Martijn Selten

Very nice comic, as always!

Monika is such an amazing scientist. It has been such a privilege to see this story grow and develop during my time at @marinlab.bsky.social. I am so happy to see this finally out. Well done to all authors.

@martijnselten.bsky.social @clembrnrd.bsky.social

Haha, this is fantastic!

"Molecular switch” in the brain may explain why toddlers are uncoordinated New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London has established the molecular mechanism that drives interneurons in the cerebral cortex to mat...

New research has established the molecular mechanism that drives interneurons in the cerebral cortex to mature.

The work provides clarity how cortical circuits develop and on the mechanisms behind neurodevelopmental disorders.

Click to learn more👇

bit.ly/3THw7Gb

A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α partners with ERRγ and Mef2c to ...

1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social
@wellcometrust.bsky.social

A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α partners with ERRγ and Mef2c to ...

🚨 New Paper Alert! 🚨

I’m very happy to share our newest paper in Cell, led by the brilliant Monika Moissidis. We show that PGC1a regulates the maturation of PV+ interneurons in an activity-dependent manner.

Link below 👇
www.cell.com/cell/fulltex...

@cellpress.bsky.social @marinlab.bsky.social

Congratulations!!!

Distinct dendritic integration strategies control dynamics of inhibition in the neocortex Dendrites critically influence single-neuron computations, but their role in neocortical GABAergic interneurons (INs) remains poorly understood. We fo…

📣New study in Neuron, featuring modeling insights: "Cell-Specific Dendritic Integration in Cortical GABAergic Interneurons"! It reveals PV & SST interneurons compute differently. This highlights how distinct dendrites enable specialized brain computations!

www.sciencedirect.com/science/arti...

Poster with illustration of pregnant person dressed in green. Text reads: Vaccination in pregnancy, your voice matters: share your thoughts by completing our survey. Supported by Tommy's. Logo of King's College London on bottom right.

Dr. Katie Long is leading vital research, funded by an MRF award, to learn how pregnant people feel about vaccines during pregnancy. We want your views! Take this short survey: tinyurl.com/vaccines-in-...

For more information on vaccines in pregnancy visit tommys.org/vaccinations-pregnancy

Fos labels a distinct excitatory neuron ensemble for memory retrieval https://www.biorxiv.org/content/10.1101/2025.06.14.659414v1

A very nice read!

Molecular programs specifying properties and plasticity of parvalbumin interneuron innervation Parvalbumin-positive (PV) interneurons, a class of fast-spiking GABAergic interneurons, govern gain-control and the timing of neuronal signal propagat…

@scheiffelelab.bsky.social and I discussed the unique properties of synapses onto parvalbumin interneurons, the current knowledge & future aspects of the molecular mechanisms regulating these synaptic inputs: www.sciencedirect.com/science/arti...

Modular arrangement of synaptic and intrinsic homeostatic plasticity within visual cortical circuits | PNAS Neocortical circuits use synaptic and intrinsic forms of homeostatic plasticity to stabilize key features of network activity, but whether these di...

Very happy that this work is finally out in ‪@pnas.org‬! We show that synaptic and intrinsic forms of homeostatic plasticity sense distinct aspects of network activity, and can thus be independently recruited by distinct network functions. A thread:
www.pnas.org/doi/10.1073/...

1/6 Why does the brain maintain such precise excitatory-inhibitory balance?
Our new preprint explores a provocative idea: Small, targeted deviations from this balance may serve a purpose: to encode local error signals for learning.
www.biorxiv.org/content/10.1...
led by @jrbch.bsky.social

Cadherins orchestrate specific patterns of perisomatic inhibition onto distinct pyramidal cell populations Nature Communications - How cortical interneurons establish precise connections among intermingled populations of excitatory neurons remains unclear. Here, the authors reveal that Cadherins...

New paper from Julie Jézéquel and the Rico lab
on role of cadherins in neuronal inhibition out now in Nat Comms! @natureportfolio.nature.com rdcu.be/el18f

Fantastic work, congratulations!

Today I started recording these fantastic pyramidal neurons in layer 2/3 of the somatosensory cortex!

New collab with @igenescu.bsky.social.

Regulation of PV interneuron plasticity by neuropeptide-encoding genes - Nature Increasing the activity of individual parvalbumin-expressing interneurons in the mouse brain modulates the number and strength of inhibitory parvalbumin synapses received by these cells through changes in the expression of the neuropeptide-encoding genes Vgf and Scg2.

Nature research paper: Regulation of PV interneuron plasticity by neuropeptide-encoding genes.

https://go.nature.com/4lWkesG

Thank you Amélie!

Thanks Max!

Thanks Clem - It was great working on this together!

Thanks Fong!

🚨Paper Alert🚨 Our paper on the mechanism of homeostatic control in PV interneuron activity is now online in Nature! A massive thanks to all the authors, including @clembrnrd.bsky.social and @marinlab.bsky.social. Read the paper at www.nature.com/articles/s41....

I will soon start recruiting for a Wellcome-funded postdoc position! I’ll be at the #BNA2025 meeting next week. If you like cortical development, wiring, and post-transcriptional regulation, do get in touch and we can have a chat in Liverpool! 😀

Job alert 🚨 We are hiring a research assistant!

This 7-year position available @exeter.ac.uk from Sept 2025 will involve keeping the lab running as well as contributing to our research activities on brain development. Full details tinyurl.com/23nyds34.

Please spread the word!

Paper accepted!!!

Stay tuned for updates very soon!

(Now time for a little celebration)

Dynamic regulation of cortical interneuron wiring Inhibitory interneurons play crucial roles in modulating the circuits and activity patterns of the cerebral cortex. In particular, interneurons must a…

Our little update on the latest knowledge on interneuron wiring! www.sciencedirect.com/science/arti...

Congratulations Fong and team! Can't wait to read it!

Excited to share the latest work from our lab where we examined the role of pyramidal cells in regulating microglia development!

As per tradition here is a graphical summary of our paper in comic form.

www.science.org/doi/10.1126/...