Corynn Kasap MD PhD

We are excited about the potential for anti-CD70 CAR-Ts to make a difference for high-risk #myeloma patients

Special shout-out to our Junior Specialist Sanjana Prudhvi, who designed our Visual Abstract. We are lucky to work with such an amazing team, including everyone in the Wiita Lab @ucsfcancer.bsky.social and our collaborators. (10/10)

Finally, we developed a proof-of-principle dual-targeting CAR against both BCMA and CD70 as a potential strategy to avoid antigen escape–mediated resistance in #HRMM (9/10)

We also evaluated epigenetic regulation of CD70 in #myeloma, using a machine learning model to predict and then test key transcriptional regulators of surface expression (8/10)

While all anti-CD70 CARs demonstrated clear efficacy against myeloma cell line xenograft models in vivo, the CD27-based CAR showed remarkable >80-fold expansion‼️ versus scFv-based CARs, suggesting a highly favorable phenotype for clinical translation (7/10)

We then used the crystal structure of CD70 bound to its natural receptor CD27 to develop a structure-guided, optimized CD27-based CAR to compare to standard “scFv” based CAR, using frameworks containing either CD28 or 4-1BB costim domains. (6/10)

Analysis of paired tumor RNA sequencing data from
‪@themmrf.bsky.social‬ CoMMpass study, cell surface #proteomics, and flow cytometry revealed CD70 was present on primary #myeloma. CD70 transcript was strongly enriched in high risk genotypes t(4;14), gain 1q, and loss 1p (5/10)

...Samir Parekh at Icahn Mount Sinai, Stieglitz lab and the myeloma clinical group @ucsfcancer.bsky.social . Major support from Myeloma Solutions Fund, NIH NCI, and
UCSF Living Therapeutics Initiative (4/10)

This work was co-led by myself, Adila Izgutdina, and
@bonellpatinoe.bsky.social under mentorship of @apwiita.bsky.social, + collab w/ Ben Barwick and Larry Boise @winshipcancer.emory.edu, ‪@jdlicht.bsky.social,
‪@shanmugamlab.bsky.sociall, @kortemmelab.bsky.social, and... (3/10)

In this work we show CD70 is a novel CAR target enriched in #HRMM. We used structure-guided design to optimize a CD27-based anti-CD70 CAR-T that outperforms scFv-based CAR-Ts in preclinical efficacy studies. (2/10)

Excited to share our new manuscript, now published in Blood! BCMA #CART show impressive responses for #myeloma, but pts with high-risk cytogenetics relapse more quickly and are in urgent need of new therapies. Thread👇 (1/10) ashpublications.org/blood/articl...

Thrilled to share our new paper in Blood! We show that CD70 is upregulated in high-risk MM, and that a CD27-based anti-CD70 CAR-T design achieves >80-fold improved expansion in vivo. So honored to co–lead this work with @corynnkasap.bsky.social, Adila Izgutdina under
@apwiita.bsky.social mentorship

We did a thing. @standupforscience.bsky.social

It was so much work but worth it! San Francisco really showed up!
@standupforscience.bsky.social

Out of the lab and into the streets, researchers and doctors rally for science against Trump cuts Researchers, doctors, their patients and supporters are venturing out of labs, hospitals and offices across the country to stand up to what they call an attack on life-saving science by the Trump admi...

“Out of the lab and into the streets, researchers and doctors rally for science against Trump cuts” by @borenbears.bsky.social for @apnews.com. Read more here:

apnews.com/article/scie...

STAND UP FOR SCIENCE!✊🏽💪

Great turnout in #SanFrancisco to defend science from political attacks. Funding science is what actually makes America great vehicle for economic growth, advances in innovation, American leadership, upward mobility for Americans, and overall benefit to humanity.

Beautiful day and amazing turnout to hear keynote speaker and Nobel laureate Carolyn Bertozzi speak in San Francisco at today’s protest in defense of federal science funding #StandUpForScience2025 #StandUpForScience

Attendees at SF Stand Up for Science with signs

Sign that says Save Our Science

Nobel Prize winner @carolynbertozzi.bskyverified.social talking about how important science is and how we are in danger of losing decades worth of investment in science. Highlighting the danger to programs that gave her her start in science targeted for DEI & the cost of losing them

Thousands gather across U.S. in Stand Up for Science events Scientists rally across the country in response to layoffs and funding cuts ordered by the Trump administration

Breaking news: Thousands of researchers and their supporters, including recently fired federal workers, have gathered across the U.S. in response to layoffs and funding cuts ordered by the Trump administration. scim.ag/41zlPv4

I was bot involved in making any of the posters behind me but I agree with all of them.

A Capitol building with pro-science signs

#StandUpForScience Denver

#New: Huge crowd gathers for #StandUpForScience2025 rally in San Francisco:

San Francisco really showed up for #standupforscience2025!! Making me proud, Bay Area.
🥼🌁🌍

So happy to see so many people who want to support the fight to preserve science funding at today’s #StandUpForScience in SF @standupforscience.bsky.social

Amazing turnout at today’s #StandUpForScience in San Francisco

List of Stand Up for Science events—official events in red, solidarity events in blue.

SO MANY STAND UP FOR SCIENCE EVENTS TO CHOOSE FROM—153 and COUNTING!

To get more information on our local events and to register your own, head to www.standupforscience2025.org/local-event-information/ ☀️⬇️🌎

Official SUFS Events These are the state capitals and major cities (alphabetized by state) hosting official Stand Up for Science events. If your city is listed below, a confirmed site leader—backed by our core team—is …

Stand Up for Science event in SF is March 7 1-3pm Civic Center Plaza. Other official events listed here: standupforscience2025.org/official-eve...

NIH funding of basic + translational science trainees is critical for advancing the standard of care for cancer patients. I could not have done the work I did, and want to continue to do, without the 9+ years of NIH support I have received.

Federal Register hold makes ‘end run’ around court pause on NIH funding freeze NIH-related updates to the Federal Register, which are required for the scheduling of study sections and advisory councils, are on hold indefinitely, according to an email reviewed by <i>The Transmitt...

NIH funding blocked: If study sections and review councils don’t meet, then grants are not awarded. “U.S. National Institutes of Health-related updates to the Federal Register… are on hold.” www.thetransmitter.org/funding/fede...

California Stand Up for Science, March 7 in Sacramento - it’s happening. Spread the word. standupforscience2025.org/sacramento-ca/