Gaowen Liu's Avatar

Gaowen Liu

@gaowen.bsky.social

PI in SIAT, big fan of yeast genome evolution research

17 Followers  |  48 Following  |  5 Posts  |  Joined: 28.09.2025  |  1.5873

Latest posts by gaowen.bsky.social on Bluesky

Super excited that this story by @borissieber.bsky.social is now on BioRxiv!

For decades, we thought there was no MAPK scaffold for the ERK-like cascade that promotes sexual reproduction in fission yeast ... until Boris found it !

See the thread 👇 and enjoy the paper!

doi.org/10.1101/2025...

25.09.2025 19:48 — 👍 38    🔁 17    💬 1    📌 1
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During the course of evolution, we found a case of genetic assimilation at the telomeric end of chromosome I: a subtelomeric deletion triggered silencing that stabilized previously unstable, oscillatory fusion efficiency—an adaptation shaped by intertwined genomic and epigenetic changes.

28.09.2025 12:54 — 👍 2    🔁 0    💬 0    📌 0
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Our data trace a negative correlation between mating efficiency and proliferation, capturing a classic life-history trade-off in action.

28.09.2025 12:48 — 👍 1    🔁 0    💬 0    📌 0
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We pushed yeast through 18 cycles of mitosis–meiosis by painstaking tetrad dissection to enforce selection. Why 18? Not a lucky Chinese number—COVID shut us down at that time😂

28.09.2025 12:43 — 👍 2    🔁 0    💬 0    📌 0

Thrilled to finally share this seven-year story—a journey that began during my postdoc in Sophie’s lab.
@sophiemartinlab.bsky.social and continued for four more years as I built my own lab in Shenzhen.

28.09.2025 12:34 — 👍 2    🔁 0    💬 0    📌 0
Sex or growth? Life must continually balance these strategies. We forced yeast to choose and captured the trade-off in real time. Evolution rewired existing regulators and fixed them through genetic assimilation, creating specialists for sex at the cost of growth. https://www.biorxiv.org/cgi/content/short/2025.09.26.678705v1 Thrilled to finally share this seven-year story—a journey that began during my postdoc in Sophie’s lab and continued for four more years as I built my own lab in Shenzhen.

Sex or growth? Life must continually balance these strategies. We forced yeast to choose and captured the trade-off in real time. Evolution rewired existing regulators and fixed them through genetic assimilation, creating specialists for sex at the cost of growth. https://www.biorxiv.org/cgi/content/short/2025.09.26.678705v1 Thrilled to finally share this seven-year story—a journey that began during my postdoc in Sophie’s lab and continued for four more years as I built my own lab in Shenzhen.

Sex or growth? Life must continually balance these strategies. We forced yeast to choose and captured the trade-off in real time. Evolution rewired existing regulators and fixed them through genetic assimilation, creating specialists for sex at the cost of growth.
www.biorxiv.org/cgi/content/...

28.09.2025 12:29 — 👍 33    🔁 14    💬 4    📌 1

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