Northwestern Basic Sciences

A calendar page with a red pushpin marking a date. Text reads: “Join Us for Basic Science Events & Seminars – November 2025.” Northwestern Medicine Feinberg School of Medicine logo appears at the bottom

Join us for basic science events and seminars in November.

🔗Explore upcoming talks, lectures and discussions: tinyurl.com/2tvstbce

Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle The de novo purine synthesis pathway is fundamental for nucleotide production, yet the role of mitochondrial metabolism in modulating this process rem…

Excited to share our latest work out today in @cp-molcell.bsky.social, revealing a molecular link between succinate dehydrogenase and purine synthesis, connecting two fundamental metabolic pathways. Huge congratulations to the first author, Mushtaq Nengroo! www.sciencedirect.com/science/arti...
!

Online Now: Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle Online now:

Understanding Cellular Impacts of Neurodegeneration - News Center A Northwestern Medicine study has revealed a key mechanism underlying the development of motor neuron diseases, offering new insights into potential treatment options, according to a study published i...

DGP grad Sun Kim was first author of a recent study published in the Journal of Neuroscience! Read about the study: news.feinberg.northwestern.edu/2025/10/16/u...

Goyal Named Mallinckrodt Foundation Grant Fellow  - News Center Yogesh Goyal, PhD, assistant professor of Cell and Developmental Biology, has been named a 2025-2028 Edward Mallinckrodt, Jr. Foundation Grant Fellow, which recognizes early-stage biomedical investiga...

Congratulations to Dr. Yogesh Goyal on his appointment as a Mallinckrodt Foundation Grant Fellow!

Dr. Goyal is an active member of our CRS community, including serving as MS-RSM mentor and T32 faculty member.

news.feinberg.northwestern.edu/2025/10/13/g...

Portrait of Yogesh Goyal, PhD, assistant professor of Cell and Developmental Biology at Northwestern University Feinberg School of Medicine, smiling against a purple gradient background. Text reads: “Goyal Named Mallinckrodt Foundation Grant Fellow.” Northwestern Medicine Feinberg School of Medicine logo appears in the lower right corner.

Congratulations to Yogesh Goyal, PhD @goyallab.bsky.social, who was named a 2025–2028 Edward Mallinckrodt, Jr. Foundation Grant Fellow!

His work bridges engineering and biology to advance understanding of cellular plasticity and fate in development and disease. Learn more: tinyurl.com/2rumf48v

CAM Director Dina Arvanitis is currently in Banos, Ecuador, where she is co-organizer of the @biologists.bsky.social workshop Democratizing Microscopy in Latin America together with Mario Del Rosario, Fernanda Latorre, Helena De La Torre, Licyel Paulas, and Mariana De Niz. @nu-bsa.bsky.social

Thanks for highlighting the work of Nikon Center Manager at CAM, Mariana De Niz. All the best at the Ecuador workshop!!! @nu-bsa.bsky.social @latambioimaging.bsky.social @bioimagingna.bsky.social

Portrait of Richard Smith, PhD, assistant professor of Pharmacology and Pediatrics at Northwestern University Feinberg School of Medicine, with text reading “Smith Honored with NIH New Innovator Award” over a purple background featuring an illustrated brain outline.

Congratulations to Richard Smith, PhD, on receiving the prestigious NIH Director’s New Innovator Award, recognizing early-career scientists leading high-risk, high-impact research in the biomedical, behavioral or social sciences.

Learn more about his work: tinyurl.com/yrhnk7bn

NIH, My NCBI and PMCIDs - Virtual Q & A "Office Hours" Date: Fri, October 10 11:00 AM CDT Location: Online (Zoom) Conducting a Systematic Review: Part 2 - Tools & Resources Date: Wed, October 15 1:00 PM CDT Location: Online (Zoom) EndNote Date: Thu, October 16 12:00 PM CDT Location: Online (zoom) NIH Public Access Policy and Publication Management with MyNCBI Date: Thu, October 16 12:00 PM CDT Location: Online (Zoom) Feinberg Founders & Notables: Historical Walking Tour of Graceland Cemetery Date: Fri, October 17 2:00 PM CDT Location: Graceland Cemetery & Arboretum Prism: collect, share, and preserve the full spectrum of your work Date: Tue, October 21 9:00 AM CDT Location: Online (Zoom) ORCID: Register, Use, Share Date: Tue, October 21 10:00 AM CDT Location: Online (Zoom) PubMed Date: Tue, October 21 10:00 AM CDT Location: Online (Zoom) Northwestern Elements Date: Tue, October 21 11:00 AM CDT Location: Online (Zoom) Proofig AI Training: Research Integrity with Automated Image Verification Date: Wed, October 22 12:00 PM CDT Location: Online (Zoom) Using SciENcv for NIH Biosketches and Other Support Documents Date: Thu, October 23 12:00 PM CDT Location: Online (Zoom) Getting to Know the NIH Policy on Data Management and Sharing Date: Mon, October 27 10:00 AM CDT Location: Online (Zoom)

