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M. Brent Hawkins

@homeobox.bsky.social

Developmental genetics and evolution of the vertebrate skeleton. Postdoc in the Harris Lab at Boston Children's Hospital/Harvard Medical School. Every day is fin day. He/him/his.

364 Followers  |  312 Following  |  79 Posts  |  Joined: 16.07.2023
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Posts by M. Brent Hawkins (@homeobox.bsky.social)

The proventriculus lacks stem cells, but compensates for
age-related cell loss via
endoreplication
Ben Ewen-Campen
Perrimon Lab, Harvard Medical School
Fly Meeting 2026

The proventriculus lacks stem cells, but compensates for age-related cell loss via endoreplication Ben Ewen-Campen Perrimon Lab, Harvard Medical School Fly Meeting 2026

I'M RUNNING
FOR
STATE REP!

I'M RUNNING FOR STATE REP!

πŸͺ°If you’re at #Dros26 and are interested in the fly foregut AND/OR want to support scientists in elected office, please come to talk Friday at 9:45am AND/OR support my run for State Representative in MA :)

www.benforward3.com/blog/2026/3/...

05.03.2026 01:17 β€” πŸ‘ 13    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

Join us this next Friday *the 13th* πŸ‘» πŸ‘» to hear us talking about bones and cartilages in development and evolution 🐟 🐠 🦴

04.03.2026 03:27 β€” πŸ‘ 14    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0
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πŸŸπŸ‘€ SFSU Biology seminar β€” Thu Mar 5
2–3pm | SEC 116
Dr. Patricia Schneider (LSU): β€œSplit Screens: Exploring Vision through the Eyes of the Four-Eyed Fish.”
Student time: 3–3:30pm. Come by!

03.03.2026 03:51 β€” πŸ‘ 8    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0

Super excited about these results and new system.

Mapping, Expression, Loss-of-Function

I'm floored by how this locus seem to integrate all the spatial info to sketch the minute details of the phenotype, and how this is prone to evol tweaks

Large hyperdiverged haplotype without an inversion.

25.02.2026 22:50 β€” πŸ‘ 24    πŸ” 5    πŸ’¬ 1    πŸ“Œ 0
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Neil H. Shubin has been elected as the next NAS President! A leading evolutionary biologist and science communicator, Shubin will succeed Marcia McNutt on July 1. The Academy also named Cherry Murray as International Secretary and elected new councilors. Read more: www.nasonline.org/news/2026_pr...

04.02.2026 17:35 β€” πŸ‘ 153    πŸ” 31    πŸ’¬ 5    πŸ“Œ 8

πŸ§ͺπŸ”¬πŸ§¬Beautiful work! Many people have long wondered what the impact of actinodin loss would be on fin development.

www.biorxiv.org/content/10.6...

23.01.2026 18:18 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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It’s out! 🐟 We compared three regeneration superstarsβ€”axolotl, zebrafish, and Polypterusβ€”to ask how animals regrow limbs and fins. We find shared core processes, and other programs fine-tuned by evolution in surprising, lineage-specific ways. tinyurl.com/mpftkn7y

22.01.2026 17:38 β€” πŸ‘ 68    πŸ” 24    πŸ’¬ 1    πŸ“Œ 2
Everything I Thought I Knew About Flavor Was Wrong
YouTube video by Be Smart Everything I Thought I Knew About Flavor Was Wrong

@pbs.org has had my whole heart since I was little little, so it is very surreal to be writing for a PBS Digital Studios show! Here is my first episode of Be Smart:

www.youtube.com/watch?v=4SBX...

Thank you @drjoehanson.bsky.social & team! My nose knowledge now knows no bounds πŸ‘ƒ

21.01.2026 17:07 β€” πŸ‘ 19    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0

Very happy to share that this paper is now online on @currentbiology.bsky.social !! πŸ₯³πŸ§ͺ Check out the final published verion here: www.cell.com/current-biol...
#mimuluspropaganda

24.11.2025 16:25 β€” πŸ‘ 113    πŸ” 34    πŸ’¬ 6    πŸ“Œ 1
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🚨New paper! 🚨
@jasminealqassar.bsky.social led this work on the silk glands of the pantry moth.

These two long tubes inside the caterpillar continuously make a ton of silk
How does this special organ work?

www.cell.com/iscience/ful...
@cp-iscience.bsky.social

🧡THREAD🧡

16.11.2025 02:06 β€” πŸ‘ 54    πŸ” 27    πŸ’¬ 1    πŸ“Œ 3

Toto, I have a feeling we aren't in Actinopterygii anymore

15.11.2025 23:12 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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It's out, Minos transgenesis in the pantry moth by
@donyaniyaz.bsky.social
@lucalivraghi.bsky.social

High efficient, glowing eye and silk gland markers

peerj.com/articles/202...
@peerj.bsky.social

12.11.2025 14:40 β€” πŸ‘ 46    πŸ” 16    πŸ’¬ 4    πŸ“Œ 4
Preview
Neil Shubin (1) | Collège de France

The talks (in english) can be accessed from the @college-de-france.fr website. A great journey through β€˜Our ancestors the fish’, from 380 Mio years ago to their hidden presence inside ourselves. Lessons #1 and #2 πŸ‘‡πŸΌ
www.college-de-france.fr/en/agenda/gu...
www.college-de-france.fr/en/agenda/gu...

07.11.2025 15:49 β€” πŸ‘ 2    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0

Pretty stoked that our article got the cover of the latest issue of @journalofanatomy.bsky.social!

