Dan Isom

Help me Challenge Cancer! The DCC is a year-round collective community movement to raise money in support of Sylvester Comprehensive Cancer Center at the University of Miami. With your support, we are saving more lives. #OneTe...

Support my running of the 5K! Funds go directory to research labs @SylvesterCancer: dolphinscancerchallenge.com/participant/...

These mutations mimic protonation (i.e., activation) and, along with abolishing Na+ negative allosteric modulation, were intended to fully activate GPR4, 65, and 68 precisely as they did

There is a misunderstanding here. These mutations were not designed to abolish proton-mediated activation but to achieve the exact opposite based on the predicted physical chemistry and self-energy considerations.

"A recent study employing parallel mutagenesis of titratable residues in GPR68 identified a conserved triad of buried acidic residues in proton sensing GPCRs. Here, too, neutral mutations to these sites shift pH50 but do not abolish proton-mediated receptor activation."

I have received many requests for this, so I am sharing it here. I hope it works (password: 7i+fFdMG) @Pap_Corps @SylvesterCancer @danIsomLab:
tinyurl.com/Pap-Corps-EC...

Thanks Nina!

Welcome! You are invited to join a webinar: The Pap Corps Champions for Cancer Research Endowed Chair. After registering, you will receive a confirmation email about joining the webinar. Chair ceremony for Dr. Daniel G. Isom

miami.zoom.us/webinar/regi...

The combined single-day profit of the top 25 US companies would fully fund the annual $3.2B NIGMS budget.

Happy Thanksgiving from Miami.

Can a Diabetes Drug and Immunotherapy Help Treat Brain Cancer? - InventUM Defne Bayik, Ph.D., is pioneering new treatments to find combination therapies that may help T-cell response against glioblastoma.

Yay Defne! news.med.miami.edu/can-a-diabet...

In my excitement for his visit, I forgot to get a selfie with Henrik. This will have to do 😂

Advances in yeast synthetic biology for human G protein–coupled receptor biology and pharmacology G protein–coupled receptors (GPCRs) are the largest family of transmembrane receptors in humans. Over 800 GPCRs regulate the (patho)biology of every o…

Our small review on using yeast synthetic biology to advance human GPCR biology and pharmacology.
tinyurl.com/2p88y72h

What a wonderful scientific retreat for UM Pharmacology this week @bakerscayresort. Time is running out to join our faculty and enjoy the Keys and science for yourself! bit.ly/3GAxDD6

Looking for cool colleagues! Recruiting at assistant and associate levels. I am happy to answer any questions. www.nature.com/naturecareer...

Chicagoland.

SUP on Lake Tahoe today:

Happy to be among this fine assembly of protonators: https://www.biophysics.org/2023tahoe-protonreaction/program/daily-schedule

Sugar gold.

I would.

That bill is strangely pleasing.

Wow, SoCal feeling SoFlo.

Otterly astounding ;)

Love the graphic.

PIEZO1 action up close: https://www.nature.com/articles/s41586-023-06427-4

Cool, but SUPER TINY proteins: https://www.nature.com/articles/s41586-023-06328-6

I share your whoa!

STING may be a proton channel: https://www.science.org/doi/10.1126/science.adf8974?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed