Eva Nowack

Spatial Proteomics Workshop for Protists

(see more in thread below)

Registration
Early Bird Monday 22nd June 2026.
Regular Monday 10th August 2026.
There will be a conference dinner on day 1. To register visit protistology.org.uk/autumn-meeti...

New AI tool “Helixer” identifies genes in newly sequenced organisms. Helixer identifies genes directly from DNA sequences.

Developed by team around @usadellab.bsky.social @fz-juelich.de, @apmweber.bsky.social , @sebtriesch.bsky.social @hhu.de et al. www.fz-juelich.de/en/news/arch...

Reminder with <2 weeks to deadline:

Short graphical abstract summarizing key facts about Angomonas: its habitat in the digestive tract of insects; the cellular organization of the flagellate containing a single cytoplasmic endsymbiont with associated glycosomes; synchronized cell cycles of host and endosymbiont; the discovery of endosymbiont-targeted host proteins (ETPs) by mass spectrometry; differential subcellular localization of the ETPs; and the endosymbiont division machinery of dual genetic origin.

The symbiont-harboring trypanosomatid Angomonas deanei is Parasite of the Month. 🙂
authors.elsevier.com/sd/article/S...

Save the date, please RT:

Looking forward to an exciting International Symposium @spp2330.bsky.social "New concepts in prokaryotic virus-host interactions".

October 5-7, 2026; Harnack-Haus Berlin (Germany).

@dfg.de @hhu.de @fz-juelich.de

Postdoc (m/f/d) in Endosymbiosis Research

📢Postdoc position available!🧪🧫🧬
Our group is seeking a motivated researcher to investigate the molecular mechanisms driving host–endosymbiont interactions.
Full details & application: karriere.hhu.de//index.php?a....
Please help us get the word out!

Thanks, Khaled! We don't know how it works. 🙈 Junctions would be one possibility.

Applause to Victoria Klimenko and huge thanks to @sander1507.bsky.social and the whole HHU Center for Structural Studies team for an amazing collaboration!🥳🥳🥳 (2/2)

crTP X-ray structure

✨X-ray crystallography reveals surprising twist in how proteins enter the unique photosynthetic organelles of Paulinella. The chromatophore targeting peptide (crTP) folds into a 3D structure, hinting that folded proteins cross peptidoglycan and inner membrane. (1/2)
academic.oup.com/plphys/artic...

Pretty excited to share our new preprint!
Non-photosynthetic Plastid Replacement by a Primary Plastid in the Making
www.biorxiv.org/content/10.1...

In Angomonas, the host and endosymbiont divide in sync. We discovered that ETP2 helps recruit the dynamin-like protein ETP9 to the symbiont division site, revealing a new piece of the host-encoded machinery controlling endosymbiont division.
Beautiful artwork by @anaymaurya.bsky.social 2/2

Out today: New nucleus-encoded component of the endosymbiont division machinery identified in the trypanosomatid Angomonas deanei.
Congrats @anaymaurya.bsky.social and @rudycadenabioevo.bsky.social!!!🎉🎉🎉 1/2
journals.asm.org/doi/10.1128/...

The cellular mechanics of symbiosis: sensing friend from foe

🚨 Save the date! Thrilled to be co-organizing the next iteration of the @embl.org Symposium on the Cellular Mechanics of Symbiosis (📅 March 17-20), w/ @floravincent.bsky.social, @hassansalem.bsky.social & Tom Richards.
www.embl.org/about/info/c...
#EESSymbiosis #Symbiosis #SymbioSky #MicroSky 🦠

Congratulations, @messorensen.bsky.social!

A genomic catalog of Earth’s bacterial and archaeal symbionts Microbial symbiosis drives the functional and phylogenomic diversification of life on Earth, yet remains underexplored due to culturing challenges. This study employed machine learning (ML) to predict...

Interesting AI read. 15-23% of uncultivated microbes may engage in symbiotic relationships.

www.biorxiv.org/content/10.1...

By sidestepping the complexities of polycistronic transcription (typical for trypanosomatids like Angomonas) Lena’s new system lays the groundwork for a long-awaited conditional expression platform which will be a game changer for dissecting host-symbiont molecular interactions in real time.

T7 RNA polymerase-based gene expression from a transcriptionally silent rDNA spacer in the endosymbiont-harboring trypanosomatid Angomonas deanei Eukaryotic life has been shaped fundamentally by the integration of bacterial endosymbionts. The trypanosomatid Angomonas deanei that contains a β-proteobacterial endosymbiont, represents an emerging ...

Excited to share that our T7 RNA polymerase-based expression system brings a new level of versatility to Angomonas deanei as a model for studying endosymbiosis!
doi.org/10.1371/jour...

Fantastic news! Congrats!!!🎉

The Nowack lab temporary tattoos have arrived! Time to decide if you're team Paulinella or team Angomonas...

New vacancy in my team!

PhD student position on microbial genome evolution, focusing on the evolutionary principles underlying bacterial genome architecture.

Please repost and share with talented MSc students in #evobio, bioinformatics or related :)

www.uu.nl/en/organisat...

#MEvoSky #MicroSky

A gatekeeper for gene transfers - Nature Plants Large-scale genetic screening for plastid-to-nucleus gene transfers identifies that fast double-strand break repair functions as a key barrier for nuclear integration of organellar DNA and provides in...

With their clever setup to visualize ongoing endosymbiotic gene transfers (EGTs), Enrique Gonzalez-Duran, Ralph Bock and team reveal how double-strand break repair limits excessive EGT. Check out their new Nature Plants paper and my News and Views summary! www.nature.com/articles/s41...

If interested in developing a proposal around microbial endosymbionts in protists (Paulinella, Angomonas or other systems), contact me by PM or email. (2/2)

Interested in joining Heinrich Heine University Düsseldorf for a 2-year postdoc project? Next week (May 6-7) the popular HHU Marie S. Curie Master Class takes place again, an online event supporting you to develop a compelling proposal for the MSCA Postdoctoral Fellowship program. (1/2)

Join the GMI as a Junior Group Leader! The GMI is seeking a talented scientist to lead an independent research group, addressing fundamental questions in molecular plant biology. More information is below.

Credit: Margot Riggi (@margotriggi.bsky.social), Max-Planck Institute of Biochemistry (@mpibiochem.bsky.social)

Asgard archaea have actin - but what about microtubules? Where do they come from? 🧐 Our new paper www.cell.com/cell/fulltex... by @xujwet.bsky.social & @florianwollweber.bsky.social, in collaboration with the Schleper & Wieczorek labs, describes tiny Asgard microtubules! #TeamTomo #ArchaeaSky 1/6

Thank you!😊

Send your 'friend' over! I'll be happy to discuss!😆

The host-encoded dynamin-like protein ETP9 forms a contractile ring around the endosymbiont. ETP9 knock down results in division-impaired, filamentous endosymbionts before cells eventually die. 2/2

Angomonas deanei with flourescent-labeled nucleus and endosymbiont. ETP9 localizes at the endosymbiont division site.

Out today: Exciting intermediate between endosymbiont and organelle identified! Endosymbionts in Angomonas deanei lost nearly all bacterial cell division genes. Instead, we identified a host-encoded protein, ETP9, that became specialized for endosymbiont division. 1/2
www.science.org/doi/10.1126/...