LabSoap

WSTF nuclear autophagy regulates chronic but not acute inflammation - Nature During chronic but not acute inflammation, chromatin remodelling is influenced by nuclear autophagy through WSTF interaction with ATG8 in the nucleus, leading to WSTF nuclear export and its subsequent...

This week #JournalClub @LabSoap #nuclear #autophagy #inflammation @nature.com www.nature.com/articles/s41...

Centromeric DNA amplification triggered by viral proteins activates nuclear cGAS Herpesvirus proteins disrupt centromeres, triggering centromeric DNA amplification and local nuclear activation of the nucleic acid sensor cGAS. This reveals an immune surveillance mechanism in the nu...

This week #JournalClub @LabSoap @cellpress.bsky.social #CGAS #DNAamplification #virus www.cell.com/cell/abstrac...

Red blood cells undergo lytic programmed cell death involving NLRP3 Complement exposure induces programmed cell death of red blood cells due to the intracellular activation of miniNLRP3 and caspase-8. Inhibiting NLRP3 signaling reduces cytoskeletal damage and prevents...

This week #JournalClub @labsoap.bsky.social #celldeath #RedBloodCell #Inflammasome @cellpress.bsky.social www.cell.com/cell/abstrac...

Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs This study uncovers the molecular mechanism of LAG3 activation upon ligand engagement and its regulation by non-degradative polyubiquitination within the tumor microenvironment. The findings highlight...

This week #JournalClub @labsoap.bsky.social #LAG3 #immunecheckpoint @cellpress.bsky.social www.cell.com/cell/fulltex...

Glioblastoma shift from bulk to infiltrative growth is guided by plexin-B2-mediated microglia alignment in invasive niches - Nature Cancer Kang et al. define distinct spatial niches within glioblastoma (GBM) tumors according to their infiltrative nature and report that glioma cells induce microglia and macrophage alignments through plexi...

This week #JournalClub @labsoap.bsky.social @natcancer.nature.com #glioblastoma #Plexin #infiltration www.nature.com/articles/s43...

#BeatPlasticChallenge #ImproveourResearchPractice #LittlebyLittle

Important Fact: Higher Education and Research is the place where LGBTI+phobic assaults are most common.

What can we do?
- Continue to stay informed and educated
- Include and make LGBTI+ people visible
- Reject harmful behaviors

Here is our SOAPainbow 🌈

NEMO is essential for directing the kinases IKKα and ATM to the sites of DNA damage The protein NEMO coordinates the recognition of DNA damage to initiate repair.

This week #JournalClub @labsoap.bsky.social @science.org #Nemo #IKK #DDR www.science.org/doi/10.1126/...

Excellent science and friendly atmosphere at the #JSNU2025 #glialcommunication #symposium And great talks from @laisbfugio.bsky.social #quentinroux 🤩

Activation of lysosomal iron triggers ferroptosis in cancer - Nature Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.

This week #JournalClub #ferroptosis #iron #lysosome @nature.com @institutcurie.bsky.social www.nature.com/articles/s41...

VDAC2 loss elicits tumour destruction and inflammation for cancer therapy - Nature VDAC2 deficiency elicits uncontrolled IFNγ-induced BAK activation and mitochondrial damage for improved cancer therapy.

This week #JournalClub @labsoap.bsky.social #mitochondria #inflammation #tumor @nature.com www.nature.com/articles/s41...

Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium - Nature Dynamic cytoskeletal regulation of lymphatic endothelial cell shape, induced by isotropic stretch and crucial for dermal lymphatic capillary function, is identified and found to result from continuous...

This week #JournalClub @labsoap.bsky.social @nature.com @taijamakinenlab.bsky.social #lymphatics #cellshape
#cytoskeleton
www.nature.com/articles/s41...

Important Fact: Higher Education and Research is the place where LGBTI+phobic assaults are most common.

What can we do?
- Continue to stay informed and educated
- Include and make LGBTI+ people visible
- Reject harmful behaviors

Here is our SOAPainbow 🌈

Un article intéressant sur les #PFAS rédigé par un petit groupe de lycéennes #nantes dans le cadre de programme Jeunes Reporters pour l’Environnement, porté par Teragir. Bravo !

