LabSoap

Tumor-derived arachidonic acid reprograms neutrophils to promote immune suppression and therapy resistance in triple-negative breast cancer How tumor cells overcome anti-tumor immune responses and drive cancer recurrence is not well understood. Yu et al. demonstrate how therapy-resistant breast cancer cells synthesize and secrete arachido...

This week #JournalClub from @LabSoap @cp-immunity.bsky.social #lipid #neutrophils #TNBC #breastcancer #resistance www.cell.com/immunity/abs...

Meningeal blood vessel blockage enhances anti-glioblastoma immunity Meningeal blood vessel blockage enhances anti-tumor immunity against GBM in preclinical models by expanding dural resident border-associated macrophages, which are equipped with an elevated antigen-pr...

This week #JournalClub @labsoap.bsky.social @cellpress.bsky.social #glioblastoma #immune_responses #meningeal_vessels www.cell.com/cell/abstrac...

Platelet-derived integrin- and tetraspanin-enriched tethers exacerbate severe inflammation Platelet integrin αIIbβ3 is essential for hemostasis, thrombosis, and inflammation. We found that ligation of αIIbβ3 by von Willebrand factor or fibrin under flow triggered its accumulation in plasma ...

This week #JournalClub @labsoap.bsky.social @nature.com #integrin #tetraspanin #migration www.science.org/doi/10.1126/...

IDH-mutant gliomas arise from glial progenitor cells harboring the initial driver mutation Identifying the cell of origin that harbors an initial driver mutation is key to understanding tumor evolution and for the development of new treatments. For isocitrate dehydrogenase (IDH)–mutant glio...

This week #JournalClub @labsoap.bsky.social @science.org #glioblastoma #IDH1 www.science.org/doi/10.1126/...

Secretome translation shaped by lysosomes and lunapark-marked ER junctions - Nature Live-cell imaging of mRNA encoding secretome proteins and translated nascent peptide markers show that secretome translation occurs at endoplasmic reticulum junctions near lysosomes, requires lun...

This week #JournalClub @labsoap.bsky.social #lysosomes #ER #secretion @nature.com www.nature.com/articles/s41...

This week #JournalClub @labsoap.bsky.social @nature.com #celldeath #plasmamembrane #rupture #MLKL #necroptosis www.nature.com/articles/s41...

Microbial signals in primary and metastatic brain tumors - Nature Medicine A combination of high-resolution spatial imaging, spatial proteomics and transcriptional data reveals sparse and heterogeneous bacterial signals in gliomas and brain metastases.

This week #JournalClub @labsoap.bsky.social #glioblastoma #microbiota @natureportfolio.nature.com www.nature.com/articles/s41...

This week no #JournalClub @LabSOAP - it's #SOAPosium celebrating a decade in #Nantes 🎂🎁🎈🎄⛄

Membrane potential mediates the cellular response to mechanical pressure Mechanical forces influence cellular decisions to grow, die, or differentiate, through largely mysterious mechanisms. Separately, changes in resting m…

This week #JournalClub @cellpress.bsky.social #membrane #pressure #Hippo #density www.sciencedirect.com/science/arti...

From Mechanisms to Therapy: Exploring the Role of Ferroptosis in Cervical Cancer Transformation and Treatment This review mainly discusses the role of ferroptosis in cervical cancer from four aspects: underlying mechanisms, stage-specific sensitivity, ferroptosis-related targets and biomarkers, and clinical ...

Just published !

onlinelibrary.wiley.com/doi/10.1111/...

Strain‐Dependent Immune Signaling by Small Extracellular Vesicles Derived From Trypanosoma cruzi‐Infected Macrophages Chagas disease, caused by Trypanosoma cruzi, remains a major treatment challenge due to variations in host immunity and parasite strains. We found that small extracellular vesicles (EVs) from infecte...

Just published !

onlinelibrary.wiley.com/doi/10.1111/...

Just Published!

Spatiotemporal Analysis of Glucagon Secretory Granule Dynamics - Ghignoli - 2025 - Traffic - Wiley Online Library onlinelibrary.wiley.com/doi/abs/10.1...

Just Published !

Virion Associated Importin Subunit Beta‐1 Augments Nuclear Import of HIV‐1 Pre‐Integration Complex - Yandrapally - 2025 - Traffic - Wiley Online Library onlinelibrary.wiley.com/doi/10.1111/...

Beyond the Secretory Pathway: New Insights Into Protein Release While proteins bearing N-terminal signal or leader sequences are secreted via the ER-Golgi-plasma membrane axis of the conventional secretion pathway, many cytosolic proteins lacking signaling sequen...

