✨Exciting to see clinical efficacy of peripheral #CB1R antagonism with #monlunabant. It will expand armamentarium for #obesity with an oral 💊therapy and a different mechanism than incretins ( #GLP1 #GIP)💉
⚡️Similar efficacies in all tested oral doses encourage testing lower doses to optimize safety.
09.10.2025 01:53 — 👍 0 🔁 0 💬 0 📌 0
🧵6️⃣ ⚡️Therapeutic modality to improve antifibrotic efficacy⚡️
📌 #Zevaquenabant treatment effectively reduces #fibrosis in human precision-cut lung slices (#hPCLS).
📌 Pulmonary delivery of zevaquenabant may offer a more targeted and safer #therapeutic modality for #fibrotic #lung #diseases
03.07.2025 18:20 — 👍 0 🔁 0 💬 0 📌 0
🧵5️⃣ ⚡️Therapeutic modality to improve antifibrotic efficacy⚡️
📌Systems #pharmacology reveals that #zevaquenabant and #nintedanib treatments reverse distinct and shared #pulmonaryfibrosis related pathways, provides opportunity for future clinical trials to improve clinical efficacy.
03.07.2025 18:20 — 👍 0 🔁 0 💬 1 📌 0
🧵4️⃣ ⚡️Therapeutic modality to improve antifibrotic efficacy⚡️
📌 #Zevaquenabant attenuates multiple #fibrosis-related pathways in lungs
📌 Pulmonary delivery of zevaquenabant attenuated #fibrogenic #macrophages expressing Spp1, Trem2, Tgfb1, Mertk, Fabp5, Cd9, Cd63, Gpnmb, Fabp4
03.07.2025 18:20 — 👍 0 🔁 0 💬 1 📌 0
🧵3️⃣ ⚡️Therapeutic modality to improve safety ⚡️
📌🫁Pulmonary delivery of #zevaquenabant (#MRI1867) by lowering the systemic dose 20-fold retains superior therapeutic efficacy in mitigating PF by eliminating systemic exposure in animal model of #PulmonaryFibrosis
03.07.2025 18:20 — 👍 1 🔁 0 💬 1 📌 0
🧵2️⃣ ⚡️Therapeutic target identification⚡️
📌 CB1R regulates #CD206-expressing macrophages and releases of #profibrotic mediators (IL-6, IL-4, LIF, GM-CSF, CXCL10, CCL7, CCL11, IGF-1).
📌 Inhibition of #CB1R in #AlveolarMacrophages attenuates #fibrogenic activation of Macrophages.
03.07.2025 18:20 — 👍 0 🔁 0 💬 1 📌 0
🧵1️⃣ ⚡️Therapeutic target identification ⚡️
📌 CB1R in #AlveolarMacrophages (AMs) is responsible to release #anandamide into #alveoli and to promote #fibrosis.
📌 CB1R in AMs plays a dominant role in pulmonary fibrosis by inducing fibrogenic macrophages.
03.07.2025 18:20 — 👍 0 🔁 0 💬 1 📌 0
📣Our work @jci-insight.bsky.social highlights the key role of #cannabinoid receptor 1 in #AlveolarMacrophages in promoting #PulmonaryFibrosis. We propose that pulmonary delivery of #zevaquanabant as an effective and safer therapeutic approach. Details in🧵👇https://insight.jci.org/articles/view/187967
03.07.2025 18:20 — 👍 0 🔁 0 💬 1 📌 0
‼️A post-doc position available in my lab at the NIH ‼️
⚡️Fibrosis Biology
⚡️Biomarker Discovery
⚡️Pharmacology
⚡️Therapeutic discovery
⚡️Translational research
See the position details👇
www.training.nih.gov/jobs/pdf-090...
#postdoc #medsky #Fibrosis
Please RT⚠️
01.07.2025 23:30 — 👍 3 🔁 3 💬 0 📌 0
Our research shows endocannabinoid anandamide in blood has biomarker functions in Hermansky-Pudlak syndrome. It not only captures early stage fibrosis progression in lung but also informs on therapeutic efficacy for CB1R antagonism.This may help to design effective anti-fibrotic therapy for #HPSPF
09.06.2025 23:06 — 👍 2 🔁 0 💬 0 📌 0
Cannabis and Cannabinoid Research is the premier peer-reviewed journal dedicated to the scientific, medical, and psychosocial exploration of clinical cannabis, cannabinoids, and the endocannabinoid system.
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