Maximilian Staps

Postdoc in Structural Biology of RNA processing complexes Postdoctoral positions in structural biology of macromolecular complexes are available in the laboratory of Dr. Eva Kowalinski at the EMBL Grenoble, France. We are looking for highly motivated and amb...

Postdoc positions in structural biology of RNA processing complexes.

An ERC-funded position will dissect pre-mRNA processing pathways in the infective organism Trypanosoma brucei. An ANR-funded position will characterise large complexes in RNA modification.

Details: tinyurl.com/postdoc-RNA-...

Essay mills shamelessly advertising on the academia feed. CC @keithwilson.eu

RMBase v3.0: decode the landscape, mechanisms & functions of RNA modifications
The Encyclopedia of RNA Epitranscriptome

More than m6A
"73 RNA modifications of 62 species"

bioinformaticsscience.cn/rmbase/

@narjournal.bsky.social 2024
academic.oup.com/nar/article/...

Scientists from our department 'Cardiac Development and Remodelling' discovered, that RBPMS and RBPMS2 regulate cell division and function during heart development, ensuring that the heart grows and matures correctly. Read the full paper in 'Developmental Cell' ➡️ lnkd.in/efwafKkE

Please consider eliminating your paywall on articles containing important information relevant to our current scientific crisis.

NSF halts grant awards while staff do second review Action comes after DOGE team arrives at science agency

The National Science Foundation has put a cork in its grantmaking pipeline after billionaire Elon Musk’s Department of Government Efficiency set up shop at the agency this week. scim.ag/4iowX4t

Light sheet microscopy Light sheet microscopy is a technology that enables near-isotropic imaging of large biological specimens over time. It opens new avenues to study biological processes with unprecedented imaging speed…

The @embo.org practical course on #lightsheet #microscopy is back!

Join us in #Dresden for 2 weeks with #your #samples, try the complete line-up of #lightsheet microscopes, tackle big data image analysis, sample prep, OA hardware & much more

Apply now!

Repost 🙏

meetings.embo.org/event/25-lsm

🤔

Are postdocs the rarest species, or is it just me? We have two funded positions—apply now and join us on these exciting projects! #zebrafish #zebrafishcareers #iPSC #devbio #regeneration

Single-cell expression during mouse gastrulation of genes enriched in probands with isolated congenital heart disease or neurodevelopmental delay and extracardiac findings. Single-cell RNA sequencing from mouse gastrulation for 28 genes associated with isolated CHD probands (in pink) or neurodevelopmental delay and extracardiac findings (in purple) are shown. On the vertical axis, cell types are sorted for heart (red), brain (blue), and other tissues (green). Expression levels are scaled to the greatest transcripts per million reads for each gene across all tissues. Chromatin genes are annotated with a white dot in the purple bar.

A genetic study of 11,555 people finds 60 genes implicated in congenital heart disease, a condition that affects 1–1.8% of all live births. The study could inform the development of early molecular diagnosis tools. In PNAS: www.pnas.org/doi/10.1073/...

iCLIP2, mapping protein-RNA interactions: from A to Z RNA is increasingly recognized as a key therapeutic target , driving the development of RNA-based therapeutics for a broad spectrum of diseases. RNA-binding proteins (RBPs) play a fundamental ro…

How to find binding sites or your favorite #RNA binding protein?

Join us for the EMBO practical course "iCLIP2, mapping protein RNA interactions: from A to Z". from 7.-12. September in Genoa, Italy

Learn more and register here:
meetings.embo.org/event/25-icl...

@embo.org @mixmue.bsky.social

A figure depicting an Ibex (representing the IBEX Knowledge-Base) at the top of a mountain, highlighting the guiding principles of the resource and how providing and sharing reagents, protocols and discoveries etc. can help with multiplexed imaging (ascending the mountain).

Multiplexed imaging is a powerful approach in spatial biology, but is complex, expensive & labor-intensive. This Community Page presents the IBEX Knowledge-Base, a central resource for reagents, protocols & more, to enhance knowledge sharing & innovation of multiplexing techniques.🧪
plos.io/41FoJP9

We're thrilled to share that Chiara won the 2nd prize in the poster awards category of Lung Inflammation and Repair at the first Institute for Lung Health (ILH) Symposium 2025 in Marburg! @ilh-lunghealth.bsky.social Chiara is PHD at the Salwig Group in the Dept. of Cardiac Development & Remodelling.

Current job offers

We offer 2 PhD Positions in Evolutionary Biology!

