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Manil Kanade

@manilk.bsky.social

Postdoc at @UCPH in the Thomas Miller group | DNA Repair & Replication | PhD with Silvia Onesti| X-ray Crystallography & Cryo-EM | MSCA Alumni|IISERPUNE

153 Followers  |  294 Following  |  2 Posts  |  Joined: 17.11.2024  |  1.6944

Latest posts by manilk.bsky.social on Bluesky

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Check out this new review (with animations, natch) of mechanisms of licensing origins of DNA replication - a wonderful (and continuing!) collaboration with Bruce Stillman @cshlnews.bsky.social and John Diffley @crick.ac.uk! www.nature.com/articles/s41...

02.07.2025 17:01 β€” πŸ‘ 78    πŸ” 43    πŸ’¬ 6    πŸ“Œ 2
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Postdoctoral Research Associate in the Blackford Group A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.

Please get in touch with your CV if you are interested; closing date: 27th June 2025.

More details here: candidate.hr-manager.net/ApplicationI...

29.05.2025 11:26 β€” πŸ‘ 23    πŸ” 35    πŸ’¬ 0    πŸ“Œ 0
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Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability Losing parental histones during DNA replication fork passage challenges differentiation competence and cell viability.

𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞π₯π₯𝐬 π«πžπ¦πžπ¦π›πžπ« 𝐰𝐑𝐨 𝐭𝐑𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩π₯𝐒𝐜𝐚𝐭𝐒𝐨𝐧? Our new study β€œDisabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘀π˜ͺ𝘦𝘯𝘀𝘦 𝘈π˜₯𝘷𝘒𝘯𝘀𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧡 More belowπŸ‘‡

19.02.2025 19:35 β€” πŸ‘ 112    πŸ” 53    πŸ’¬ 5    πŸ“Œ 5
DNA replication in primary hepatocytes without the six-subunit ORC

Happy to close 2024 with my last first-author publication from PhD thesis: "DNA replication in primary hepatocytes without the six-subunit #ORC" in @elife.bsky.social. This study challenges existing paradigms in #DNAreplication. 🧡(1/4)
elifesciences.org/reviewed-pre...

01.01.2025 20:57 β€” πŸ‘ 17    πŸ” 7    πŸ’¬ 3    πŸ“Œ 0

Congrats Chiara πŸ˜ƒ

04.12.2024 20:42 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
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Our article "MCM double hexamer loading visualized with human proteins" published in Nature today! β„οΈπŸ”¬πŸ§¬πŸŽ‰πŸ₯³

Great collaboration with John Diffley's lab. Congratulations to Florian Weissmann, Julia Greiwe and all other authors!

rdcu.be/d1F7m

27.11.2024 17:24 β€” πŸ‘ 170    πŸ” 44    πŸ’¬ 10    πŸ“Œ 5
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DNA REPAIR/GENOME STABILITY CONFERENCES

New updates to the upcoming DNA repair/Genome Stability conferences over 2024/2025. Please let me know if you have meetings to add:
docs.google.com/spreadsheets...

12.11.2024 04:57 β€” πŸ‘ 38    πŸ” 15    πŸ’¬ 2    πŸ“Œ 0
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Faster and more accurate protein modeling with CryFold. By focusing on nearby points (Local Attention) and employing map masking, CryFold excels in generating models from challenging maps regions. It enables a more cost-efficient model building. 🧡
πŸ’Ύ github.com/SBQ-1999/Cry...

25.11.2024 17:24 β€” πŸ‘ 110    πŸ” 38    πŸ’¬ 1    πŸ“Œ 3

Glad to be part of this amazing team! Looking forward to the next science adventure. πŸš€πŸ”¬ #Teamwork #Science

25.11.2024 11:18 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

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