Happy Earth Day 🌎 🍃🌱💦

Effective targeting of PDGFRA-altered high-grade glioma with avapritinib PDGFRA is commonly altered in pediatric HGG. Mayr et al. report that the PDGFRA/KIT inhibitor avapritinib demonstrates on-target activity, brain penetrance, and survival benefit in pre-clinical H3K27M...

This week #JournalClub @labsoap.bsky.social #PDGFRA #HGG #BrainTumor @cp-cancercell.bsky.social @sinaneyazi.bsky.social
www.cell.com/cancer-cell/...

Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...

This #JournalClub @labsoap.bsky.social #Lysosomes #CellDeath #Degradation @science.org @robzonculab.bsky.social www.science.org/doi/10.1126/....

👏 Congratulations #YanisMace @nbidere.bsky.social @tiphainedouanne.bsky.social @insermgrandouest.bsky.social
🔍 CYLD cell death and more

Single-cell atlas of endothelial and mural cells across primary and metastatic brain tumors Central nervous system malignancies include primary tumors and brain metastases (BrMs) originating from extracranial cancers. Bejarano et al. examine primary and metastatic brain tumors and find disti...

This week #JournalClub in @labsoap.bsky.social on #endothelial #mural #atlas #braintumors in @cp-immunity.bsky.social from @johannajoyce.bsky.social
www.cell.com/immunity/ful...

Again our Team @labsoap.bsky.social #CRCI2NA @insermgrandouest.bsky.social organize an internal picture contest to apply for the best "ecosystem" picture in 2025 CRCI2NA
Here are all the beauties prior though selection and we actually won 🥇🥈🥉 and you which one would have chosen?

Check this #JS2025 #colloque #GLICO Glial communication 🧠
🎤 @wboesmans.bsky.social @candicechaps.bsky.social #IBrunet #QRoux @laisbfugio.bsky.social #VMoulle #CLeBerre
💻 #MDerkindren #TDurand @labsoap.bsky.social
🗓️ 27-05 Nantes
🚧 Free Registration limited seats
js.univ-nantes.fr/jassiste-aux...

Leucine aminopeptidase LyLAP enables lysosomal degradation of membrane proteins Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic dataset...

www.science.org/doi/10.1126/... #lysosomes 😍

@traffic-journal.bsky.social is a cell biology and biochemistry journal devoted to intracellular transport in health and disease. We cover a broad range of disciplines, such as developmental biology, neuroscience, immunology, and infection in eukaryotes. Choose @traffic-journal.bsky.social

Blebbisomes are large, organelle-rich extracellular vesicles with cell-like properties - Nature Cell Biology Jeppesen, Sanchez et al. identify blebbisomes as large membrane-enclosed vesicles containing organelles and secreted by cells. Blebbisomes can both secrete and internalize exosomes and microvesicles.

This week @labsoap.bsky.social #JournalClub #bleb #extracellularvesicle @naturecellbiology.bsky.social www.nature.com/articles/s41...

Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling Diet influences macronutrient availability to cells, and although mechanisms of sensing dietary glucose and amino acids are well characterized, less is known about sensing lipids. We defined a nutrien...

www.science.org/doi/10.1126/...

Adaptor‐Mediated Trafficking of Tank Binding Kinase 1 During Diverse Cellular Processes TBK1 and its adaptor signaling play a crucial role in diverse biological processes, including innate immunity, selective autophagy, and mitosis.

just published onlinelibrary.wiley.com/doi/full/10....

a beautiful paper for #JournalClub @labsoap.bsky.social

FEBS Press ‘Who in their right mind would add another meeting to an already overflowing schedule?’ This thought crossed our minds when we first discussed the idea of a postdoc peer group meeting. We are five ea...

Happy to share this piece by @labsoap.bsky.social's postdocs @laisbfugio.bsky.social, #JaneJardine, @sararosinska.bsky.social, #QuentinRoux, and myself on postdoc peer meetings and co-development. @febspress.bsky.social. @insermgrandouest.bsky.social.
febs.onlinelibrary.wiley.com/doi/full/10....

This is fantastic!!!!! So much insight here, congratulations to all the authors!!

Huge congratulations to the postdocs from @labsoap.bsky.social for this inspiring essay. Very happy to see it published.
A must Read!