👍 12    🔁 4    💬 0    📌 0