Laura Hulea

📣 Save the date and join us in Calgary next year from November 2-4 for the #CCRC2025! Subscribe for exciting updates: ccra-acrc.ca/conference/.

We hope to see you there!

Haem biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue - Nature Metabolism Inhibition of haem synthesis is shown to lead to the accumulation of branched-chain amino acids in the brown adipose tissue of mice, which reduces UCP1 levels and impairs thermogenesis.

RESEARCH | ‪@dylanduerre.bsky.social @andreagalmozzi.bsky.social‬ et al. - ‪@uwmadison.bsky.social‬

Inhibition of haem synthesis is shown to lead to the accumulation of branched-chain amino acids in the brown adipose tissue of mice, which impairs #thermogenesis 🐁🌡️

www.nature.com/articles/s42...

Free access until 12 July 2025 👉 authors.elsevier.com/a/1l8XU3QxxS...

Huge thanks to @cp-trendscellbio.bsky.social's editorial team and great reviewers for the helpful feedback, and to @fmercier.bsky.social for a beautiful, long-standing collaboration! #cancerbiology #RNAtranslation #AML #SciCollab

Excited to share our latest review in
@cp-trendscellbio.bsky.social
🧬 We unpack how dysregulated mRNA translation rewires metabolism & drives therapy resistance in AML—and why eIF4A inhibitors look so promising. doi.org/10.1016/j.tc...
#cancerbiology #translation #AML #mTOR

Excited to share our latest review in @cp-trendscellbio.bsky.social 🧬 We unpack how dysregulated mRNA translation rewires metabolism & drives therapy resistance in AML—and why eIF4A inhibitors look so promising. doi.org/10.1016/j.tc...
#cancerbiology #translation #AML #mTOR

Translational control of leukemic metabolism and disease progression Acute myeloid leukemia (AML) is an aggressive hematological cancer with a 70% five-year mortality rate. Relapse occurs in approximately half of adults treated with intensive chemotherapy, while responses to targeted therapies are short-lasting. Frequent mutations in signaling pathways, such as FLT3 tyrosine kinase and RAS, lead to dysregulated mammalian target of rapamycin complex 1 (mTORC1)and mitogen-activated protein kinase (MAPK) signaling, increased protein synthesis, enhanced mitochondrial fitness, and metabolic adaptations that drive leukemic cell proliferation and survival. Here, emerging evidence supporting the unique role of eukaryotic initiation factor 4F as a key driver of the expression of proteins regulating leukemic cell metabolism and survival and the potential therapeutic benefit of targeting this pathway pharmacologically in AML are discussed.

Translational control of leukemic metabolism and disease progression

New protocol drop! 🧪 Check out our polysome profiling in primary differentiating murine adipocytes 🐭🧫 — a step-by-step guide to studying translational control during adipogenesis. 👉 star-protocols.cell.com/protocols/4182
@laurahulea.bsky.social @claudiovillanueva.bsky.social

Sad to hear that Dr. Henry Friesen, who had a transformative influence on health research in Canada, has died at age 90. He discovered the hormone prolactin and founded the Canadian Institutes of Health Research, among his many accomplishments. www.cdnmedhall.ca/laureates/he...

I urge folks to sign this letter and share it with their university colleagues to get critical mass.

Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics - Nature Metabolism Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pat...

www.nature.com/articles/s42...

Metabolites are not genes. repeat, please!

National Letter Open Letter from Canadian Researchers to the Federal party leaders Click here to sign this letter See who has signed - version française se trouve à page 3 - Dear Party Leaders We, the undersigne...

Dear Canadian researchers, faculty, RAs, PDFs and grad students, this letter is for the federal party leaders asking them to defend and expand Canadian research sovereignty with a historic investment in science, please sign and share
docs.google.com/document/d/1...

🚨New paper!🚨

A comprehensive take on the origins and evolution of translation factors & how these essential players evolved across the tree of life. 🌍🧬

Led by Evrim Fer @uwmadisonmdtp.bsky.social grad student! 👏

Free access: www.sciencedirect.com/science/arti... @cp-trendsgenetics.bsky.social

The Futile Creatine Cycle powers UCP1-independent thermogenesis in classical BAT Nature Communications - Thermogenesis by brown adipose tissue has long been thought to be solely controlled by uncoupling protein 1 (UCP1). Here, the authors show that energy expenditure in brown...

Today in @naturecomms.bsky.social we show the #FutileCreatineCycle plays a key role in #thermogenesis, independent of UCP1. We also challenge the belief that brown adipocytes lack enough ATP synthase for thermogenesis. Congrats to Jakub Bunk! @mcgillgci.bsky.social

Full paper: rdcu.be/egoV7

🧬 L'avenir de la médecine génomique et ses implications dans les thérapies #ARN

Rejoignez-nous pour un colloque organisé par @d2rmcgill.bsky.social et @AReNA lors du 92e Congrès de l’
@acfas.ca !

📅5 mai 2025 🕐12h45

💡 En savoir plus : mcgill.ca/dna-to-rna/f...

#ACFAS8

The Terry Fox Research Institute Marathon of Hope Cancer Centres Network: A pan-Canadian precision oncology initiative The Marathon of Hope Cancer Centres Network (MOHCCN), led by the Terry Fox Research Institute and the Terry Fox Foundation, unites researchers, clinic…

Terry Fox Marathon of Hope Cancer Centres Network has just published it's marker paper, led by Drs. Veronique LeBlanc and Marco Marra. Following link gives free access/download for the next 50 days (will then be fully OA after a year). Can DM me for a PDF 🤫 www.sciencedirect.com/science/arti...

🚨We're hiring another tenure-track at McGill University: focus on brain-body science! 👇

mcgill.wd3.myworkdayjobs.com/en-US/mcgill...

Speaker Spotlight: Dr. Mitch Lazar @upenn.bsky.social
Join us @ #AdiposeBiology Conference in Montreal🇨🇦, Aug 19-20, 2025, to hear from Mitch about #nuclearreceptor & circadian metabolism. Don’t miss his talk!

🔗 Register now – adiposebiology.com

#ABC2025 #Metabolism #ObesityResearch @mcgill.ca

Moonlighting functions of glucose metabolic enzymes and metabolites in cancer - Nature Reviews Cancer Glucose metabolic enzymes and their metabolites provide cells with energy and building blocks for the synthesis of macromolecules. However, it has become clear that they also have non-canonical functi...

www.nature.com/articles/s41...

Canada Excellence Research Chairs (CERC) - Montréal, Quebec (CA) job with University of Montreal (UdeM) | 12838461 Canada Excellence Research Chairs (CERC)

Fantastic opportunity if you are interested in moving your lab to Montreal, Canada! Through this program, Chairholders will be awarded up to $1 million per year for a period of 8 years.

Contact me if you are interested.

www.nature.com/naturecareer...

Great chance for Canadian researchers to attend a great scientific meeting in Canada!

2025 Midwest Metabolism Meeting Join us for 2025 Midwest Metabolism Meeting at Van Andel Institute Stay informed about exciting upcoming events and activities.

Registration is live for the 1st ever Midwest Metabolism & TRiMAD dual meeting, hosted jointly by VAI + U of M in Ann Arbor, MI November 10-11, 2025! We have some exciting speakers but most will come from abstracts so submit your best #mitochondria & #metabolism research! www.vai.org/event/2025-m...

Glad to announce the 1st Basic & Clinical Oncology (BCO) conference on May 7 at the IRCM/Montreal as a partnership between 9 institutes/networks across Quebec! Clinical and basic cancer research abstracts are welcome (deadline April 6). More details: www.ircm.qc.ca/en/events/de...
#Montreal #Quebec

Oxidation of retromer complex controls mitochondrial translation - Nature Systematic base-editing and computational screens identify specific cysteine residues on VPS35 in the retromer complex as key sensors that decrease mitochondrial translation in response to reactive ox...

I’m excited to share the latest work from our lab, led by a group of three amazing scientists: Junbing Zhang, Yousuf Ali and Harrison Chong, who describe @nature the discovery of a ROS sensor, VPS35, which links cytosolic H2O2 levels to regulation of mitochondrial translation and

Plasticity of the mammalian integrated stress response - Nature A study describes the split integrated stress response, a cellular stress response mechanism characterized by reduced eIF2B activity without eIF2α phosphorylation, which activates the eIF4E–ATF4–PCK2 ...

www.nature.com/articles/s41...

Plasticity of the mammalian integrated stress response

'You never catch up.' Why the gender pay gap is so much worse for caregivers The gender pay gap widened slightly from 2022 to 2023. The gap is worse for women of color and widens as women age because of their caregiving duties.

The gender pay gap only rises with age:
15-24: 15%
25-34: 20%
35-44: 25%
45-54: 31%
55-64: 34%
65+: 37%
And there's a motherhood penalty: The pay gap for women w/o kids is 12%; with kids=25%.
@maddiemitch.bsky.social
www.usatoday.com/story/money/...

Proud to share the work of my forst ever PhD student and first author of this paper @dylanduerre.bsky.social!! Here, he summarizes it perfectly! #brownfat #metabolism #BCAA #heme @uwmadison.bsky.social @uofutahcihd.bsky.social

ISEH mini-symposium is taking place tomorrow! Don’t forget to register and join us for some great science!!! 🧪 🧫 🧬 🩸 🐁

Linocut portrait of biochemist and medical researcher Maud Menten (1879-1960) with the Michalis-Menten equation in blue and a histology image in pinks and purples in the background.

Happy birthday to Canadian medical researcher & #biochemist Maud Menten (1879-1960). 🧪🐡👩🏼‍🔬 #histscj Not only was she an author of Michaelis-Menten equation for enzyme kinetics, she invented the azo-dye coupling for alkaline phosphatase, 1st example of enzyme histochemistry, still used in imaging of 🧵

Assistant Professor - Neuroscience Job Family: Academic Leadership and Faculty Union affiliation: APUO Faculty/Department: School of Psychology_FT Campus: Main Campus Date Posted: February 14, 2025 Applications must be received BEFORE:...

New position- Assistant Professor in Neuroscience at U. Ottawa!

uottawa.wd3.myworkdayjobs.com/en-US/uOttaw...

Assistant Professor (Tenure-Track) Academic Job Category Faculty Bargaining Job Title Assistant Professor (Tenure-Track) Department Department of Medical Genetics | Faculty of Medicine | Provost and VP Academic (Jehannine Austin) Posti...

Come work with us in Vancouver! UBC’s Department of Medical Genetics, in collaboration with The Life Sciences Institute, seeks an Assistant Professor working in chromatin regulation or genetic regulatory mechanisms.

ubc.wd10.myworkdayjobs.com/en-US/ubcfac...