Doryen Bubeck

Thanks @ccpem.bsky.social for an excellent workshop today showing @imperiallifesci.bsky.social what we can do with #doppio on our new computing cluster funded by @ukri.org

CryoET tomogram with the gap junction (green), ribosomes (cyan) and microtubules (pink)

In our latest preprint on bioRxiv, we present the in situ structure of
the human gap junction at 14 Å resolution using cryo-ET.

The structure provides a blueprint for investigating how connexin
regulation shapes intercellular communication in health and disease.

Our latest story describes the amazing evolutionary battle between malaria parasite and human. The parasite evolved RIFINs to bind inhibitory KIR receptors and suppress immune cell function while humans have activating KIR receptors to bind these RIFINs to kill parasites!

Thank you everyone who sponsored the @doryenbubeck.bsky.social Bubeck lab to run the CRUK Pretty Muddy Race for Life. The team raised over £1200!

#OurImperial

fundraise.cancerresearchuk.org/page/doryens...

Join us for our next #ConvergingOnCancer seminar where we'll explore these topics with:

➡️Prof @doryenbubeck.bsky.social‬ (@imperialsci.bsky.social‬)
➡️Dr @claudioalfieri.bsky.social‬ (@icr.ac.uk‬ )

📅 Thursday 5th June, 3-4pm
🖱️ For more information and how to register: bit.ly/3Z80SqS

⏰ Deadline approaching for postdoc position in my lab, Dunn School, University of Oxford.

We work on how the cell's antenna receives and transmits essential signals through motor protein driven transport.

❄️ Cryo-EM/ET, smTIRF, cell biology methods 🧪🔬

30/5/25 ➡️ tinyurl.com/KToropovaPDRA

Doryen's Race for Life I haven't met a single person whose life has not been touch by cancer. The current statistic is that 1 in 2 people will be diagnosed with cancer in their lifetime. As a scientist I know the significan...

Still time to sponsor @doryenbubeck.bsky.social who ran the Pretty Muddy Race for Life for Cancer Research UK this weekend! Congrats Doryen!

fundraise.cancerresearchuk.org/page/doryens...

Macrocyclic peptide inhibitors for CD59 receptor | Imperial News | Imperial College London A collaboration between the Tate, Bubeck and Kawamura groups has developed the first macrocyclic peptide inhibitors for cell-surface receptor CD59

Exciting progress in drug discovery - a cross-disciplinary team including @doryenbubeck.bsky.social, Tate and Kawamura researchers have developed the first macrocyclic peptide inhibitors for CD59 — a tricky cell-surface receptor often hijacked by bacteria.

www.imperial.ac.uk/news/263433/...

We are looking for a postdoctoral fellow to join us to explore telomerase regulation by histones. Please get in touch if this may interest you.

Great day collecting cryo SIM data @diamondlightsource.bsky.social

Thanks Nick! Looking forward to visiting TSL in May.

Honored to have been chosen for this year’s GlaxoSmithKline Award from @biochemsoc.bsky.social. A big thank you to lab members past and present @imperialsci.bsky.social and @erc.europa.eu @cruk-si.bsky.social @wellcometrust.bsky.social for supporting our work.

Did you miss the @doryenbubeck.bsky.social inaugural lecture last week or just fancy re-watching?! 😀

Join Doryen in the fascinating world of proteins, the "tiny machines" that drive cellular functions, using cryo electron microscopy.

www.youtube.com/live/H14PeFt...

#OurImperial

London FameLab Final Experience the excitement of the London FameLab Final! Enjoy engaging science talks as contestants compete for a place in the UK Final.

We're excited that Facilities Manager Sam Horrell has made it to the London Final of FameLab, a science outreach competition with 3 minutes to explain a scientific topic in an engaging way. The final is on 2 April and is free - please come & support Sam!

www.eventbrite.co.uk/e/london-fam...

YouTube video by Imperial College London Big questions, tiny machines

www.youtube.com/watch?v=H14P...