1️⃣ Evolutionary Developmental Biology – Craniofacial evolution. (March 31, 2025)

2️⃣ Evolution of Polygenic Traits – Genetic adaptation in Drosophila. (April 30, 2025)

More here: www.evolbio.mpg.de/1639156/Job_...

#PhD #EvoDevo #Genetics

Detailed charts of fetal hearts

Read this Research Highlight showcasing work from Christopher De Bono, Stéphane Zaffran, Heather Etchevers @etche.bsky.social & colleagues:
journals.biologists.com/dev/article/...

Very thought-provoking Essay "The end of the genetic paradigm of cancer" arguing against the primacy of the somatic mutation model of #cancer in favor of the emergent properties of gene regulatory networks and tissue context
plos.io/3DRtAEW
🧪

Scientists Take on Scholarly Journals With Walkouts, Scathing Letters and Delistings Some scientists say the for-profit industry’s fast growth makes it harder to police fraud and low-quality work.

Scientists Take on Scholarly Journals With Walkouts, Scathing Letters and Delistings: Some scientists say the for-profit industry’s fast growth makes it harder to police fraud and low-quality work

Search for Postgraduate Scholarships and Other Funding We know that how you fund your postgraduate studies is very important. Our funding database gets you to the information you need quickly.

We are still taking applications for this exciting @thebhf.bsky.social funded #PhD Studentship investigating the #genetics of #cardiovascular development at @newcastleuni.bsky.social. Please spread the word and share to your networks! Apply here: tinyurl.com/yc6paa5w.

To all people familiar with embryonic mouse hearts:
Am I going crazy or did the authors of this figure mixed up the left and right ventricle?

@science.org Cryo-EM reveals mechanisms of natural RNA multivalency | Science www.science.org/doi/10.1126/...
#RNAsky #RNAbiology #Cryo-EM

Man lives for 100 days with artificial titanium heart in successful new trial | CNN An Australian man lived for 100 days with an artificial titanium heart while he awaited a donor transplant, the longest period to date of someone with the technology.

News of the first Australian patient to receive a BiVACOR Total Artificial Heart made headlines around the world and saw media descend on the Institute to talk with Professor Chris Hayward, BiVACOR founder Daniel Timms and St Vincent’s Hospital Sydney surgeon Paul Jansz: edition.cnn.com/2025...

Intrinsically disordered regions as facilitators of the transcription factor target search Nature Reviews Genetics, Published online: 21 February 2025; doi:10.1038/s41576-025-00816-3Intrinsically disordered domains (IDRs) are increasingly appreciated as important components of protein function. This Perspective discusses the emerging evidence…

FYI: New online! Intrinsically disordered regions as facilitators of the transcription factor target search

Open PhD position in our RTG2355 - great diversity in topics, invited speakers, retreats and symposia, workshops, soft skill courses - and very nice people!

RNA xkcd.com/3056

@philipcball.bsky.social

Cytoplasmic mRNA decay and quality control machineries in eukaryotes Nature Reviews Genetics, Published online: 27 January 2025; doi:10.1038/s41576-024-00810-1In this Review, Dowdle and Lykke-Andersen discuss advances in our understanding of the machinery and mechanisms involved in the control of cytoplasmic mRNA decay and…

FYI: New online! Cytoplasmic mRNA decay and quality control machineries in eukaryotes

Photo of a portrait shaped clay tablet with well-preserved cuneiform signs.

Photo of a portrait shaped clay tablet with well-preserved cuneiform signs.

In this ancient Assyrian letter, astronomers complain that they can’t do their jobs or teach astronomy “because of the ilku-duty”, a type of taxation in the form of labour.

“we cannot keep the watch of the king, and the pupils do not learn the scribal craft” cdli.mpiwg-berlin.mpg.de/artifacts/33...

Now official: We have another opening for a fully funded #PhDposition in the Beusch lab (www.beuschlab.org) at @uniwuerzburg.bsky.social! More details here: tinyurl.com/947xcw85 If you or someone you know is curious about #splicing please apply or contact me for more information! #RNAsky #RNAbiology

A piece of science history about RNA, oxygen, and mice cages

There is nothing is more important in an experiment than the proper controls. But what should you do if your experimental control fails? - read my short essay on failed experimental controls.

www.embopress.org/doi/full/10....?

‘Publish or perish’ culture blamed for reproducibility crisis Survey of more than 1,600 biomedical researchers also flagged small sample sizes and cherry-picking of data as leading causes of reproducibility problems.

“Until we acknowledge that publish or perish is the natural consequence of the rankings obsession, we’re not going to fix anything.”

Our Ivan Oransky speaks with @nature.com.