Corcoran Lab

Elucidating the coordination of RNA processing using short-read and long-read RNA-sequencing methods Nature Reviews Molecular Cell Biology, Published online: 06 October 2025; doi:10.1038/s41580-025-00895-4Co-transcriptional mRNA maturation is a complex, multistep process. This Review focuses on how the development of long-read sequencing methods enabled investigating the timing, coordination and outcomes of alternative uses of transcription start sites, splice sites and polyadenylation sites and their disease implications.

New Online! Elucidating the coordination of RNA processing using short-read and long-read RNA-sequencing methods

This is an incredibly moving thread.

Protein-based tools for the detection and characterisation of Oropouche virus infection Oropouche fever is a neglected tropical viral disease endemic to Latin America and the Caribbean. Oropouche fever is caused by Oropouche virus (OROV), an orthobunyavirus with a tri-segmented (-)ssRNA ...

The world may be horrible at the moment, but I am thrilled to share a preprint on our work to develop novel diagnostics and tools to study #Oropouche virus, (probably) the most important virus that you’ve never heard of:
doi.org/10.1101/2025...
Bluetorial follows 🟦🧵

A truncated SARS-CoV-2 nucleocapsid protein enhances virus fitness by evading antiviral responses Viruses face a selective pressure to evade cellular antiviral responses to control the outcome of an infection. However, due to their limited genome size, viruses must adopt unique strategies to confr...

@rorymulloy.bsky.social et al illuminate mechanism rewarding evolution of novel transcriptional start sites in SARS-CoV-2 during its adaptation to humans 👀. From: @corcoranlab.bsky.social www.biorxiv.org/content/10.1...

Pre-print is up! SARS-2 produces a truncated N protein to antagonize multiple antiviral pathways. A very collaborative project in the @corcoranlab.bsky.social with @nogasharlin.bsky.social, Danyel Evseev, and Max Bui-Marinos, and of course the boss Jenn Corcoran

www.biorxiv.org/content/10.1...

thanks @ngrandvaux.bsky.social ! Fingers crossed on submission!

A truncated SARS-CoV-2 nucleocapsid protein enhances virus fitness by evading antiviral responses Viruses face a selective pressure to evade cellular antiviral responses to control the outcome of an infection. However, due to their limited genome size, viruses must adopt unique strategies to confr...

Our newest work reveals that SARS-CoV-2 evolved to produce a truncated version of its N protein to antagonize antiviral responses. This 'mini' N, called N*M210, sequesters dsRNA, blocks interferon activation, defeats RNaseL & disassembles stress granules and p-bodies. www.biorxiv.org/content/10.1...