Tyler Garretson

Autoimmune response to C9orf72 protein in amyotrophic lateral sclerosis - Nature An analysis of T cell responses in people with amyotrophic lateral sclerosis shows that the C9orf72 antigen is a key target of autoimmune responses in the disease, and identifies C9orf72 epitopes that are recognized.

Well, this is exciting! An autoimmune mechanism for the horrible disease ALS has been identified, for the first time. #ImmunoSky
🧪
www.nature.com/articles/s41...

Remembering David Baltimore, a titan who transformed biology and spoke bluntly The influential Nobel laureate ran institutions, trained future scientific leaders, survived a scandal, and shaped policy

David Baltimore, for much of the past three decades, has been one of my most helpful, thoughtful sources. I wrote an obit about his remarkable career, and I included a few of my interactions with him. www.science.org/content/arti...

These kind of analyses and tech only improves our flu vaccine strain selection, hopefully leading to overall higher vaccine effectiveness.

Dementia is deadly — the UN needs to take it more seriously Improved recognition of dementia as a major non-communicable disease by multilateral organizations is crucial, to build awareness and increase funding to tackle this insidious illness.

Inclusion of #dementia in the WHO’s and UN’s discussions about non-communicable diseases could drastically change attitudes worldwide and could improve access to care and support for people living with the condition and their carers, writes Paola Barbarino in Nature. 🧪

Congrats to the team! Important findings.

Bovine H5N1 binds poorly to human-type sialic acid receptors - Nature Nature - Bovine H5N1 binds poorly to human-type sialic acid receptors

After 8 months of peer review, our manuscript was published today @nature.com showing that bovine H5N1 viruses bind poorly to human-type sialic acid receptors. We now know that the virus is only 1 HA substitution away from efficiently binding human receptors.

www.nature.com/articles/s41...

Role of Blood–Brain Barrier Dysfunction in Delirium following Non‐cardiac Surgery in Older Adults Objective Although animal models suggest a role for blood–brain barrier dysfunction in postoperative delirium-like behavior, its role in postoperative delirium and postoperative recovery in humans i...

As someone who’s father passed from Lewy Body, I always felt there was a link between the 14 hr back surgery he had followed by severe post surgery symptoms and his eventual Lewy Body diagnosis. I read this recently and found this BBB field to be crucial to understanding these neurodegen disorders.

This is figure 2, which shows that H5-reactive antibody levels correlate better with birth year than age.

H5N1 strain-specific antibodies are higher in older individuals and correlate more with birth year than with age, suggesting that younger individuals are potentially more likely to benefit from H5N1 vaccination, according to a paper in Nature Medicine. https://go.nature.com/4hFLOa5 🧪

Couldn’t be happier to see this out. It was a fun collaboration with the talented @cobey.bsky.social lab. Access to vital clinical resources and powerful tech at Penn allowed us look at Ab levels in this cohort to help answer these questions.

Immune history shapes human antibody responses to H5N1 influenza viruses - Nature Medicine H5N1 strain-specific antibodies are higher in older individuals and correlate more with birth year than with age, suggesting that younger individuals are potentially more likely to benefit from H5N1 v...

Today @natmedicine.bsky.social published our study showing the older individuals born prior to 1968 have more antibodies that cross-react to #H5N1 relative to younger individuals. If H5N1 causes a pandemic, children will likely be the most susceptible. 1/2

www.nature.com/articles/s41...

Very close to my heart. The power of vaccines and basic research merging to help patients. We need more of it!

Dementia risk, higher than thought, requires a national strategy The risk of developing dementia may be double what was previously thought. But there are things the U.S. can do to help fight that — like turning to the arts.

Dementia risk, higher than thought, requires a national strategy: Policies and industries that promote healthy aging are imperative www.statnews.com/2025/01/18/d... #AlzheimersDisease #dementia #healthcare

Using lab-grown human mini-brains, scientists find links between head trauma, herpes, and Alzheimer’s Research published Tuesday is the first to connect the dots between a common herpes virus, head injury, and Alzheimer's.

Research published Tuesday is the first to connect the dots between a common herpes virus, head injury, and Alzheimer's.

Immunofocusing on the conserved fusion peptide of HIV envelope glycoprotein in rhesus macaques https://www.biorxiv.org/content/10.1101/2024.11.27.625755v1 During infection, the fusion peptide (FP) of HIV envelope glycoprotein (Env) serves a central role i

Immunofocusing on the conserved fusion peptide of HIV envelope glycoprotein in rhesus macaques https://www.biorxiv.org/content/10.1101/2024.11.27.625755v1

Modulating the immunodominance hierarchy of immunoglobulin germline-encoded structural motifs targeting the influenza hemagglutinin stem Ataca et al. describe a pathway to generate cross-reactive B cells against influenza hemagglutinin by engaging a subdominant immunoglobulin germline-encoded motif through prime-boost vaccination in IG...

📢Hot off the press! Our latest work studying #influenza broadly neutralizing antibody development in humanized mice. Huge thanks to everyone involved in the study🙏 #NIAID #VRC #Ragon #Scripps www.cell.com/cell-reports...

A B cell screen against endogenous retroviruses identifies glycan-reactive IgM that recognizes a broad array of enveloped viruses Profiling of ERV-reactive B-1 cells in mice reveals natural antibodies against terminal N-acetylglucosamine on multiple viral envelope proteins.

This #glycotime work by @virusesimmunity.bsky.social is intriguing; terminal GlcNAc is a viral epitope recognized by Abs that keep endogenous retroviruses at bay. Must be something about the context of that GlcNAc, would love to see some followup structural biology.

www.science.org/doi/10.1126/...

Last week, a teenager in British Columbia contracted H5N1, the first human case acquired in Canada. The BC CDC and and Canadian Food Inspection Agency have released sequences from this infected person and domestic and wild birds sampled in BC, which we've just added to Nextstrain. A thread: