Alexandra Colin

Microtubules: the architect of muscles. Watch how microtubules transport mitochondria in proximity to energy consuming sarcomeres in muscles of flies and mice. @jeromeavellaneda.bsky.social @nunoluis.bsky.social @ibdm.bsky.social with @gomeslabo.bsky.social www.sciencedirect.com/science/arti...

We have used many microwells to confine biochemical reactions in our recent studies. We wanted to share the protocol for preparing and characterizing microwells; this protocol is now published here : www.frontiersin.org/journals/cel...

@manuelthery.bsky.social @lblanchoin.bsky.social

#science 🧬 | Non, ce ne sont ni les slips de Superman, ni ceux de Walter White dans Breaking Bad.

C’est une cellule ... et la même photographiée 36 fois.
Sensation, adaptation, mémoire… la cellule est plus futée qu’on ne le croit 🤯.

Pour en savoir plus 👉 youtu.be/dX4rDXLJAdI

We also give examples of imaging and functionalization to study actin-related processes.

We detail the equipment and protocol for microwell manufacture, as well as characterization and quality control.

We have used many microwells to confine biochemical reactions in our recent studies. We wanted to share the protocol for preparing and characterizing microwells; this protocol is now published here : www.frontiersin.org/journals/cel...

@manuelthery.bsky.social @lblanchoin.bsky.social

🔬 From JCB’s July issue (rupress.org/jcb/issue/22...): a PtK2 cell plated on a micropattern and injected with low doses of soluble actin (orange) and tubulin (blue) in order to generate speckles along the corresponding filaments. From @manuelthery.bsky.social group (rupress.org/jcb/article/...).

this focused issue includes a great method by @alexandra-colin.bsky.social to make closed microwell in order to encapsulate your favorite reconstitution mix in compartments of controled size and shape. 🔴🟥🔻❤️

Frontiers | Reconstitution Methods in Cell Biology Reconstitution of cellular phenomena is a powerful approach for investigating the biochemical and biophysical processes that sustain life. Cell-free reconsti...

Interested in reconstitution methods? Love cell biology? Check out the accepted manuscripts in our Research Topic on Reconstitution Methods in Cell Biology! We are still open for submissions so if you're writing something exciting this summer, send it here: www.frontiersin.org/research-top...

Want to brush up your French? Check the summary of our work with @stefvass.bsky.social, “Plongée au cœur de l'endocytose axonale”, just out in the June issue of Médecine/Science! Open access here: www.medecinesciences.org/fr/articles/...
And we got the cover 😎

Come and Join our Dpt in Beautiful #Geneva !

We are looking for a #Microscopy & #Image #Analysis expert to help all of us at the Dpt.

Registration and abstract submission for the 2025 SFP Physics & Life days are now open!
The meeting will be held on October 2-3 at the Institute Jacques Monod, Paris. Deadline: September 5.
phys-life-2025.sciencesconf.org?lang=en
@sfp-physique.bsky.social

@ijmonod.bsky.social

Evolutionary repurposing of a DNA segregation machinery into a cytoskeletal system controlling cyanobacterial cell shape Bacteria, despite their diversity, use conserved cytoskeletal systems for their intracellular organization. In unicellular bacteria, the ParMRC DNA partitioning apparatus is well known for forming act...

One of the most exciting discoveries from our lab so far is now online as a preprint!

Read a story on how the ParMR and Min systems started to collaborate to create the CorMR cytoskeleton, which now controls cell shape in multicellular cyanobacteria:
www.biorxiv.org/content/10.1...

Just out: we used SReD to measure the periodicity of spectrin rings along axons, finely capturing the effect of actin depolymerization. This and many more applications ➡️ www.nature.com/articles/s41...

Another great collab with @henriqueslab.bsky.social, congrats @afonsomendes92.bsky.social et al 🙏

AML patient blasts exhibit polarization defects upon interaction with bone marrow stromal cells.

www.embopress.org/doi/full/10....

