Alice Godden

📢🚨Please share! We’re hiring! 📢🚨Have a strong interests in wildlife ecology and gut microbiome bioinformatics? 3 year Senior Research Associate for NERC Pushing the Frontiers grant. Apply here: vacancies.uea.ac.uk/vacancies/18.... Informal enquiries welcome! drgldavidson.github.io/ACMEresearch

Takeaway: even “simple” dietary fibres can ripple across the microbiota–gut–brain axis — and dosage + sex differences matter. 🐟

And it wasn’t the same for everyone:
♀️ High gum Arabic had negative impacts on female reproductive fitness.
♂️ But in males, effects were mostly beneficial.

🐟 Gum Arabic reshaped the gut microbiome (↓ Proteobacteria, ↑ Cetobacterium).
🧠 Changed brain metabolism (↑ acetate at high doses).
🧬 Altered gene expression linked to appetite + energy use.

Gum Arabic modulates the microbiota-gut-brain axis and affects general fitness in zebrafish - Scientific Reports Scientific Reports - Gum Arabic modulates the microbiota-gut-brain axis and affects general fitness in zebrafish

🧬 Our latest paper out in Scientific Reports!
We explored how Gum Arabic (a dietary fibre) affects the microbiota–gut–brain axis and whole-organism fitness in zebrafish.

🔗 www.nature.com/articles/s41...
@immler.bsky.social @biouea.bsky.social

What we found ⬇️

Schematic overview of our project. Dissection of Xenopus neural crest following morpholino knockdown of miRNA, then extraction of RNA for RNA-seq

Our new paper is out in Dev Biol! 🎉 🐸🧬
We show #miR-196a directs #neural crest fate in #Xenopus by repressing immature neural #ectoderm — evidence #miRNAs can potentially drive, not just fine-tune, early patterning
👉 Read more here: doi.org/10.1016/j.yd...
@devbiol.bsky.social @biouea.bsky.social

Big thanks to the organisers and chairs for accepting my abstract, this was such a great session to be a part of 🧬🔥🌎🐟

Join Join Society for Open, Reliable, and Transparent Ecology and Evolutionary biology (SORTEE)

Thanks to all those that attended the @sortee.bsky.social led symposium at #ESEB2025 and for those that met up on Wednesday!!

If you’re interested in joining SORTEE and supporting open science in EcoEvo, consider becoming a member!

sortee.org/join/

a wolf is standing in the snow with its mouth open and looking at the camera . ALT: a wolf is standing in the snow with its mouth open and looking at the camera .

Screaming into the blue void: anyone out there interested in some long-read #pacbio #european #wolf #sequence data? We have too much data from a pilot to not use, but it is too little data to assemble a #T2T on our own. Open to #collaboration. Get in touch!

Thank you, what a cool session!

Now on my way to #ESEB2025, Barcelona here we come!

Photo shows Jean-Baptiste Raina, a smiling man wearing round glasses, with a dark, trimmed beard and a dark cap.

Today’s the day! Our 2025 Research Colloquium, celebrating the research taking place here in BIO, starts at 09:30 in the Thomas Paine Study Centre. A fantastic day of talks awaits us, including our guest speaker Jean-Baptiste Raina of the University of Technology, Sydney!
#UEABioResearch
#UEAScience

🔍 From the origins of life to cutting-edge genomic tools, the hashtag#ESEB2025 𝐬𝐜𝐢𝐞𝐧𝐭𝐢𝐟𝐢𝐜 𝐩𝐫𝐨𝐠𝐫𝐚𝐦 𝐢𝐬 𝐚𝐬 𝐛𝐫𝐨𝐚𝐝 𝐚𝐬 𝐢𝐭 𝐢𝐬 𝐛𝐨𝐥𝐝.

With more than 50 symposia led by international experts, 𝐭𝐡𝐞𝐫𝐞’𝐬 𝐬𝐨𝐦𝐞𝐭𝐡𝐢𝐧𝐠 𝐟𝐨𝐫 𝐞𝐯𝐞𝐫𝐲 𝐞𝐯𝐨𝐥𝐮𝐭𝐢𝐨𝐧𝐚𝐫𝐲 𝐛𝐢𝐨𝐥𝐨𝐠𝐢𝐬𝐭.

📖 Explore the full list of symposia:
🔗 https://lnkd.in/da5JU3mv

Norwich Single-Cell and Spatial Symposium Now in its eighth year, and extended to a two-day event, the Norwich Single-Cell and Spatial Symposium at Earlham Institute covers single-cell and spatial genomics technologies and their application…

Registered for #EISingleCell25 yet? 🧬 🖥️

We'll be hearing Dr Pascal Barbry, Research Director at the Institute of Molecular and Cellular Pharmacology, about integrating different #singlecell techniques to compare and understand healthy and pathological lung function.

