According to Alphafold3 predictions and homology modeling, the Mpc complex is composed of an octameric lipoprotein MpcA anchored at the outer membrane, interacting with a hexameric tunnel-like MpcD, itself associated with an inner membrane complex comprising MpcE and MpcF ATPase. Absence of the Mpc complex modifies the lipid composition of outer membrane vesicles, suggesting that Mpc could be involved in lipid transport between inner and outer membrane.
Great work by Adélie Lannoy on Brucella abortus, just published in The EMBO Journal www.embopress.org/doi/full/10..... Thanks to fantastic collaborators! An enigmatic, perhaps ancestral, protein complex predicted as a tunnel-like structure between membranes. Crucial for survival in macrophages
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