Tao Zuo

Pushing the frontier of gut microbiome health cross-kingdom and cross-organ Nature Reviews Gastroenterology & Hepatology, Published online: 03 November 2025; doi:10.1038/s41575-025-01140-1The gut microbiome presents in a multi-kingdom form and tunes host health in various ways. Studies published in 2025 have further pushed this frontier by unveiling the enigmatic roles of the gut fungi and bacteria in cross-organ regulations of host homeostasis through metabolite and immune cell-mediated pathways.

ICYMI: New online! Pushing the frontier of gut microbiome health cross-kingdom and cross-organ

Our invited Year in Review piece on the topic of gut microbiome is out at Nature Reviews Gastroenterology & Hepatology @natrevgastrohep.nature.com 🌟
www.nature.com/articles/s41...

Engineered Metarhizium fungi produce longifolene to attract and kill mosquitoes - Nature Microbiology Insects colonized with Metarhizium fungi emit longifolene to lure new hosts for infection to disperse spores. A fungal strain was engineered to emit longifolene to attract and eliminate mosquitoes.

OUT NOW! - Engineered Metarhizium fungi produce longifolene to attract and kill mosquitoes 🍄🧲🦟☠️

By Dan Tang, Jun Cao, Raymond Leger, Jianhua Huang, Weiguo Fang & colleagues.

www.nature.com/articles/s41...

Dietary urbanization destabilizes host-gut microbiome homeostasis and informs precision nutrition for human health Since the industrial revolution, human dietary habits have invariably trended toward dietary urbanization, during which the human gut microbiota has r…

www.sciencedirect.com/science/arti...

Our diet-microbiome interaction and informed precision nutrition article is finally out at Cell Metabolism. @Cell Thank you to all of our collaborators!

However, using them to treat a non-infectious disease or studying the mechanisms behind bacteriophages regulating Commensal bacteria are promising and interesting area of research in future

Using bacteriophages to diagnose a disease is infeasible presently as bacteriophages are highly individualized and ever-evolving.

New research article

Evaluation of bacteriophages as a signature of #microbiome health: a systematic review and meta-analysis

www.thelancet.com/journals/lan...

#IDSky #ClinMicro #ViroSky #Phage #OpenAccess #OA

SOOOOO excited to see this online IN REAL-LIFE!!

Here, we review the latest in hepatic tissue-resident #Tcell biology. We draw on a metaphor proposed by Robert Louis Stevenson [1886] to highlight the fact a cell can manifest different behaviours & actions depending on environmental context 🧪

A timetree of Fungi dated with fossils and horizontal gene transfers - Nature Ecology & Evolution Combining fossil-based and molecular calibrations with data on horizontal gene transfer events, the authors develop a time-calibrated phylogeny of Fungi. This timescale, which integrates analytic uncertainties, suggests an older age of crown Fungi (1,401–896 million years ago), as well as a minimum age for ancient interactions involving fungi and the algal ancestors of embryophytes in terrestrial ecosystems (1,253–797 Ma).

A paper in Nature Ecology & Evolution presents a time-calibrated phylogeny of Fungi. This timescale suggests an older age of crown Fungi, as well as a minimum age for ancient interactions involving fungi and the algal ancestors of embryophytes in terrestrial ecosystems. #phylo 🧪

Commensal yeast promotes Salmonella Typhimurium virulence - Nature Commensal Candida albicans enhances the virulence and dissemination of Salmonella enterica subsp. enterica serovar Typhimurium.

Nature research paper: Commensal yeast promotes Salmonella Typhimurium virulence

go.nature.com/4mTnRzG

Glucagon-like Peptide-1 receptor agonists as emerging therapeutics in bipolar disorder: a narrative review of preclinical and clinical evidence - Molecular Psychiatry Molecular Psychiatry - Glucagon-like Peptide-1 receptor agonists as emerging therapeutics in bipolar disorder: a narrative review of preclinical and clinical evidence

We know GLP-1 drugs reduce brain inflammation. But I didn't anticipate bipolar disorder as a possible indication in the future
www.nature.com/articles/s41...

A mammoth toothache: bacterial community discovered in mouth of ancient mammal Genetic-sequencing techniques have uncovered the oldest host-associated microbial DNA ever recorded — inside samples of teeth and bones from woolly and steppe mammoths.

Genetic-sequencing techniques have uncovered the oldest host-associated microbial DNA ever recorded — inside samples of teeth and bones from woolly and steppe mammoths.

go.nature.com/4mNN3aS

This is a piece I am super interested in

I believe some of the bacteria within the food microbiome are functional in terms of for both fermentation and health effect on humans, yet most of the other co-occurring bacteria within it might be minor and dead ones due to perhaps contaminations

This is figure 1, which shows understanding the four epidemiologic stages of IBD evolution.

A Perspective in Nature Reviews Gastroenterology & Hepatology explores the global evolution of inflammatory bowel disease over the next 20 years and proposes strategies for prevention and health-care innovation. go.nature.com/4fW7sYy #medsky 🧪

Interstingly, a single bacterium can use both canonical polar peptidoglycan synthesis and MreB-dependent dispersed peptidoglycan synthesis pathwasys for their exloratory growth...

Nice to see some familiar names from @mimsumea.bsky.social 😊 Congratulations!

US has slashed global vaccine funding – if philanthropy fills the gap, there could be some trade-offs Now that the US has stopped funding Gavi, the vaccine alliance will likely become more dependent on philanthropy than ever before.

"[Gavi] would be even more helpful if they could more consistently help countries build the strong and lasting vaccination systems that low-income and medium-income countries need to make sure vaccines can eventually be delivered without foreign aid."

theconversation.com/us-has-slash...

Interesting study 👍

😧 scary!

Maybe more reasons to stick to cooking with unprocessed raw ingredients?

Our study on the dietary whey protein and its effect on gut phageome and bacteriome, protecting against Crohn’s disease, made to the cover of the journal Gut.

Our News & Views piece is out at Nature Metabolism. We discussed the role of gut virome in MASLD, particularly the importance of virome
www.nature.com/articles/s42...

New online! Post-antibiotics microbiome restoration driven by diet

It indeed has been drizzling on and off in the past few days…

A study of 981 colorectal cancers in 11 countries shows geographic & age-related variations in mutational processes & suggests that early-life mutagenic exposure to colibactin-producing bacteria may contribute to the rising incidence of early-onset colorectal cancer 🧪

www.nature.com/articles/s41...

I agree, AI should not be used as peer reviewer!

😱

Dietary whey protein protects against Crohn’s disease by orchestrating cross-kingdom interaction between the gut phageome and bacteriome Background The gut microbiome and diet are important factors in the pathogenesis and management of Crohn’s disease (CD). However, the role of the gut phageome under dietary influences is unknown. Obj...

Our study on how diet may regulate the gut phageome-bacteriome interaction relaying to a disease protection, #IBD, is freshly out at the journal #Gut

gut.bmj.com/content/earl...