Serini Lab

Pulsatile flow dynamics determine pulmonary arterial architecture BACKGROUND Single ventricle congenital heart disease (SV-CHD) is a uniformly lethal condition. Survival depends upon the Glenn surgery, which shunts venous blood directly to the pulmonary arteries wit...

Happy to share our work on the role of biomechanical PULSATILITY on lung vessels.

Following surgery to alleviate overload in kids with single ventricle hearts, lung arteries form AVMs. #DevBio #EndothelialCell #CHD

Beautiful work from Steve Spurgin. #DevBio 🫁 🫀 ❤️‍🩹

www.biorxiv.org/content/10.1...

EndoMAP.v1 charts the structural landscape of human early endosome complexes - Nature A study presents EndoMAP.v1, a resource that combines information on protein interactions and crosslink-supported structural predictions to map the interaction landscape of early endosomes.

Nature research paper: EndoMAP.v1 charts the structural landscape of human early endosome complexes

https://go.nature.com/3Z6mJ1X

The cellular dance that splits vessels

Really appreciate this insightful commentary by Dr. Lance Munn on our recent paper @pnas.org using Microvessel-On-A-Chip to model the pillariogenesis during early #IntussusceptiveAngiogenesis 😎

pnas.org/doi/abs/10.1073/pnas.2508260122

EpiSci - Hi there! Our review “Mechanotransduction in stem cells” is finally published. With @carstenschulte4.bsky.social we provided a comprehensive picture, that aims to cover the whole mechanotransductive pathway from the cell microenvironment to the nucleus. 1/3 pubmed.ncbi.nlm.nih.gov/38729084/

1/I'm excited to share my review with CSHL exploring the concept of neighbouring cells as substrate to guide the collective migration of other cells. We tend to focus on cell-matrix interactions, but forget that within tissue, cell-cell interactions exist.
cshperspectives.cshlp.org/content/earl...

Congrats, Johanna!

Honored to have been elected with Patrick Caswell @mcrcellmatrix.bsky.social co-chair of the 2029 Gordon Research Conference on Fibronectin, Integrins, and Related Molecules!
We have big shoes to fill: www.grc.org/fibronectin-..., but are up for the challenge!

Xiao, G. et al. (2025). Intratumor HIF-1a modulates production of a cachectic ligand to cause host wasting. Cell Insight. doi: 10.1016/j.cellin.2025.100247. PMID: 40336592

Improved Tumor Blood Flow Enhances the Abscopal Effect: Preclinical Assessment in Mice Treated with Combined Radiation and PD-1 Blockade Therapy https://www.biorxiv.org/content/10.1101/2025.05.04.652150v1

Targeting the SHOC2–RAS interaction in RAS-mutant cancers - Nature A study of dependencies associated with cancer-causing mutations has identified a small molecule that binds to SHOC2 and inhibits RAS signalling in cells carrying NRAS Q61 mutations, a common onc...

new out in Nature www.nature.com/articles/s41...

Activation of lysosomal iron triggers ferroptosis in cancer - Nature Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.

📣 Publication in @nature.com
A new class of molecules capable of killing #cancer cells that are refractory to standard treatments and responsible for recurrence has just been developed by scientists at Institut Curie, @cnrs.fr and @inserm.fr

Read publication 👉 www.nature.com/articles/s41...

Spatial and stoichiometric in situ analysis of biomolecular oligomerization at single-protein resolution - Nature Communications Extracting quantitative information on biomolecular oligomerisation with high resolution remains a significant challenge. Here, the authors propose SPINNA, a framework that compares nearest-neighbour ...

Spatial and stoichiometric in situ analysis of biomolecular oligomerization at single-protein resolution

We are excited to present our latest work published in @natcomms.nature.com

www.nature.com/articles/s41...

Viscoelastic extracellular matrix enhances epigenetic remodeling and cellular plasticity - Nature Communications Extracellular matrices are viscoelastic, yet how matrix viscoelasticity regulates the epigenome remains unclear. Here, the authors show that cells cultured on viscoelastic matrices exhibit changes in ...

www.nature.com/articles/s41...

Representing the TME working group, @megeblad.bsky.social just presented a mesmerizing talk about the role of #neutrophils and their DNA traps inside vessels at the necrotic and peri necrotic niches and their role in metastasis
A true eye opener!!! #AACR25 @theaacr.bsky.social

Ludwig @harvard.edu’s Rakesh Jain, recipient of the #AACR2025 Award for Lifetime Achievement in Cancer Research, told the tale of his 4-decade journey from proposing the vascular normalization hypothesis to seeing it applied today to treat multiple cancers. bit.ly/3Egq1bv

KRIT1 heterozygous mutations are sufficient to induce a pathological phenotype in patient-derived iPSC models of cerebral cavernous malformation Arce et al. show that KRIT1 heterozygous mutations drive cavernoma-like structures in vascularized organoids and alter endothelial cell-cell junctions. KRIT1-deficient vascular cells reshaped brain vasculature through extracellular matrix organization, proliferation, and mesenchymal transition. The endothelial progenitor marker PEG3 was highly expressed in CCM patient-derived endothelial cells and patient cavernoma biopsies.

