Molecular Cell Biology and Immunology Lab

Lotte de Winde standing in front of her title slide « Lymphoma on a chip model reveals that lymph node stromal cells promote B cell lymphoma survival and migration »

On the 1st day of the @cancercenterams.bsky.social annual conference Lotte De Winde presented her recently published data on the development of lymphoma-on-a-chip model to study the role of fibroblasts in this pathology! You can find the publication here doi.org/10.1016/j.mt...

Today marks the 44th anniversary of the publication in the MMWR of a new syndrome that we now know as AIDS www.cdc.gov/mmwr/preview... (MMWR 1981;30:250--2). Much progress since then but much remains to be done.

### PhD position alert ###

Please repost!

I'm excited to announce a new *PhD position* within our group.

We are looking for a super-motivated candidate with a solid basis in wet- and dry-lab research. Apply now & make sure to include all docs!

werkenbijprinsesmaximacentrum.nl/en/vacancy/p...

The next single cell club is happening today!!

Come join us!

Vacatures - Junior Postdoc Inhalable vaccine - Amsterdam UMC Investigate whether local application in the lung can further enhance the efficacy of nanovaccines in generating lung-resident memory T cells.

We’re looking for a Junior Postdoc to join our growing team at Amsterdam UMC, working on inhalable nanovaccines to activate lung immunity especially resident memory T cells (Trm) against cancer.

More info here👇
🔗 werkenbij.amsterdamumc.org/en/vacatures...
@mcbi-amsumc.bsky.social

Our own Yvette van Kooyk will be presenting! See you there?

For the next session of our Single Cell club we will host Rosalia Franco Fernandez @amsterdamumc.bsky.social to discuss CD8 responses in gastric cancer metastasis!

Altogether, this model highlights the potential of lymphoma-on-chip models to study the role of lymph node stromal cells in cancer development and progression. Stay tuned for updates on this project!

(2) They also potentiated the ability of lymphoma cells to enhance lymphatic vessel permeability, although they did not affect permeability on their own.

In addition, to survival this model hint at a role of FRCs in contributing to lymphoma cell metastasis in two different ways. (1) They promoted directional migration of lymphoma cells towards the lymphatic vessels.

The addition of primary FRCs in the model improved the viability of the lymphoma cells, which was linked to increased production of interleukin-6, a known survival factor for hematological cancer cells.

Immunofluorescence picture of the lymphoma-on-chip including staining of lymphatic vesell cells (red, CD31), primary fibroblasts (green, vimentin), and lymphoma cells (blue, "DLBCL").

3D-rendering of the lymphoma-on-chip including staining of lymphatic vesell cells (red, CD31), primary fibroblasts (green, vimentin), and lymphoma cells (blue).

They describe the construction of a lymphatic vessel (red) surrounded by lymphoma cells (DLBCL, blue) and primary fibroblastic reticular cells (FRCs, green) in a hydrogel.

Lymphoma-on-chip model reveals that lymph node stromal cells promote diffuse large B-cell lymphoma survival and migration Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive B-cell non-Hodgkin lymphoma, often developing resistance to current treatments. De…

MCBI researchers led by Lotte de Winde developed a lymphome-on-chip model that include lymph node stromal cells (fibroblastic reticular cells), thereby offering a new model to study these cells in the development and progression of lymphoma!
tinyurl.com/2mads7kr

On the second day of the conference, Eleonora Nardini presented her PhD project aiming at understanding how peptide sialylation affects the adaptive response in hemophilia A. #glycotime

In the mucosal immunology session Myrthe van Delft presented her research on the novel mice model to study the role of IgA in vivo. The project was performed together with the Lambrecht group @viblifesciences.bsky.social

During the keynote, Elga de Vries presented her team’s work on the immune changes associated with the neurodegenerative diseases #MultipleSclerosis and dementia #Alzheimersdisease. Some of the presented results have been discussed there doi.org/10.7554/eLif... rdcu.be/d3b9Q

Sofía Ibánez-Molero in front of her title slide ‘Capturing tumor-immune cell interactions’.

Today is the beginning of the Dutch Society for Immunology Winterschool! Our department is well represented, starting with Sofía Ibáñez-Molero who presented past and future work on investigating the direct interaction between tumor cells and immune cells!

Hi! Could you add us to the starter pack too, please? :)

Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️

So how can we ever achieve #gender #equality?

We discuss various strategies in this #Cell Commentary

#WomeninSTEM

www.cell.com/cell/fulltex...
🧵 1/

Hello Lucille! Could you add us to this starter pack, please?

Hi Jon, could you add us if still possible? :)

Hi! We’re late to the party but could you add us?

We’re late to the party but could you add us too?