Join us this October for our virtual classes! Register here: galter.northwestern.edu/classes

Postdoctoral Position (Please re-post)
A funded postdoctoral position, will open in 2026 to study aspects of Neisseria gonorrhoeae pathogenesis, antigenic variation, genetics, or physiology.
If interested in more information, please contact Hank Seifert
h-seifert@northwestern.edu

Archway on the Northwestern Chicago campus with fall trees in the background. A large purple “NN” overlays the image. White text reads: “Join Us for Basic Science Events & Seminars, October 2025

🍂 This October, explore our basic science events and seminars showcasing exciting research and join us for opportunities to connect with colleagues across Feinberg.

Check out the full lineup here (link updated)👉 tinyurl.com/39z88nkp

Graphic with the Northwestern Medicine logo and text that reads: 'Congratulations to Our Recently Promoted Faculty.' Six faculty headshots appear on the right, grouped under the headings 'Biochemistry and Molecular Genetics' and 'Pharmacology

🎉 Congratulations to our recently promoted faculty in the Departments of Biochemistry and Molecular Genetics and of Pharmacology! We’re proud to celebrate their achievements in advancing science, education and discovery at Feinberg and beyond.

Delight to see that our work on vimentin intermediate filament dynamics is part of JCB’s Special Collection: Intermediate Filaments 2025!!! Check it out: rupress.org/jcb/collecti... @jcb.org @nucdb.bsky.social @nu-bsa.bsky.social @hhmijanelia.bsky.social

Investigating How Tumor-Immune Cell Clusters Drive Cancer Spread  - News Center In a pair of studies, investigators from the lab of Huiping Liu, MD, PhD, have uncovered how specific cellular interactions in the bloodstream may be fueling the spread of breast cancer.

Huiping Liu, MD, PhD, and team reveal how tumor–immune cell clusters fuel #BreastCancer metastasis in a pair of new studies published in @natcomms.nature.com and @jclinical-invest.bsky.social.

Goyal Lab

**POSTDOC POSITION** My lab (www.goyallab.org) at Northwestern and CZ Biohub Chicago looking for a postdoctoc in quantitative biology. We work on a range of topics, including single-cell cancer plasticity, modeling single-cell perturbations, theory, and stem-embryo models. contact via email. Pls RT

Premature babies with bronchopulmonary dysplasia show enlarged airspaces and vascular damage.

@lisyvila.bsky.social and team investigate endothelial injury in a mouse model of neonatal hyperoxia, revealing a key role for p53 in maintaining EC identity during repair.

buff.ly/YUPSp4W

Welcome banner for new students featuring four labeled sections—Research, Collaboration, Innovation, and Excellence—with corresponding student activity scenes.

Welcome new @nufeinbergmed.bsky.social students! We’re excited to support you as you start this new journey! Get to know the library and start using the resources available to you 📚

Follow this link to a quick reference guide: galter.northwestern.edu/news/find-yo...

Global Health Day call for abstracts

📣Call for Abstracts📣

Apply to present a poster on a project relevant to global health at this year's Global Health Day!