KRIT1 heterozygous mutations are sufficient to induce a pathological phenotype in patient-derived iPSC models of cerebral cavernous malformation

Interplay of actin nematodynamics and anisotropic tension controls endothelial mechanics Nature Physics - Blood flow through a vessel deforms vessel walls. Cells lining these walls sense the changes in pressure as blood flows and reorient their actin fibres in the direction of largest...

Very happy and excited to share our latest work linking actin nematodynamics and endothelial cell mechanics under anisotropic tension, now published in @natphys.nature.com ! rdcu.be/eigWi

@ipparis.bsky.social @polytechniqueparis.bsky.social

JCS poster on regulation of cell migration by extracellular matrix mechanics at a glance Cole Allan, Ovijit Chaudhuri

Also in Issue 7:
- Research Highlights on ATG9A INVs, airway epithelia & Formin 3
- JCS–David Stephens Prize
- Emmanuel Derivery @deriverylab.bsky.social Interview
- Regulation of cell migration by ECM mechanics
- Data exploration in quantitative #cellbio
journals.biologists.com/jcs/issue/13...

Just published!🎉
Excited to present Pickering lab's work on @pnas.org
#IntussusceptiveAngiogenesis-On-A-Chip🤩

For 1st time in vitro, we rebuilt multicellular pillars composed of #EndothelialCells crossing a pressurized, flowing channel🤓

Kudos to our stellar Sabrina🌟
www.pnas.org/doi/10.1073/...

Functions & application of circRNAs in #VascularAging & aging-related vascular diseases

miR sponge
Linear mRNA translation
Interact with epigenetic/transcriptional machinery
Form R-loop on host gene
Protein-coding

#JNanobiotech 2025
jnanobiotechnology.biomedcentral.com/articles/10....

The fibroinflammatory response in cancer

#REVIEW 🚨
Fibroinflammation contributes to tumour initiation, growth and metastasis. Zebin Xiao & Ellen Puré outline the complexity of cancer-associated fibroinflammation and provide insights on therapeutically targeting this.
@upenn.edu
👀 ⬇️

A #collagen IV fluorophore knock-in toolkit reveals trimer diversity in #Celegans basement membranes. A new toolkit from Sandhya Srinivasan, David Sherwood and colleagues @duke-university.bsky.social: rupress.org/jcb/article/...

#Development #Adhesion #Disease #Migration #motility

In Memoriam: Wolfenson, Giannone, and Schwartz recall the life and many contributions of Michael Sheetz, who passed away on January 30, 2025. rupress.org/jcb/article/...

Lung fibrosis

Fibrosis: cross-organ biology and pathways to development of innovative drugs www.nature.com/articles/s41...
rdcu.be/eejqi

This new Review highlights core pathways active in fibrotic conditions across organs, and proposes strategies to improve the translation of potential antifibrotic drugs

A figure depicting the concept of cancer attractor states within Waddington's landscape, and how gene regulatory network dynamics influence these states.

Genome sequencing & single-cell transcriptomics continue to produce findings that challenge the idea that #cancer is purely a genetic disease. This Essay delves into #omics data that questions the somatic mutation theory & presents alternative theories based on GRNs & tissue fields.🧪
plos.io/3DRtAEW

Researchers led by Ludwig @fbm-unil.bsky.social’s
@lbejarano.bsky.social & @johannajoyce.bsky.social analyzed individual cells of the blood-brain barrier across brain tissue, primary brain tumors & brain metastases, creating a vascular atlas to guide the design of new therapies.

bit.ly/4bFqwYY

Cancer attractors on the epigenetic landscape. Mathematically, the epigenetic landscape can be extended to regions that represent gene activation configurations (in pink) that exist in theory but are never realized during development and in physiological tissues (green traces descending the hill in the gray regions). The unused regions (pink) contain unoccupied attractors—the cancer attractors. Under abnormal conditions cells can, upon massive perturbation of their gene expression profile, enter such cancer attractors that lack a path to the normal mature cell type attractors (bottom)—and thus are “maturation-arrested” and, if associated gene activation configurations are compatible with cell viability, can become cancerous. Mutations rewire the gene regulatory network (GRN), thus altering the dynamics, which can result in lowering of the barriers (hills) that prevent cells from leaving the physiological regions, facilitating the occupation of cancer attractors.

"The end of the genetic paradigm of cancer" - a provocative piece in @plosbiology.org from Sui Huang, Ana Soto & Carlos Sonnenschein: "We expect that the diminishing returns from the ceaselessly growing databases of somatic mutations... may soon reach a pivot point" journals.plos.org/plosbiology/...

Interesting. Includes two leukocyte integrin subunits.

Proteins that allow water to move in and out of cells help shape the development of new blood vessels.
buff.ly/Sl19tgH

Congratulations to Ludwig @unil.bsky.social’s Douglas Hanahan on being honored with the 2025 Pezcoller Foundation-@theaacr.bsky.social International Award for Extraordinary Achievement in Cancer Research for his seminal contributions to the field. Learn more here: bit.ly/3DGCnt6

#CanSky #OncoSky