Multi-omic analysis reveals transkingdom gut dysbiosis in metabolic dysfunction-associated steatotic liver disease Nature Metabolism, Published online: 02 July 2025; doi:10.1038/s42255-025-01318-6High-resolution multi-omic profiling indicates widespread gut dysbiosis in individuals with MASLD, also affecting the virome, and reveals microbial signatures that can classify MASLD and its subtypes.

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Viewing MASLD through an integrative gut microbiome lens Nature Metabolism, Published online: 02 July 2025; doi:10.1038/s42255-025-01300-2The gut microbiome is pivotal to the development of liver diseases in multifaceted ways. A recent study uses a multi-omics, multi-kingdom approach to analyse the gut dysbiosis in metabolic dysfunction-associated steatotic liver disease, highlighting a substantial role for oral-typical microorganisms and their associated metabolites.

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I am deeply grateful to @longnguyen.bsky.social @chuttenh.bsky.social for their guidance throughout the project. Also, I would like to acknowledge and thank all our amazing collaborators from @harvardmed.bsky.social @hsph.harvard.edu @broadinstitute.org who made this work possible! (6/6)

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💡Altered metabolic profiles in MASLD, including reduced bile acids (e.g., isoallolithocholic acid) and increased long-chain acylcarnitines.

🧬All data are available at biom-mass.org, as well as the NIH-sponsored repositories. (5/6)

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💡Distinct microbial signatures between non-lean MASLD (body mass index [BMI] ≥25 kg/m2) vs. lean MASLD (BMI <25 kg/m2)—the latter being a paradoxical subtype of a disease typically associated with increased adiposity. (4/6)

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🔬Using multi-omic profiling (stool DNA, RNA, and metabolites), we discovered:
💡Transkingdom dysbiosis involving gut bacteria and viruses in MASLD
💡Widespread colonization of oral microbes, such as Veillonella and Streptococcus spp., in the gut of individuals with MASLD (3/6)

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Our findings provide new insights into the gut-liver axis and the role of the microbiome in the etiopathogenesis of MASLD—a condition characterized by fat accumulation in the liver. (2/6)

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Revealing the Relationship Between the Gut Microbiome and Metabolic Dysfunction-Associated Steatotic Liver Disease | Mass General Brigham Hanseul Kim and Long H. Nguyen, MD, MS discuss their new paper, “Multi-omic analysis reveals transkingdom gut dysbiosis in metabolic dysfunction-associated steatotic liver disease.”

🔗Press release:
www.massgeneralbrigham.org/en/about/new...
🔗Also, check out this amazing summary in News & Views by @tao-zuo.bsky.social:
www.nature.com/articles/s42... (1/6)

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⚡🦠I'm very excited to share our latest work on the gut microbiome and metabolic dysfunction-associated steatotic liver disease (MASLD) is published in @natmetabolism.nature.com, with @hutlab.bsky.social & @longnguyen.bsky.social!

🔗Check out the paper here:
www.nature.com/articles/s42...

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