Traffic

Traffic Traffic is a cell biology and biochemistry journal devoted to intracellular transport, covering subcellular trafficking, membrane dynamics, organelle function & more.

onlinelibrary.wiley.com/journal/1600... Traffic is a cell biology and biochemistry journal devoted to intracellular transport in health and disease, covering disciplines such as developmental biology, neuroscience, immunology, and infection in eukaryotes.

Eukaryote‐Wide Distribution of a Family of Longin Domain‐Containing GAP Complexes for Small GTPases The three longin domain-containing GAP complexes - CSW, folliculin, and GATOR1 - have a sporadic but pan-eukaryotic distribution and were likely already present in LECA in some form. Their catalytic ...

Just published! onlinelibrary.wiley.com/doi/10.1111/...

✍️ The Jackson/Verbavatz Lab contributed to the publication of a new article
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📃 Eukaryote-Wide Distribution of a Family of Longin Domain-Containing GAP Complexes for Small GTPases
🔗 onlinelibrary.wiley.com/doi/10.1111/...

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Traffic has two calls for papers running: on #clathrin to to celebrate the 50th anniversary of its discovery and #UPS #unconventionalproteinsecretion onlinelibrary.wiley.com/page/journal...

Traffic has two calls for papers running: on #clathrin to to celebrate the 50th anniversary of its discovery and #UPS #unconventionalproteinsecretion onlinelibrary.wiley.com/page/journal...

Salmonella Typhimurium Manipulates Syntaxin 7 to Navigate Endo‐Lysosomal Trafficking in Host Cells Salmonella Typhimurium hijacks the host Qa-SNARE syntaxin 7 (STX7) to manipulate endo-lysosomal trafficking and sustain intracellular survival. STX7 displays cell–type–specific expression and localis...

Just published onlinelibrary.wiley.com/doi/10.1111/...

TENT5/FAM46: An Enigmatic Family of Secretory Tuners TENT5s multifaceted roles in key biological processes and human diseases. TENT5 is a family of four proteins (TENT5A–D) with tissue-specific functions influencing tumor proliferation, fertility, bone....

Just published onlinelibrary.wiley.com/doi/10.1111/...

A Sensitive and Versatile Cell‐Based Assay Combines Luminescence and Trapping Approaches to Monitor Unconventional Protein Secretion In this study, Denus et al. develop a powerful and highly customizable split luciferase-based assay allowing the analysis of multiple cargo proteins released by unconventional protein secretion. This...

Just published onlinelibrary.wiley.com/doi/10.1111/...

BicD and MAP7 Collaborate to Activate Homodimeric Drosophila Kinesin‐1 by Complementary Mechanisms Kinesin-1 is auto-inhibited and binds microtubules weakly. Binding of kinesin-1 to the adaptor protein BicD enhances processive motion, while the microtubule-associated protein MAP7 recruits more kin....

Just published onlinelibrary.wiley.com/doi/10.1111/...

TNF‐α‐Driven Changes in Polarized EGF Receptor Trafficking Facilitate Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling From the Apical Surface of MDCK Epithelial Cells Epithelial-immune cell crosstalk is tightly regulated by secretion of immune cell mediators into luminal and serosal fluid spaces of epithelial tissues. We report two major new findings regarding how...

Just published onlinelibrary.wiley.com/doi/10.1111/...

Golgi Localized Arl15 Regulates Cargo Transport and Cell Adhesion The model illustrates the function of Arl15 in vesicular transport and cell surface organization. Arl15 localizes majorly to the Golgi and plasma membrane (PM), which is primarily dependent on Arf1-d...

Just Published: Golgi Localized Arl15 Regulates Cargo Transport and Cell Adhesion
Prerna Sharma, Pooja Hoovina Venkatesh, Shalini Samal, Neha Paddillaya, Nikita Shah, B. R. Rajeshwari, Abhay Bhat, Deepak Kumar Nayak, Archishman Dakua, Aravind Penmatsa …
doi.org/10.1111/tra....

Re‐Visiting the Intracellular Pathway of Transferrin on Board of a Mathematical Simulation The transport of transferrin is among the most extensively studied trafficking processes. In this commentary, we utilize a mathematical simulation of the endomembrane system to revisit transferrin tr...

Just Published: Re-Visiting the Intracellular Pathway of Transferrin on Board of a Mathematical Simulation
Franco Nieto, Luis S. Mayorga
doi.org/10.1111/tra....

Just Published: Golgi Localized Arl15 Regulates Cargo Transport and Cell Adhesion
Prerna Sharma, Pooja Hoovina Venkatesh, Shalini Samal, Neha Paddillaya, Nikita Shah, B. R. Rajeshwari, Abhay Bhat, Deepak Kumar Nayak, Archishman Dakua, Aravind Penmatsa … See all authors
doi.org/10.1111/tra....

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Acute GARP Depletion Disrupts Vesicle Transport, Leading to Severe Defects in Sorting, Secretion and O‐Glycosylation Cartoon illustrating defects caused by GARP dysfunction. (Left) Control cells exhibit normal Golgi morphology with a stratified distribution of enzymes and trafficking machinery. (Right) Following ac...

just published onlinelibrary.wiley.com/doi/full/10....

Computational Modeling Reveals a Catch‐and‐Guide Interaction Between Kinesin‐1 and Tubulin C‐Terminal Tails Previous experiments show a decrease in kinesin-1's processivity and velocity when tubulin C-terminal tails (CTTs) are cleaved, but the mechanism of these effects remains unclear. We devise competing...

just published onlinelibrary.wiley.com/doi/full/10....

Adaptor‐Mediated Trafficking of Tank Binding Kinase 1 During Diverse Cellular Processes TBK1 and its adaptor signaling play a crucial role in diverse biological processes, including innate immunity, selective autophagy, and mitosis.

just published onlinelibrary.wiley.com/doi/full/10....

Disease‐Associated Factors at the Endoplasmic Reticulum–Golgi Interface The ER–Golgi interface has garnered significant attention due to recent discoveries suggesting potential non-vesicular transport mechanisms and regulation through liquid-liquid phase separation. Nume...

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PcloC‐Mediated Phase Separation in Short‐Distance Vesicle Transport Phase separation is increasingly recognized as a paradigm to elucidate the self-assembly and organization of membrane-less bodies within the cell, which involves the segregation of a multi-component ...

onlinelibrary.wiley.com/doi/abs/10.1...

Traffic Traffic is a cell biology and biochemistry journal devoted to intracellular transport, covering subcellular trafficking, membrane dynamics, organelle function & more.

onlinelibrary.wiley.com/journal/1600... Traffic is a cell biology and biochemistry journal devoted to intracellular transport in health and disease, covering disciplines such as developmental biology, neuroscience, immunology, and infection in eukaryotes.

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