Srimeenakshi S

Great time visiting the groups of Carmo Fonseca, Joel Perez-Perri, and Nuno Morais (@nmoraislab.bsky.social) at Gulbenkian Institute for Molecular Medicine (GIMM) in Lisbon 🇵🇹

Thanks for great discussions on nuclear speckles, RNA-binding proteins, and other exciting topics!

#ScienceVisit #RNA #GIMM

We’re kicking off the bioinformatics part of the #emboiclip2 course today! Excited to dive into the data side of iCLIP. 💻🧬

Super! Thanks :)

@zarnack-group.bsky.social

hurray!! @zarnack-group.bsky.social is in bluesky!! 🎉

iCLIP2, mapping protein-RNA interactions: from A to Z RNA is increasingly recognized as a key therapeutic target , driving the development of RNA-based therapeutics for a broad spectrum of diseases. RNA-binding proteins (RBPs) play a fundamental ro…

How to find binding sites or your favorite #RNA binding protein?

Join us for the EMBO practical course "iCLIP2, mapping protein RNA interactions: from A to Z". from 7.-12. September in Genoa, Italy

Learn more and register here:
meetings.embo.org/event/25-icl...

@embo.org @mixmue.bsky.social

Invitation to the 8th Rhineland RNA Club meeting on 28 March at the MPI for Biology of Ageing At 9:30 am with Julian König, Kathrin Leppek, David Koppstein, Andromachi Pouikli and Michael Feldbrügge as speakers. The event is supported by the RNA Society, Lexogen, siTools, Twist and Immagina.

We are very happy to invite you to our 8th edition of the Rhineland RNA Club @mpiage.bsky.social with great local speakers and Julian König @koenig-lab.bsky.social as our invited speaker. All #RNA enthusiasts are welcome. Organized by @katleppek.bsky.social and @inahuppertz.bsky.social. #RNAsky

Robert-Koch-Postdoktorandenpreis für den Themenbereich Immunologie (€ 5.000) / Bewerbungsschluss: 14. März 2025

Die DGfI hat ein Vorschlagsrecht für den Robert-Koch-Postdoktorandenpreis im Bereich Immunologie.

Mehr Informationen unter: dgfi.org/preise/koch-...

PhD position vacant in the lab. Please spread the news. Study topic: Mammalian nuclear RNA production and turnover systems. Learn more about the lab here: www.mRNP.au.dk

Postdoc positions in Nuclear RNA Biology - Vacancy at Aarhus University Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University

New postdoc opportunity in the THJ lab! Please share to anyone interested in nuclear RNA biology
@molbiolau.bsky.social

mbg.au.dk/en/news-and-...

Hello Everyone! 👋 Nucleic Acids Research is excited to be on Bluesky! Please follow us for the latest #Research, #Breakthrough articles, journal issues and more. Also, please consider adding us to your starter packs!

"m6A ‘encodes’ a dedicated mRNA decay pathway". Thank you Eytan for highlighting our work in @natrevmcb.bsky.social

Read the story here:
www.nature.com/articles/s41...

#RNA #m6A #translation

PS: Still thinking what the banana means.

Pathogenic proteotoxicity of cryptic splicing is alleviated by ubiquitination and ER-phagy RNA splicing enables the functional adaptation of cells to changing contexts. Impaired splicing has been associated with diseases, including retinitis pigmentosa, but the underlying molecular mechanis...

It is finally out! My first Science paper is online and it does not seem real😃. I am Incredibly happy! Really thanks to all my coauthors and special mention to my incredible supervisor Ivan Dikic for all the support and trust ! 🫶. #RNA #Proteostasis #ubiquitin #autophagy #RP
doi.org/10.1126/scie...

Specific tRNAs promote mRNA decay by recruiting the CCR4-NOT complex to translating ribosomes The CCR4-NOT complex is a major regulator of eukaryotic messenger RNA (mRNA) stability. Slow decoding during translation promotes association of CCR4-NOT with ribosomes, accelerating mRNA degradation....

I’m thrilled to share a collaborative story from @Mendell_lab and Jan Erzberger labs, led by postdoc extraordinaire Xiaoqiang Zhu. We showed that in addition to their canonical decoding function, tRNAs play a key role in regulating mRNA stability during translation!
www.science.org/doi/10.1126/...

#RNASky

The PUF RNA-binding protein, FBF-2, maintains stem cells without binding to RNA Like all canonical PUF proteins, C. elegans FBF-2 binds to specific RNAs via tripartite recognition motifs (TRMs). Here we report that an FBF-2 mutant protein that cannot bind to RNA, is nonetheless b...

I’m excited to share this story. We found that mutating an RNA binding protein’s ability to bind RNA did not remove all biological function, but when combined with a mutation that affects protein interactions, the RBP no longer functioned.

www.biorxiv.org/content/10.1...