🎲 Our paper on the genetics, energetics, and allostery in proteins with randomized cores and surfaces is out today @science.org!
🧬 By charting a protein’s sequence universe, we could rationalize which versions were kept through evolution – and why many stable ones were not.
25.07.2025 06:26 — 👍 30 🔁 12 💬 1 📌 1
“Nothing is less real than realism. Details are confusing. It is only by selection, by elimination, by emphasis, that we get at the real meaning of things.”
— Georgia O'Keeffe
28.06.2025 13:57 — 👍 1 🔁 0 💬 0 📌 0
On this day in 1954, the United States orchestrated a coup against Jacobo Árbenz, the progressive and democratically-elected leader of Guatemala, because he sought to restore land to small farmers and Indigenous communities that had been dispossessed by US fruit companies.
13.06.2025 10:32 — 👍 420 🔁 189 💬 9 📌 17
Massively parallel genetic perturbation suggests the energetic structure of an amyloid-β transition state
The aggregation rates of >140,000 mutants reveal the energetic structure of an amyloid-β nucleation reaction transition state.
Alzheimer’s disease 🧠starts with a molecular domino effect - but what triggers the first piece to fall?
In our new study we cracked open the black box of early protein aggregation, and the findings could reshape how we fight neurodegeneration. 🧵👇
www.science.org/doi/10.1126/...
12.06.2025 12:54 — 👍 11 🔁 4 💬 1 📌 1
“Scientists often study the past as obsessively as historians because few other professions depend so acutely on it. Every experiment is a conversation with a prior experiment, every new theory a refutation of the old.”
— Siddhartha Mukherjee, The Emperor of All Maladies
13.05.2025 20:34 — 👍 0 🔁 0 💬 0 📌 0
Any traders with inside information that Trump was going to walk back his tariffs — some of them, presumably, Trump family members and cronies — just made a fortune.
It all feels like chaos until you look more closely at who is winning.
09.04.2025 22:23 — 👍 7613 🔁 2109 💬 345 📌 105
In February 2025 we will be relocating to a new incubation space in the @www.pcb.ub.edu (surrounded by 3 research institutes and over 70 different companies). All positions are available for hybrid / fully remote options.
30.01.2025 14:43 — 👍 1 🔁 0 💬 0 📌 0
At ALLOX @alloxbio.bsky.social in Barcelona we now have 3 computational positions available!
📌Structural Bioinformatics Scientist 👉 tinyurl.com/3rs46j4t
📌Platform Bioinformatician 👉 tinyurl.com/nyvazbke
📌Computational Chemist 👉 tinyurl.com/5n6vpem3
Apply or repost to help us spread the word 🙏
30.01.2025 14:43 — 👍 23 🔁 21 💬 2 📌 2
Ph.D. student Landry Lab
gene duplication, cell signaling, protein evolution, full time member of the APOYG cult
Postdoc in Lehner lab @sangerinstitute | PhD @sangerinstitute @Cambridge_Uni | BSc @miptru 🇷🇺🇦🇲
Genomics | Synthetic Biology | Immunology | Reproduction
Emmy-losing Writer/Director (#Shrinking, @nbcSNL, @Netflix, @Hulu, @Dreamworks, @JimmyKimmelLive, #StrangePlanet, @NewYorker)
🔭🔬⚗️ Science Lover 📦🐈🧪⁉️
🍄Mycology and Infectious Diseases🦠
Research Engineer, PhD candidate 🧑🔬🧫🥼
ICVS, braga, Portugal 🇵🇹
Pasteur, Paris, France 🇫🇷
Sorbonne University, Paris, France 🇫🇷
Univ. François-Rabelais,Tours,France 🇫🇷
Computational structural biologist @Fox Chase Cancer Center. Gay, out & proud since 1986. I support transgender & nonbinary people. Living with CLL/SLL. Video about my LGBTQ+ life in science: https://tinyurl.com/45srzjdw. Views my own, not my employer's.
Modern Landscape Painter
JimMusil.com
The Earth BioGenome Project (EBP), a moonshot for biology, aims to sequence, catalog, and characterize the genomes of all of Earth's eukaryotic biodiversity over a period of ten years.
🌲Keep up with all EBP updates: https://linktr.ee/earthbiogenomeproject
Medicinal chemist / chemical biologist, author of “In the Pipeline” at http://science.org/blogs/pipeline. derekb.lowe@gmail.com and on Signal at Dblowe.18
All opinions are mine; I don’t speak for my employer in any way.
🧬 Structural Bioinformatics | 💊 AI/ML for Drug Discovery | Geometric DL
🔬 @iocbprague.bsky.social, prev. PhD @cusbg.bsky.social @mff.unikarlova.cuni.cz
Emeritus Prof (Imperial); Dir. of Strategy at RoRI. Former DORA Chair. Husband, father, carer. Also cares about science & equity. Personal a/c. Writes occasionally at http://occamstypewriter.org/scurry/. Proud Ballymena Professor
i’m a cartoon character
www.zezvaz.com/cartoons
animator | director | cartoonist
A group of student climate activists advocating for Fossil Fuel Non-Proliferation Treaty through non violent actions against EACOP project and climate injustices.
PhD student at @biozentrum.bsky.social. I prefer protein interactions to human ones.
Functional genomicist & Assistant Professor at The University of Texas Medical Branch at Galveston. https://www.ward-lab.org/
Gonçalves Lab @TUDelft (CS @EEMCS_TUD). Research on Computational Molecular Biomedicine, Machine Learning, Oncology by @joanagoncalves.bsky.social et al. Website: https://goncalveslab.tudelft.nl
We unite, organize, and mobilize progressive forces. Join us. https://progressive.international/
An international movement of ordinary people working to end the age of fossil fuels and build a world of renewable energy for all. 🧡
We're calling on governments in Europe and the UK to make the super-rich pay to fix the climate crisis. #TaxTheirBillions
Building a global, people-powered movement to end the fossil fuel era and create a world grounded in climate justice and powered by safe, fair renewable energy for all.