Carolina Parada Borja

Dual Bmp-negative feedback loops modulate function of both AER and ZPA to buffer and constrain postaxial digit number | PNAS Several lines of evidence indicate that posterior (postaxial) digit number in tetrapod vertebrates is constrained to the pentadactyl state by inter...

transport yourself to the late 90s with this really cool paper on digit number regulation by Shh and BMP, ZPA and AER. www.pnas.org/doi/10.1073/...

We are hiring ! Interested in understanding how neuronal cell diversity arises? Come and join us @upf.edu for a #PhD #FPI fellowship

The evolution of hominin bipedalism in two steps - Nature The human pelvis exhibits distinct spatiotemporal ossification patterns and an ilium cartilage growth plate that is shifted perpendicularly compared with those of other mammals and non-human primates—...

1) I am delighted to present this terrific tour de force research conducted by my post-doc Dr. Gayani Senevirathne @gayani.bsky.social and published today in Nature -
www.nature.com/articles/s41...

How can cells self-organize rapidly into complex patterns during development?

Let’s explore a powerful and underappreciated mechanism: Directed Cell Migration (DCM).

Preprint @biorxivpreprint.bsky.social : doi.org/10.1101/2025...

👇Thread 🧵(1/11)

A pivotal role for Wnt antagonists in constraining Wnt activity to promote digit joint specification. https://www.biorxiv.org/content/10.1101/2025.07.17.665381v1

Many thanks to Ruoheng Li and @prelights.bsky.social for featuring our preprint!

Schematics depicting the dorsal and ventral sides of fins and limbs

We take for granted that our hands have two sides and can articulate in an endless number of ways. But what about a fish’s fin? Can a fish know something “like the back of its fin,” or have its future told with a fin palm reading? Check out this bluetorial to find out 👇🧪🧬🐟 doi.org/10.1101/2025...

Muchas felicidades, Cristina! 👏

🚨 Early bird deadline: July 15th!

Human fingertip regeneration follows clinical phases with distinct proteomic signatures – a Comprehensive MS/MS analysis Distal injuries in human fingertips can regenerate almost fully, yet the process of human fingertip regeneration has hardly been characterized on a cellular and molecular level. A silicone finger cap,...

Preprint alert from our lab!
Human fingertip regeneration is not reserved for infants. Adults can regenerate with little to no scarring! We analysed wound fluids of patients during the course of regeneration and found that...

www.medrxiv.org/content/10.1...

Changes in Evolutionary Developmental Control Points in the Amniote Limb May Explain Hyperphalangy academic.oup.com/mbe/article/...

F-BIAS: Towards a distributed national core facility for bioimage analysis † Author summary We describe our experience in creating a nationwide core facility offering services in bioimage analysis. This virtual facility federates existing resources scattered across the territo...

Our paper describing the creation of a nationwide core facility for bioimage analysis if out in @plos Computational Biology!
🎉✌️

journals.plos.org/ploscompbiol...

So happy about this paper and how the work turned out.
A small thread 👇

#bioimageanalysis #corefacility

Do you want to join us to work in neurodevelopmental biology? Please apply 👇 #SEBD

The origin of vertebrate teeth and evolution of sensory exoskeletons - Nature Re-examination of the presumed Cambrian fossil fish Anatolepis reveals previous misidentification of aglaspidid sensory structures as dentine, a vertebrate sensory tissue, showing it to be an arthropod, and shifting the origin of vertebrate hard tissues to the Middle Ordovician.

Nature research paper: The origin of vertebrate teeth and evolution of sensory exoskeletons

https://go.nature.com/4jduyKk

Many cells during development are exposed to caspase activation and yet survive. Why some die and not others ? We found out that the memory of previous caspase activation bias significantly later death comitment and bias death distribution and single cell decision
www.biorxiv.org/content/10.1...

Delighted that our work on positional memory is now published. We asked how axolotl cells 'know' which part of the limb to regenerate after injury.
www.nature.com/articles/s41...
A joy to work with super team Sarah Plattner, Yuka Sugiura, Francisco Falcon and Elly Tanaka.
🧵1/14

Live imaging and functional characterization of the avian hypoblast redefine the mechanisms of primitive streak induction In birds and mammals, the formation of the primitive streak, the hallmark of the primary axis and site of gastrulation, is thought to occur when an anterior displacement of the hypoblast (visceral end...