Work by Manuel Thery @manuelthery.bsky.social @institut-leucemie.bsky.social and co-workers.

Exciting news: our Board of Trustees has appointed @monicabettencourt.bsky.social as the CRG's new Director. Prof Bettencourt-Dias is expected to take up the post in 2026, replacing Dr. Luis Serrano, who will continue to maintain a research group at the institute.
www.crg.eu/en/news/moni...

Les membres du Conseil scientifique de l'ENS-PSL partagent la vive inquiétude des personnels d'@universcience.bsky.social sur le devenir du @palaisdecouverte.bsky.social et s'associent à la pétition en cours.

En savoir plus 👉 https://bit.pulse.ly/b1pitkbaaa

A picture of 3 rows of people on steps at the MRC LMB. From left to right - top row: Akaash, Vic, Lara - Middle row: Kerrie, Manu, Paddy - bottom row: Meg and Julie

🚨 JOB ALERT 🚨
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...

#STEMCareers #ResearchJobs

🔬 Vous souhaitez en savoir plus sur les médaillés 2025 de CNRS Biologie ?

📅 Rendez-vous chaque jour pour découvrir deux portraits de nos lauréats : leur parcours, leurs travaux, leur passion pour la recherche ! ⤵️

Merci Adrien !

Merci Marie Emilie :)

Merci Stéphane !

[ #TalentsCNRS ]🥉

Simplifier pour mieux comprendre le vivant🔬

Au LPCV, @alexandra-colin.bsky.social étudie l’organisation du cytosquelette d’actine sur des systèmes biomimétiques.

Ses recherches sur ces mécanismes clés de la cellule lui valent la médaille de bronze 2025 du @cnrs.fr 👏

The 2025 @cnrs.fr medal are out! Bronze medals for early career researchers: congrats to Aurélie Tchoghandjian at our institute @inp-marseille.bsky.social, and to @alexandra-colin.bsky.social who was nominated by the Cell biology section 🎉

Thank you @christlet.bsky.social and thanks to the the Cell Biology section for the nomination !

Cell state-specific cytoplasmic density controls spindle architecture and scaling Nature Cell Biology - Kletter et al. show that cell state-specific cytoplasmic density controls spindle architecture and scaling in neural differentiation, suggesting that the physical properties...

✨Thanks to amazing students @tobiaskletter.bsky.social, postdocs @biswashere.bsky.social & collaborators @vasilyzaburdaev.bsky.social‬ & ALMF @embl.org ✨

👉Cytoplasmic material properties control spindle architecture and scaling 👉 out today @natcellbio.nature.com rdcu.be/eqPr8

Proteostasis in cellular dormancy: lessons from yeast to oocytes Cellular dormancy is characterized by a prolonged, reversible cell cycle arrest and absence of growth. Dormancy allows organisms to endure unfavorable…

How do dormant cells keep their proteostasis in check?
@gzaffagnini.bsky.social & our PhD student Stephanie Rosswag take a deep dive in our featured review @cp-trendsbiochem.bsky.social
Don’t miss it! - EB
www.sciencedirect.com/science/arti...

Save the date poster of the Physics & Life days, division of the French Physical Society.

Save the date for the 3rd edition of the Physics & Life days, division of the French Physical Society, October 2-3 at the Institute Jacques Monod, Paris.
More info coming soon!
Co-organised with Silvia Grigolon & Morgan Chabanon.
@sfp-physique.bsky.social @ijmonod.bsky.social

We have two open Master’s internship projects for the 2025/2026 academic year in our lab! 🔬🧬

You can apply directly through the BIST website: mmres.bist.eu/research-pro...

We’re looking forward to hearing from you! 👋

@crg.eu @prbb.org @upf.edu

We wrote a review for the Biochemical Journal on the importance of using macroscopic reconstructions at the network level to better understand key issues related to the actin cytoskeleton: portlandpress.com/biochemj/art...