Abstract submissions are open: www.globalhealth.northwestern.edu/events/global-health-day/

Deadline to submit: Wed, Sept 24

#globalhealthday #globalhealthday2025

Two gold medals from Northwestern University set against a glowing DNA double helix on a purple background

Nominations open through Sept. 25 for Northwestern’s annual $250K Kimberly Prize in Biochemistry & Molecular Genetics, honoring a scientist whose biochemical, genetics, or molecular research shows outstanding achievement with significant impact on clinic & human health: tinyurl.com/ptu697bx

ORCID: Register, Use, Share - Tue, August 5 10:00 AM CDT at Online (Zoom) Prism: collect, share, and preserve the full spectrum of your work - Tue, August 5 11:00 AM CDT at Online (Zoom) Conducting a Systematic Review: Part 2 - Tools & Resources - Tue, August 5 12:00 PM CDT at Online (Zoom) Conducting a Scoping Review - Wed, August 6 12:00 PM CDT at Online (Zoom) Northwestern Elements - Thu, August 7 10:00 AM CDT at Online (Zoom) PubMed - Tue, August 12 12:00 PM CDT at Online (Zoom) EndNote - Wed, August 13 12:00 PM CDT at Online (Zoom) NIH Public Access Policy and Publication Management with MyNCBI - Thu, August 21 12:00 PM CDT at Online (Zoom) 10 Simple Rules for File Organization - Wed, August 27 10:00 AM CDT at Online (Zoom)

Happy August!🌻 Join us this month for our virtual class offerings. Register here: galter.northwestern.edu/classes

Cell Feature Implicated in Cancer Forms Differently than Previously Thought A team with Professor Krishna Shrinivas discovered how a landmark found in the nucleus of cells in many organ systems forms through a different mechanism than the well-established view, a revelation t...

A team co-led by Northwestern cell biologist Wilton Snead, PhD, discovered a new mechanism driving paraspeckle formation — challenging models of nuclear condensates and offering insight for future #cancer therapies, according to a recent study published in @pnas.org. tinyurl.com/j4t699zp

Successful Gene Editing Demonstrated for a Rare Neurodevelopmental Disorder - News Center Scientists have implemented a novel gene-editing approach that may be an effective treatment for alternating hemiplegia of childhood (AHC), a rare neurodevelopmental disorder in children, according…

A clinical breakthrough using a novel #GeneEditing approach may offer effective treatment for alternating hemiplegia of childhood (#AHC), a rare neurodevelopmental disorder, according to a recent study in Cell (@cp-cell.bsky.social).

Novel Molecular Mechanisms Inform Targeted Therapies for Chronic Kidney Disease - News Center A recent Northwestern Medicine study has identified novel molecular mechanisms by which genetic mutations in the PKD2 gene cause the most common type of polycystic kidney disease, according to…

A recent study from the DeCaen Lab has identified novel molecular mechanisms by which genetic mutations in the PKD2 gene cause the most common type of polycystic #KidneyDisease, according to findings in @pnas.org. #PKD

Novel Mechanism Reduces Epithelial Cell Damage and Loss - News Center Northwestern Medicine scientists have discovered a previously unknown process used by epithelial cells to alleviate epithelial tissue crowding and avoid cell damage and loss, according to a recent…

A new publication from the Brian Mitchell Lab reveals a novel mechanism epithelial cells use to alleviate tissue crowding, reducing cell damage and loss. Published in @natcomms.nature.com. @evesuva.bsky.social

Excited to share this preprint from my lab. We report a potent and site-specific inhibition of translation initiation by 2’O methylation.

It’s been a though year, but these discoveries keep us excited and motivated! #RNAsky #RNAbiology

Honored to be hosting Rylie Pancoast as an AES Bridge Summer Intern 🧠🧪 @nu-bsa.bsky.social @amepilepsysoc.bsky.social

You are invited to join the Center for Human Immunobiology with the Division of Pulmonary and Critical Care Medicine for the CHI Distinguished Lectureship Series. This will be our last Lecture of the academic year!

More Details: planitpurple.northwestern.edu/event/621548

Photo of Feng Yue, PhD, in a lab setting. Text on the left side of the image reads: "Feng Yue, PhD, was inducted into the 2025 class of the AIMBE College of Fellows."

Feng Yue, PhD, professor of Biochemistry and Molecular Genetics, has been inducted into the 2025 class of the American Institute for Medical and Biological Engineering (‪@aimbe-official.bsky.social‬) College of Fellows. tinyurl.com/2w256kex

Uncovering How Poxvirus Hijacks Host Proteins to Spread - News Center Northwestern Medicine scientists have uncovered new details about how poxvirus hijacks its host’s protein synthesis machinery to multiply and spread, according to a study published in Nature…

In a recent @natmicrobiol.nature.com study, scientists led by Derek Walsh, PhD, reveal how poxviruses — including deadly pathogens like #smallpox — hijack host protein synthesis to multiply and spread. tinyurl.com/ya7yukw4