Karen Davies ‪Formerly of Electron Bio-Imaging Centre, Diamond Light Source, United Kingdom‬ - ‪‪Cited by 2,887‬‬ - ‪cryo-EM‬ - ‪tomography‬ - ‪method development‬ - ‪bioenergetics‬

Sad news about Karen Davies' passing.
Karen was an inspiration in bioenergetics and cryoET. Her pioneering postdoctoral work on ATP synthase and respiratory supercomplexes marked turning points in the field. I created Scholar profile to acknowledge her contribution
scholar.google.com/citations?hl...

Thank you so much! The demo was so much fun to do ☄️☄️☄️

Great live demonstration of how election microscopy works, and the signal to noise challenge in atomic imaging, at @doryenbubeck.bsky.social's inaugural lecture #imperialinaugural

Amazing inaugural lecture tonight from @doryenbubeck.bsky.social

Proteins scatter electrons, but the images are noisy...check out how an electron microscope works as showcased by our Head of Department @dandavis101.bsky.social 😄😃🔬

Big questions, tiny machines YouTube video by Imperial College London

Thanks so much @doryenbubeck.bsky.social for an amazing inaugural lecture tonight, 'Big Questions, Tiny Machines' nothing short of inspiring for our packed audience! 👩‍🏫

#OurImperial

Did you miss it?! No worries if so, as you can check out the recording below:

www.youtube.com/live/H14PeFt...

Dan, in white lab coat with a shield, sends of electrons being thrown at by an assembled mob of audience volunteers.

A highlight of Professor @doryenbubeck.bsky.social‘s inaugural lecture tonight was @dandavis101.bsky.social being pounded with electrons…

🎉 And that’s a wrap!

The Wellcome-MRC Cryo-EM in Structural Biology 2025 course in Leeds was a fantastic week of learning, hands-on training, and great discussions.

Huge thanks to our amazing instructors, speakers & enthusiastic participants for making it such a success! #CryoEM

Don't forget to come to Prof Doryen Bubeck's inaugural lecture, "Big Questions, Tiny Machines"! Open to all!!

📅 Wed, 12 March 2025

Understanding how pathogen proteins interact with human defence systems means we can develop new ways to prevent disease.

@doryenbubeck.bsky.social

#OurImperial

Really looking forward to this. Come along if you can!

🔬 Join us for Prof Doryen Bubeck's inaugural lecture, "Big Questions, Tiny Machines"

@doryenbubeck.bsky.social @imperiallifesci.bsky.social

📅 Wed, 12 March 2025

Discover how structural biology has changed the game when studying proteins & their role in immune responses 👉 bit.ly/4aHdABe

1) We have an exciting job opportunity in correlative bioimaging at B24 at @diamondlightsource.bsky.social applying cryo soft x-ray microscopy (cryoSXT) and super-resolution 3D structured illumination fluorescence Microscopy (CryoSIM)

Cryo-EM structure and evolutionary history of the conjugation surface exclusion protein TraT - Nature Communications Outer membrane protein TraT protects bacteria from secondary F plasmid conjugation. Here, the authors report cryo-EM structure of decameric cork-like TraT and its evolutionary history as a chromosomal gene that has been incorporated into multiple plasmid families.

Cryo-EM structure and evolutionary history of the conjugation surface exclusion protein TraT | Nature Communications https://www.nature.com/articles/s41467-025-55834-w

Reminder that @arianebriegel.bsky.social compiled a nice list of women in #cryoEM . I often get asked to recommend people and this is a great place to start 😀
briegel-lab.org/women-in-cry...

Many Congratulations to Dan for a well-deserved MBE!! @dandavis101.bsky.social
Read his books if you haven’t already. My favourite is the Beautiful Cure.

Congratulations to Dr Richard Zhou! And thanks to his lovely examiners @doryenbubeck.bsky.social and Yvonne Jones for giving him a really engaging viva. Watch out for his nice paper, coming soon. A proud supervisor.