Cornelius Lee

Amazing example of influenza cheat/cooperator cycles in this recent paper - the repeatability of the oscillatory cycles is so striking

Congrats to @alnajifg.bsky.social , @christopherbrooke.bsky.social , @vignuzzilab.bsky.social & friends

www.biorxiv.org/content/10.1...

🧪 #socialviruses

Published version up at @natcomms.nature.com

New data with Aspergillus getting into tuberculous granulomas and growing like it's a member of the extended Myco family

doi.org/10.1038/s414...

Got tattooed! Spot the scientific elements! 🧬🪐

This week, my lab, and research institute A*IDL, and A*STAR signed an ideation agreement with Flagship Pioneering Biotech and one of their portfolio companies Apriori to develop self-amplifying RNA vaccines for pandemic Flu threats. (1/3)

Finally, it's up on bioRxiv! It's been a rewarding journey shaping this story. My deepest gratitude to @vignuzzilab.bsky.social and @christopherbrooke.bsky.social for their incredible support, and to the @mcbillinois.bsky.social & @astar-idlabs.bsky.social for enabling this research

Longitudinal analysis of influenza A virus deletion-containing viral genomes reveals key determinants of co-evolutionary dynamics and interference The substantial genetic diversity generated during influenza A virus replication facilitates both evasion of pre-existing host immunity and cross-species emergence. A major contributor to this diversi...

First big piece of research from our SG lab: Fadi's work with Chris Brooke's lab. Flu serially passaged 80X selects a defective genome with improved competition, but is nonviable as a full virus!
Notable improvement & safety for DVGs as antiviral RNA therapies!
www.biorxiv.org/content/10.1...

High-throughput single-virion DNA-PAINT reveals structural diversity, cooperativity, and flexibility during selective packaging in influenza Abstract. Influenza A, a negative-sense RNA virus, has a genome that consists of eight single-stranded RNA segments. Influenza co-infections can result in

Our work on influenza genome packaging using high-throughput single-virion DNA-PAINT is out in NAR! Packaging appears structurally diverse and flexible. Big thanks to Christoff & Qing (amazing effort)! A collab with @efodor.bsky.social, @nicolerobb.bsky.social academic.oup.com/nar/article/...

Officially starting my DPhil in Condensed Matter Physics with @achilleskap.bsky.social (@kavlioxford.bsky.social) and @efodor.bsky.social (@dunnschool.bsky.social)! A collaborative project to understand influenza dynamics. Excited to see where this project goes!

Hello Oxford!!

The displacement of the σ70 finger in initial transcription is highly heterogeneous and promoter-dependent Abstract. Most bacterial sigma factors (σ) contain a highly conserved structural module, the ‘σ-finger’, which forms a loop that protrudes towards the RNA

What controls how/when growing RNA unblocks the "door" to exit RNA polymerase? Brilliant duo Anna Wang and Abhishek Majumder led a study in my lab - now out in NAR - on this. *Sequence* matters a lot! Read on... Super smFRET/dynamics work as well. Excited! academic.oup.com/nar/article/...

Why does the m6A writer complex require so many proteins? Post-transcriptional gene regulation through m6A deposition is dysregulated in many diseases and is catalyzed by a multi-protein writer complex. This Unsolved Mystery investigates why the writer compl...

Post-transcriptional #GeneRegulation through #m6A deposition is dysregulated in many diseases. Samie Jaffrey &co investigate why the m6A writer complex requires multiple subunits and what roles its individual proteins might have in m6A regulation. 🧪
plos.io/3VjfjWI

Amused by cardiac muscle contraction differentiated from IPSCs ❤️ Super cool isn’t it?

Legend David Baltimore died yesterday. He understood the way things should work: "the real contribution of MIT is that it doesn't take itself too seriously. It takes ideas seriously, but the people are relatively informal. They are not self-aggrandizing the way academics can be."

Blood, sweat, and beers: investigating mosquito biting preferences amidst noise and intoxication in a cross-sectional cohort study at a large music festival Introduction We live in a world split between mosquito magnets and those lucky enough to remain (nearly) untouched. The reasons why some people attract more mosquito bites than others remain largely m...

Did I just read the best abstract ever? 😁

www.biorxiv.org/content/10.1...

Last day at @vignuzzilab.bsky.social ! Leaving in The Office style. Been a fruitful journey and definitely grew me scientifically🧬🔬!

What a dynamic team they make! This was the official send off for Cornelius heading to Oxford University for his PhD!

Found in my photo album. Beneath their family portrait, a boy looking at his younger brother. A quiet moment in the long legacy of Mount Sinai porters.

Happy Birthday Singapore 🇸🇬!

Late lab nights, vibing to RnB and beautiful DNA/RNA bands ✨

Thanks Marco!!!

Another life milestone! Goodbye National University of Singapore ! Been a good one ✨. Excited for the next phase of my life.

First ever poster presentation experience on influenza DVGs! Thanks to the amazing mentors @alnajifg.bsky.social and @vignuzzilab.bsky.social

Congratulations Cornelius, having completed his 1 year research attachment in my lab, this ASTAR Scholar heads out to Oxford University soon to PhD in the biophysics of influenza virus structure and assembly! 👏 👨‍🎓