Timeline of important technological developments in zebrafish research.

With a published genome & advancements in gene editing, the field of #zebrafish genetics has exploded in recent decades. We take a look back at major achievements in this infographic. For more, read this book chapter by @varshneylab.social et al (2015)($) doi.org/10.1016/bs.a... #ZebrafishFunFacts 🧪

🧵 🧪 1/ Female #ReproductiveBiology is, unfortunately, notoriously understudied.

So maybe it’s no surprise that a supposedly useless ‘developmental leftover’ in the ovaries could turn out to be...not so useless after all.

Meet the rete ovarii 👇
buff.ly/VudxQ2U

Introducing the brand new Starter Pack of staff, PhD students and related accounts, from the School of Biological Sciences, UEA.
Follow us...
#UEAScience
go.bsky.app/PLSJXMz

Thanks 🐠😃

Environmentally induced variation in sperm sRNAs is linked to gene expression and transposable elements in zebrafish offspring Heredity - Environmentally induced variation in sperm sRNAs is linked to gene expression and transposable elements in zebrafish offspring

🔬 My latest work w/ @immler.bsky.social et al: Env. stress alters sperm sRNAs, linking gene expr. + transposons in #zebrafish offspring. @heredityjournal.bsky.social
🧬 Social stress shapes RNA/TE activity across generations
#Sperm #miRNA #piRNA #Transposons #TEsky @biouea.bsky.social
rdcu.be/eeAwB

A still image of a stage HH4 gastrulating chick embryo electroporated with 3 different fluorescent reporter genes shown in magenta, yellow and cyan.

Need to electroporate and/or live image avian embryos? We hope our new preprint will help you get started:

www.biorxiv.org/content/10.1...

Open EGGbox: an open-source 3D-printed embryonic Gallus gallus toolbox for electroporation and culture/live imaging of avian embryos ex ovo

🧪🐣 #devbio

MicroRNA miR-196a controls neural crest patterning by repressing immature neural ectoderm programs in Xenopus embryos. Neural crest (NC) cells form a multipotent stem cell population specified during neurulation, which undergo an epithelial-to-mesenchymal transition (EMT) and migrate extensively in the developing embr...

Pleased to share my latest pre-print from my PhD work
🚨MicroRNA miR-196a controls neural crest patterning by repressing immature neural ectoderm programs in Xenopus embryos. 🐸🧬 @biouea.bsky.social

#miRNA #Xenopus #neuralcrest #ectoderm #RNA-seq
www.biorxiv.org/content/10.1...

Currently has reference files for zebrafish, medaka and tilapia fish. More species can be added. Full instructions provided if you wish to generate your own species input TE and piRNA files for analysis.

FishPi software logo

🚨Our new paper @immler.bsky.social @biouea.bsky.social 🚨
FishPi: a #bioinformatic prediction tool to link #piRNA and #transposable elements
Read now in Mobile DNA >> rdcu.be/d7Jub
✅ Covers many species (more to come)
✅ GUI based software
#TESky #zebrafish #transposons
@zebrafishrock.bsky.social

Highlights include new works from @smeetonlab.bsky.social, @alicegodden.bsky.social, @immler.bsky.social & Misty Riddle (#cavefish) 🐟 #WomenInScience

The Zebrafish Sperm Proteome One of the key processes that forms the basis of fertilisation is the tight interaction between sperm and egg. Both sperm and egg proteomes are known to evolve and diverge rapidly even between closel...

🚨New paper from @immler.bsky.social lab
Led by Jayme Cohen doi.org/10.1002/pmic...
On the #Zebrafish #sperm proteome out now! 🐠

Applications close Friday (20) for PhD projects as part of the @daniorecode.bsky.social MSCA doctoral network.

Project available with Prof Irene Papatheodorou working on comprehensive cell atlases of regeneration in three different species. #zebrafish #singlecell

Climate change extinctions Climate change is expected to cause irreversible changes to biodiversity, but predicting those risks remains uncertain. I synthesized 485 studies and more than 5 million projections to produce a quant...

"Rising temperatures will lead to an increasing number of extinctions, with the highest emission scenario leading to extinction of nearly a third of the Earth’s species, especially those from particular vulnerable taxa or regions."

www.science.org/doi/10.1126/...

Thanks 🐻‍❄

The new features and information on exportable results should help address these concerns. 👍

Other fish are available with this tool (any organism) but zebrafish are my favourite 😍