Ali D. Güler

Therapeutic VEGFC treatment protects against traumatic brain injury-driven tauopathy pathogenesis @cp-cellreports.bsky.social
www.sciencedirect.com/science/arti...

Circadian variation in MGMT promoter methylation and expression predicts sensitivity to temozolomide in glioblastoma - Journal of Neuro-Oncology Purpose Recent studies show that glioblastoma (GBM) is more sensitive to temozolomide (TMZ) in the morning. In cells, inhibiting O6-Methylguanine-DNA-Methyltransferase (MGMT) abolished time-dependent ...

#Circadian #medicine tests if treatment timing can improve patient outcomes. This paper by @mariafelicita.bsky.social @oliviawalch.bsky.social et al considers #chronodiagnostics ...how the outcome of a standard test for glioblastoma differs with time of biopsy. link.springer.com/article/10.1...

Review of applications will begin in 5 days!

I have been trying to get this published as an op-ed, but I am going to post it here since I think it is timely in light of the "consent" extortion events.

Deafening Quiet from the Scientific Establishment

jeremymberg.github.io/jeremyberg.g...

1/14

Interested in a tenure track position teaching and doing research with undergrads at a PUI? We are looking for a broadly-defined microbiologist who can teach Med Micro and Immunology. Apply at universityofscrantonjobs.com/postings/8308. Pls share widely to feeds (& on twitter if you still tweet)! 🦠

Trump Is Shutting Down the War On Cancer

I am not a political pawn. I am a living, breathing human being who has dedicated her life to a scientific problem that I believe matters for human health. The article below tells our story; I hope you will read it and share it www.nytimes.com/2025/09/14/m...

Don't miss this opportunity to be our colleague! Very exciting initiative here at UVA!

Come be my colleague! Happy to answer any questions about what it's like living in Charlottesville and being in the department.

We welcome applicants working on:
• Neural circuits & plasticity
• Glia & brain interactions
• Behavioral genetics & genomics
…and more!
Join a highly interdisciplinary department with access to state-of-the-art imaging, genomics, metabolomics, and computing resources.

At UVA, you’ll be part of a vibrant, collaborative neuroscience community spanning Biology, Medicine, Engineering, Data Science & more... in beautiful Charlottesville, VA. 🌄
Apply today & help shape the future of neuroscience:
👉 apply.interfolio.com/172892

🚨 We’re hiring! 🧪 @uvabio.bsky.social
UVA Biology is recruiting multiple tenure-track Assistant Professors in neuroscience as part of a $75M Brain & Neuroscience Initiative. 🧠
Apply by Oct 15, 2025. Start Aug 2026.
👉 apply.interfolio.com/172892
#Neuroscience #FacultyJobs #NeuroJobs #Biology #UVA

At UVA, you’ll be part of a vibrant, collaborative neuroscience community spanning Biology, Medicine, Engineering, Data Science & more... in beautiful Charlottesville, VA. 🌄
Apply today & help shape the future of neuroscience:
👉 apply.interfolio.com/172892

We welcome applicants working on:
• Neural circuits & plasticity
• Glia & brain interactions
• Behavioral genetics & genomics
…and more!
Join a highly interdisciplinary department with access to state-of-the-art imaging, genomics, metabolomics, and computing resources.

🚨 We’re hiring! 🧪 @uvabio.bsky.social
UVA Biology is recruiting multiple tenure-track Assistant Professors in neuroscience as part of a $75M Brain & Neuroscience Initiative. 🧠
Apply by Oct 15, 2025. Start Aug 2026.
👉 apply.interfolio.com/172892
#Neuroscience #FacultyJobs #NeuroJobs #Biology #UVA

It is impossible to explain to civilians how it feels to finally, FINALLY, land a clearly within-payline NIH grant score and then have it go unfunded because of all this regime bullshit.

You all have my sympathies. Unfair doesn’t even begin to describe it.

GIP receptor agonism suppresses inflammation-induced aversion and food intake via distinct circuits https://www.biorxiv.org/content/10.1101/2025.08.12.669936v1

Sharing our newest study led by the incredibly talented @federicamosti.bsky.social investigating new molecular mechanisms of human brain development. We discover a human-specific enhancer HAR1984 that influences chromatin looping to promote cortical size and folding! www.biorxiv.org/cgi/content/...

These are the most challenging times for early-career scientists and engineers.

My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers.

We found 437 of them.

Download it freely here: research.jhu.edu/rdt/funding-...

My team has updated our free database of POSTDOC fellowships.

This database contains 286 entries. For each entry, we provide a link, short description, deadline, amount, and eligibility criteria.

Download this updated and expanded database here: research.jhu.edu/rdt/funding-...

🤣

The updated version of the database of PhD fellowships produced and maintained by my team can be downloaded by anyone here:

research.jhu.edu/rdt/funding-...

For each of the 187 fellowships, you will find a short description, deadline, $ amount, link, etc.

Good luck!

It doesn't matter if the Executive Order is illegal. The NIH has demonstrated consistently that it will follow orders from the OMB. Expect immediate action from the NIH on this order.

As I told you months ago, the old NIH is gone.

Pill Causes Major Weight Loss in Eli Lilly Trial’s Results

www.nytimes.com/2025/08/07/h...

Pill Causes Major Weight Loss in Eli Lilly Trial’s Results

www.nytimes.com/2025/08/07/h...

Pill Causes Major Weight Loss in Eli Lilly Trial’s Results The company said it planned to seek Food and Drug Administration approval for the drug, orforglipron, before the end of the year.

People who were overweight or had obesity lost a substantial amount of weight after taking a daily pill made by Eli Lilly, the company reported Wednesday. If the pill is approved by the FDA, it'll provide an alternative to weight-loss injectables like Ozempic.

‘It’s really, really bad right now’: NIH scientists dismayed by Trump cuts Researchers say scientific community is in state of whiplash and accuse president of trying to ‘destroy’ vital work

"What struck me was that many of my colleagues at universities [last week] were like, ‘Oh, my God, they’re stopping grants!’ And it seemed to activate people in a way that I hadn’t seen before.

Whereas a lot of us at NIH thought, ‘Oh, they just did another thing [to stop grants].’” 🧪

#JNeurosci: Stritzel et al. found that brief nighttime exposure to dim red light conditions widely used in rodent research caused circadian disruption and red light stimuli were detected by the rodent visual system. ‪@colorado.edu‬ @vulintus.com‬
https://doi.org/10.1523/JNEUROSCI.0157-25.2025

If they really had our backs, they would take steps RIGHT NOW to stop the NIH from continuing with the multi year mandate pushed by Vought and the OMB.

Low-dose metformin requires brain Rap1 for its antidiabetic action Metformin lowers blood glucose by inhibiting Rap1 in ventromedial hypothalamic neurons that regulate glucose balance.

Metformin, the first line drug for Type 2 diabetes, has been used for 60 years without a clearcut mechanism of action. It turns out it's not just reducing glucose output from the liver. Metformin also works via the brain www.science.org/doi/10.1126/...

Low-dose metformin requires brain Rap1 for its antidiabetic action Metformin lowers blood glucose by inhibiting Rap1 in ventromedial hypothalamic neurons that regulate glucose balance.

Houston researchers found that low-dose metformin needs Rap1 in the brain to lower blood sugar.

Without brain Rap1, metformin doesn’t work, but other diabetes drugs still do.

The ventromedial hypothalamus is the key control site.

www.science.org/doi/10.1126/...