Jonathan H

Happy New Year, Dr Carr!

3 weeks to go! There's still time to sign up!!

clevelandcliniclabs.com/register-now...

#pathsky

RAC3910 M60s. Dorsal foot warty lesion. ?VW ?SCC.#Dermpath @iyengarish.bsky.social

CREM is a regulatory checkpoint of CAR and IL-15 signalling in NK cells - Nature The transcription factor CREM is a pivotal regulator of NK cell function, making CREM a valuable target to increase the efficacy of anticancer immunotherapies based on this cell population and chimeri...

I’m thrilled to share our work out now in Nature identifying CREM as a central intracellular checkpoin in #CARNK cells.

📄Link: nature.com/articles/s41...

Our story👇🏼

Oh, I mean it looks very epithelioid, reminding me of those biphasic sarcomas that have epithelioid component

Almost like the epithelial component in a glandular MPNST or biphasic synovial sarcoma

International Melanocytic Slide Club associated with UK National Specialist Skin EQA
Questionaire & 10 Educational Cases: Thin melanocytic lesions.
Please take part & share w colleagues.
Respond by 26th May 2025
Meeting Discussion 2/6/2025
forms.cloud.microsoft/e/vceeXWXwLE...

YouTube video by Sanjay Mukhopadhyay Thoracic Pathology Unknown Slide Conference Feb 2019

youtu.be/4i1mnz889bo?...

YouTube video by Cleveland Clinic Lung Granulomas Caused by Fungal Infection

#pathsky

youtu.be/aRuH_GwPYyA?...

The veggie appears full of ❤️

Happy Friday #dermpath! 😆🔬

Two of our articles were selected as Editor’s Choices in this month’s AJDP — and one even landed the front cover, featuring this photogenic gene schematic! 🧬🎨🎉

#MDACCPath #molepath #pathology

Sclerosing extramedullary hematopoietic tumor in chronic myeloproliferative disorders - PubMed Sclerosing extramedullary hematopoietic tumor (SEMHT) occasionally may arise in patients with chronic myeloproliferative disorders (CMPDs). Morphologically, these tumors may be mistaken for sarcomas o...

He turned out to have myelodysplasia and myelofibrosis. This is a “sclerosing extramedullary hematopoietic tumor”, basically dysplastic EMH presenting as a soft tissue mass. pubmed.ncbi.nlm.nih.gov/10632487/

TP53 Wild-Type, Human Papillomavirus-Independent Anal Growth/(Intra)Epithelial Lesion (ANGEL): A Potential Precursor of Anal Squamous Cell Carcinoma - PubMed Human papillomavirus (HPV) underpins ∼90% of squamous cell carcinomas (SCCs) of the anus and perianal region. These tumors usually arise in association with precursor lesions such as anal intraepithel...

Counterpart of vulva's DEVIL. Amazed by the people making those acronyms.
pubmed.ncbi.nlm.nih.gov/39863109/

Differentiated SCC in background of lichen sclerosis. Hope it's p53 mutant or null type. Otherwise may fall into the category of "ANGEL"?

#PathSky Abdominal wall mall mass, 65M. Multinodular with thick fibrous septa. Bland spindled to ovoid cells surrounding prominent vessels. Microcystic, pseudoglandular spaces.

What prompted you to do S100/SOX10? History or else? I do see a few large nuclei without staining for b-cat

Dan, we all learn from our mistakes. I always admire your diagnostic skills across different subspecialties. Your courage to share your experience even further shows your character.

TTF1

#PathSky 84M with lung nodule, signed out as “adenocarcinoma, favor pulmonary origin”. There is supposed to be a bit of TTF1 expression, but it is subtle to say the least.

Keratin

S100

Brachyury

SMARCB1

IHC: positive for keratins, S100 protein, and brachyury. SMARCB1 retained (normal).

It does not look like a collision tumor since those phenotypically distinct cell types are mixed with each other. Lots of people don't believe basosquamous cell carcinoma. This tumor also has convincing glandular differentiation. It will be interesting to see the molecular findings of this tumor.

Sebaceous carcinoma is on the differential as well

Although well-circumscribed, worrisome for malignancy. It has different cell populations, maybe a hidradenocarcinoma?

Would have definitely thought this was schwannoma

Another unvaccinated child dies from measles, a fully preventable disease, and only the second child to die from measles in the US in the past 22 years

More like anal area with hemorrhoidal component ...

Seems to be legitimate for squamoid eccrine duct carcinoma

The MAHA Movement’s Trivialization of Measles The outbreak of disease in Texas is, in fact, unusual.

RFK Jr. and his movement do not simply ignore the need for vaccination. They also have a habit of dismissing child death and disability.

www.theatlantic.com/health/archi...

Maybe STAT6 or DDIT3 is also co-amplified. I would vote 12q13 as the most iconic chromosomal locus in soft tissue tumors

Mets?

RAC9197: This was a patient with Ferguson Smith disease (FSD). Consult case, had been reported as a SCC but on review I thought it was fairly typical for FSD epithelioma. Quite hard to find systematic studies of FSD histology but histo & behaviour is similar to keratoacanthoma it seems.