Check it out here: doi.org/10.1111/joa....

05.11.2025 19:08 β€” πŸ‘ 9    πŸ” 3    πŸ’¬ 0    πŸ“Œ 1

Extremely cool to see very different systems potentially point to similar genetic constraints or developmental biases leading to morphological variation. Now we need a fish example!

04.11.2025 18:39 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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How do four-eyed fish see above & underwater? 🌀️🌊 Our new preprint reveals how Anableps rewired its retina for dual vision- evolution at work πŸ‘οΈπŸ‘οΈ Kudos to @perezlouise.bsky.social @josanesousa.bsky.social @keylapruett.bsky.social + team!
πŸ”— tinyurl.com/3a8r9xy5

04.11.2025 15:56 β€” πŸ‘ 39    πŸ” 19    πŸ’¬ 1    πŸ“Œ 0

Happy to have contributed to this big story. We present new genome assemblies, genus-wide complementation and allele-specific expression analyses in hybrids between zebrafish and closely related Danio species with divergent pigment patterns. A vertebrate model genus for basic comparative biology.

20.10.2025 02:20 β€” πŸ‘ 27    πŸ” 9    πŸ’¬ 1    πŸ“Œ 0
UMAP of single nucleus RNAseq dataset of Polypterus fin regeneration

UMAP of single nucleus RNAseq dataset of Polypterus fin regeneration

Hey Regen folks πŸ‘‹ Excited to share that our single-nucleus RNA-seq dataset for Polypterus fin regeneration is now live at the Broad Institute portal! Dive in here: tinyurl.com/5bck22jx
Big thanks to the team for making this happenβ€”looking forward to seeing what you all discover!

14.10.2025 17:08 β€” πŸ‘ 22    πŸ” 10    πŸ’¬ 0    πŸ“Œ 0

The regulation and evolution of proportion is a classic challenge in biology. This is exciting work into the genetic and developmental basis of proportionality using a very cool model. Congrats Ceri! πŸ‘πŸ§ͺ🧬🐭

14.10.2025 15:10 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Vertebral skeletal diversity in mammals is remarkable. How do the differences between vertebral size and shape develop and evolve? See how we tackled this question in our paper published in @natcomms.nature.com today!

10.10.2025 18:46 β€” πŸ‘ 49    πŸ” 15    πŸ’¬ 2    πŸ“Œ 1
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Tomorrow wednesday October 15th at 11am, first seminar of @neilshubin.bsky.social , guest Professor @college-de-france.fr on β€˜The history we share with fish’. Come, have a seat and enjoy learning where we come from. Free knowledge, no registration🀘

14.10.2025 07:43 β€” πŸ‘ 23    πŸ” 7    πŸ’¬ 0    πŸ“Œ 0

🚨 🚨 Science alert on a #FluorescenceFriday; check my latest paper published in @genetics-gsa.bsky.social where I integrated comparative tissue-specific transcriptomics and speciation genomics to discover two novel craniofacial genes behind pupfish extreme jaw development! tinyurl.com/craniofacial...

10.10.2025 20:06 β€” πŸ‘ 14    πŸ” 5    πŸ’¬ 0    πŸ“Œ 0

This is Hilma af Klint coded Esoteric Knowledge

10.10.2025 01:38 β€” πŸ‘ 6    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Found my halloween costume this is terrifying

09.10.2025 21:57 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

Hello #fish 🐟 🐠 researchers and PIs of tomorrow! We would be excited to sponsor you for an Ecology, Evolution and Behavior (EEB) Presidential #Postdoc Fellowship application @michiganstateu.bsky.social. Application deadline is Nov 10, so get in touch soom!

#EndlessFishMostBeautiful

27.09.2025 18:51 β€” πŸ‘ 27    πŸ” 21    πŸ’¬ 0    πŸ“Œ 0
Preview
Dual Bmp-negative feedback loops modulate function of both AER and ZPA to buffer and constrain postaxial digit number | PNAS Several lines of evidence indicate that posterior (postaxial) digit number in tetrapod vertebrates is constrained to the pentadactyl state by inter...

transport yourself to the late 90s with this really cool paper on digit number regulation by Shh and BMP, ZPA and AER. www.pnas.org/doi/10.1073/...

26.09.2025 18:54 β€” πŸ‘ 39    πŸ” 13    πŸ’¬ 3    πŸ“Œ 0

It is beautiful πŸ₯²

25.09.2025 22:43 β€” πŸ‘ 7    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

We will be taking phD students this round!! Apply to our @mpi-cbg.de phD programme and #growwithus

25.09.2025 18:56 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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My favourite figure from our new paper on lateral line development in Sterlet sturgeon (doi.org/10.7554/eLif...). In this one, we use targeted gene knockout and show that in (mosaic) absence of FoxG1, ectopic electroreceptors develop instead of mechanosensory hair cells!

#fishsci #evo-devo #CRISPR

25.09.2025 10:38 β€” πŸ‘ 4    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
A headline reading:  "You can hold on to your butts thanks to DNA that evolved in fish"

A headline reading: "You can hold on to your butts thanks to DNA that evolved in fish"

The paper: the genetic program that enables digit formation in limbs is derived from the system that drives cformation of the cloaca.

Me, the headline writer:

18.09.2025 16:45 β€” πŸ‘ 448    πŸ” 120    πŸ’¬ 21    πŸ“Œ 7