🚨New preprint
Glad to share my postdoc work on the role of the hypoblast in primitive streak induction! Discover how live imaging observations led us to revisit the molecular mechanisms governing embryonic axis induction
Thanks to @jeromegros.bsky.social and all co-authors!
doi.org/10.1101/2025...

Direct measurements of active forces and material properties unveil the active mechanics of early embryogenesis Despite progress in probing tissue mechanics, direct long-term measurements in live embryonic epithelia are lacking. This limits our understanding of amniote embryonic morphogenesis, which takes place...

🚨📣 New preprint alert!
Excited to share my new postdoc work on direct force and mechanical properties measurements in live embryos!
A great team effort with A. Chamolly (theory), under the supervision of F. Corson and @jeromegros.bsky.social
📄 www.biorxiv.org/content/10.1...
#devbio #mechanics

Expansion microscopy micrograph of the choanoflagellate Choanoeca flexa, vaguely evocative of a cactus. Red = tubulin, green = actin, blue = DNA

Same with yellow = lipids (BODIPY)

A dream come true: the first expansion microscopy images of C. flexa 🤩 Generated by Mylan & Uzuki who learned from the best (@hiralshah.bsky.social @gautamdey.bsky.social @dudinlab.bsky.social). We will learn so much from these!

Beautiful!

Do you like Dev Bio ? Yes !
Do you like French Dev Bio ? Yes !!
The SFBD (French Society for Dev Bio) is here to promote research in embryology and post-embryonic development, growth, differentiation, regeneration, teratology and genetics on all multicellular organisms using any kind of methology

Postdoctoral research position in Institut Pasteur

🚨 JOB OFFER in our lab at Institut Pasteur 🚨
We are looking for a postdoc! Please repost 🙏

Check out these feather buds on the chicken embryo's wing! Our latest study @plosbiology.org reveals that temporary inhibition of sonic hedgehog signalling transforms feathers into simple, protofeather-like structures—similar to those of their dinosaur ancestors🔬🦖🧪

journals.plos.org/plosbiology/...

Thrilled to announce that I am looking for a Research Technician/Assistant to join my lab @imbavienna.bsky.social. Please consider applying if you’re enthusiastic about #devbio #stemcells #teamwork and excited to help shaping a new lab!

Thankful for any retweet! 🫶

imba.onlyfy.jobs/job/l6u2m980

PhD opportunity in Paris! 🇫🇷

Passionate about regeneration?
Join our lab to explore the role of Redox signaling in embryonic-like reprogramming during gut regeneration using zebrafish, mouse organoids & live imaging!

Interested? Message me! #PhD #Zebrafish #Regeneration #Gut

Grosse mobilisation des Pasteurien-nes avant le départ pour la marche de #StandUpForScienceFrance
En solidarité avec nos collègues aux US (et sur toute le planète) qui voient leur liberté académique entravée ✊
@pasteur.fr @sufs-paris-rp.bsky.social
#StandUpForScience

Science, research & public health face unprecedented attacks in the U.S.

We stand with our American colleagues & support the Stand Up for Science call.

Join the global march tomorrow, incl. in Paris! 🧪✊

📍 March 7, 13:30 – Place Jussieu
🔗 More info: standupforscience.fr

#StandUpForScience

Top: Immunostaining reveals aggrecan (yellow) at the articular surfaces in the pelvic joint of an embryonic little skate (stage 33). The nucleus is stained using DAPI and is shown in red. Bottom: Phylogenetic tree adapted from Donoghue and Keating, annotated to show that synovial joints exist in extant jawed vertebrates (gnathostomes), but the study’s results do not support their existence in cyclostomes. The presence of reciprocally shaped and cavitated joints in the dermal skeleton of antiarchs suggests that joints that function by relative sliding (similar to synovial joints) first originated in stem gnathostomes.

When did synovial joints evolve? @neelimasharma.bsky.social @neilshubin.bsky.social &co reveal that stable, mobile & lubricated joints were present in the common ancestor of jawed fishes but lacking in jawless ones 🧪 @plosbiology.org plos.io/3CTC8La

Announcing this upcoming conference:

GASTRULATION RELOADED:
Developing, engineering, and evolving the body plan

Join us as we explore the latest research on gastrulation and axis formation/elongation, featuring common, exotic, and synthetic embryos!

📅 14–17 October 2025
📍 Paris, France

My PhD paper is now online!
doi.org/10.1016/j.cu...
Big thanks to @mongeralab.bsky.social, K. Guevorkian and O. Pourquié!
See the tweetorial below ⤵️