Just Published !

onlinelibrary.wiley.com/doi/10.1111/...

The Role of Small Extracellular Vesicles in Tumor Development and the Prospect of Targeted Therapy Mechanisms of sEV uptake:① Membrane fusion.② Endocytosis.③ Receptor-ligand interaction.

Just Published !

onlinelibrary.wiley.com/doi/10.1111/...

Creative experiences and brain clocks - Nature Communications Creative experiences such as dance, music, drawing, and strategy video games might preserve brain health. The authors show that regular practice or short training in these activities is linked to brai...

This week #JournalClub @labsoap.bsky.social @nature.com www.nature.com/articles/s41...

LYVAC/PDZD8 is a lysosomal vacuolator Lysosomal vacuolation is commonly found in many pathophysiological conditions, but its molecular mechanisms and functions remain largely unknown. Here, we show that the endoplasmic reticulum (ER)–anch...

This week #JournalClub @labsoap.bsky.social @science.org #LYVAC #vacuole #lysosome www.science.org/doi/10.1126/...

Predicting protein-protein interactions in the human proteome Protein-protein interactions (PPIs) are essential for biological function. Coevolutionary analysis and deep-learning (DL)–based protein structure prediction have enabled comprehensive PPI identificati...

This week #JournalClub @labsoap.bsky.social #proteome #AIscience www.science.org/doi/10.1126/...

@labsoap.bsky.social back from #Turku #0carbon #greencity #Finland for a very neat and excellent meeting on #braintumor #glioblastoma @fibtra.bsky.social

MTAP deficiency confers resistance to cytosolic nucleic acid sensing and STING agonists Cytosolic nucleic acid–sensing pathways are potential targets for cancer immunotherapy. Although stimulator of interferon genes (STING) agonists have shown substantial antitumor effects in animal mode...

This week #JournalClub @labsoap.bsky.social www.science.org/doi/10.1126/... #inflammation #STING #sensing @science.org

This week #JournalClub @labsoap.bsky.social #DNArepair #cGAS #STING @science.org #molerat 🐀 www.science.org/doi/10.1126/...

This week #journalclub @labsoap.bsky.social @naturemetabolism.bsky.social @agostinislab.bsky.social #Lysosome #ferroptosis #mitochondria www.nature.com/articles/s42...

This week #JournalClub @labsoap.bsky.social #Immunotherapy #resistance #cancerneuroscience @nature.com www.nature.com/articles/s41...

Axonal injury is a targetable driver of glioblastoma progression - Nature Axonal injury, induced in the white matter by expansion of early tumour cells, is a key driver of glioblastoma progression.

This week #JournalClub @labsoap.bsky.social @nature.com #glioblastoma #injury #neuroscience #initiation #progression www.nature.com/articles/s41...

Editors Choice Articles: Traffic Traffic is a cell biology and biochemistry journal devoted to intracellular transport, covering subcellular trafficking, membrane dynamics, organelle function & more.

Editor's selected articles of the last two years onlinelibrary.wiley.com/doi/toc/10.1...

DHRS13 suppresses differentiation and mitophagy in glioma via retinoic acid and mitochondrial reactive oxygen species - Nature Communications Cancer stem-like cells contribute to tumor growth and therapy resistance in glioblastoma. Here, authors identify that DHRS13 inhibition promotes differentiation of glioma stem-like cells by activating...

This week #JournalClub @labsoap.bsky.social #mitophagy #differentiation #stemness #cancer @nature.com www.nature.com/articles/s41...

#ResultatScientifique 🔎 | Glioblastome : la molécule JAMC agit comme un “frein” naturel, limitant la migration des cellules souches tumorales dans le cerveau. 🧠
✍️ Julie GAVARD
📕 @cp-cellreports.bsky.social | buff.ly/CKaIOu9

🙏 @cnrsbiologie.bsky.social pour la mise en avant de nos travaux #neurooncologie #glioblastome

🧠🔬Targeting #celladhesion #JAMC to limit #glioblastoma #stemcell #invasion
📄 @cellpress.bsky.social www.sciencedirect.com/science/arti...
🙏 co-authors and support @cnrsbiologie.bsky.social @insermgrandouest.bsky.social #Nantes #Angers Universities #LigueContreCancer @fondationarc.bsky.social #INCA

WSTF nuclear autophagy regulates chronic but not acute inflammation - Nature During chronic but not acute inflammation, chromatin remodelling is influenced by nuclear autophagy through WSTF interaction with ATG8 in the nucleus, leading to WSTF nuclear export and its subsequent...

This week #JournalClub @LabSoap #nuclear #autophagy #inflammation @nature.com www.nature.com/articles/s41...